Clinical implications in the shift of syndecan-1 expression from the cell membrane to the cytoplasm in bladder cancer

• Published in: BMC cancer Vol. 14; no. 1; p. 86
• Main Authors: Miyake, Makito, Lawton, Adrienne, Dai, Yunfeng, Chang, Myron, Mengual, Lourdes, Alcaraz, Antonio, Goodison, Steve, Rosser, Charles J
• Format: Journal Article
• Language: English
• Published: England BioMed Central 13.02.2014; BioMed Central Ltd
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Assaigs clínics; Biochemical markers; Biomarkers; Biomedical research; Bladder cancer; Cell Membrane - metabolism; Cell Membrane - pathology; Clinical trials; Cohort Studies; Cytoplasm; Cytoplasm - metabolism; Cytoplasm - pathology; Càncer de bufeta; Female; Gene expression; Gene Expression Regulation, Neoplastic; Heparan sulfate; Hospitals; Humans; Male; Marcadors bioquímics; Medical research; Middle Aged; Proteins; Review boards; Single-Blind Method; Studies; Syndecan-1 - biosynthesis; Syndecan-1 - genetics; Tumors; Urinary Bladder Neoplasms - diagnosis; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - metabolism; Urogenital system; Young Adult

To determine the diagnostic and prognostic capability of urinary and tumoral syndecan-1 (SDC-1) levels in patients with cancer of the urinary bladder. SDC-1 levels were quantitated by enzyme-linked immunosorbent assay (ELISA) in 308 subjects (102 cancer subjects and 206 non-cancer subjects) to asses...