The different molecular forms of urine neutrophil gelatinase-associated lipocalin present in dogs with urinary diseases

• Published in: BMC veterinary research Vol. 10; no. 1; p. 202
• Main Authors: Hsu, Wei-Li, Chiou, Hsiao-Chi, Tung, Kwong-chung, Belot, Guillaume, Virilli, Anais, Wong, Min-Liang, Lin, Fong-Yuan, Lee, Ya-Jane
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.08.2014; BioMed Central
• Subjects: Acute-Phase Proteins - urine; Analysis; Animals; biomarkers; cystitis; Diagnosis; Dog Diseases - metabolism; Dog Diseases - urine; Dogs; Enzyme-Linked Immunosorbent Assay - veterinary; Family medical history; Female; Gene Expression Regulation - physiology; Heart surgery; Kidney diseases; Lipocalins - urine; Medical treatment; Mice; neutrophils; prediction; Protein Isoforms - genetics; Protein Isoforms - metabolism; Proto-Oncogene Proteins - urine; Teaching hospitals; Urine; Urogenital system; Urologic Diseases - metabolism; Urologic Diseases - veterinary; Variance analysis; Veterinary colleges; Veterinary medicine; Western blotting

Neutrophil gelatinase-associated lipocalin (NGAL) is a useful biomarker for the early prediction of renal diseases. NGAL may exist as monomer, dimer and/or NGAL/MMP-9 complex forms in humans. In this study, the existence of various forms of NGAL in urine (uNGAL) was determined and whether these form...