Functional magnetic resonance imaging (fMRI) changes and saliva production associated with acupuncture at LI-2 acupuncture point: a randomized controlled study
Clinical studies suggest that acupuncture can stimulate saliva production and reduce xerostomia (dry mouth). We were interested in exploring the neuronal substrates involved in such responses. In a randomized, sham acupuncture controlled, subject blinded trial, twenty healthy volunteers received tru...
Saved in:
Published in | BMC complementary and alternative medicine Vol. 8; no. 1; p. 37 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
BioMed Central Ltd
07.07.2008
BioMed Central BMC |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Clinical studies suggest that acupuncture can stimulate saliva production and reduce xerostomia (dry mouth). We were interested in exploring the neuronal substrates involved in such responses.
In a randomized, sham acupuncture controlled, subject blinded trial, twenty healthy volunteers received true and sham acupuncture in random order. Cortical regions that were activated or deactivated during the interventions were evaluated by functional magnetic resonance imaging (fMRI). Saliva production was also measured.
Unilateral manual acupuncture stimulation at LI-2, a point commonly used in clinical practice to treat xerostomia, was associated with bilateral activation of the insula and adjacent operculum. Sham acupuncture at an adjacent site induced neither activation nor deactivation. True acupuncture induced more saliva production than sham acupuncture.
Acupuncture at LI-2 was associated with neuronal activations absent during sham acupuncture stimulation. Neuroimaging signal changes appear correlated to saliva production. |
---|---|
AbstractList | Background Clinical studies suggest that acupuncture can stimulate saliva production and reduce xerostomia (dry mouth). We were interested in exploring the neuronal substrates involved in such responses. Methods In a randomized, sham acupuncture controlled, subject blinded trial, twenty healthy volunteers received true and sham acupuncture in random order. Cortical regions that were activated or deactivated during the interventions were evaluated by functional magnetic resonance imaging (fMRI). Saliva production was also measured. Results Unilateral manual acupuncture stimulation at LI-2, a point commonly used in clinical practice to treat xerostomia, was associated with bilateral activation of the insula and adjacent operculum. Sham acupuncture at an adjacent site induced neither activation nor deactivation. True acupuncture induced more saliva production than sham acupuncture. Conclusion Acupuncture at LI-2 was associated with neuronal activations absent during sham acupuncture stimulation. Neuroimaging signal changes appear correlated to saliva production. Clinical studies suggest that acupuncture can stimulate saliva production and reduce xerostomia (dry mouth). We were interested in exploring the neuronal substrates involved in such responses. In a randomized, sham acupuncture controlled, subject blinded trial, twenty healthy volunteers received true and sham acupuncture in random order. Cortical regions that were activated or deactivated during the interventions were evaluated by functional magnetic resonance imaging (fMRI). Saliva production was also measured. Unilateral manual acupuncture stimulation at LI-2, a point commonly used in clinical practice to treat xerostomia, was associated with bilateral activation of the insula and adjacent operculum. Sham acupuncture at an adjacent site induced neither activation nor deactivation. True acupuncture induced more saliva production than sham acupuncture. Acupuncture at LI-2 was associated with neuronal activations absent during sham acupuncture stimulation. Neuroimaging signal changes appear correlated to saliva production. Abstract Background Clinical studies suggest that acupuncture can stimulate saliva production and reduce xerostomia (dry mouth). We were interested in exploring the neuronal substrates involved in such responses. Methods In a randomized, sham acupuncture controlled, subject blinded trial, twenty healthy volunteers received true and sham acupuncture in random order. Cortical regions that were activated or deactivated during the interventions were evaluated by functional magnetic resonance imaging (fMRI). Saliva production was also measured. Results Unilateral manual acupuncture stimulation at LI-2, a point commonly used in clinical practice to treat xerostomia, was associated with bilateral activation of the insula and adjacent operculum. Sham acupuncture at an adjacent site induced neither activation nor deactivation. True acupuncture induced more saliva production than sham acupuncture. Conclusion Acupuncture at LI-2 was associated with neuronal activations absent during sham acupuncture stimulation. Neuroimaging signal changes appear correlated to saliva production. BACKGROUNDClinical studies suggest that acupuncture can stimulate saliva production and reduce xerostomia (dry mouth). We were interested in exploring the neuronal substrates involved in such responses. METHODSIn a randomized, sham acupuncture controlled, subject blinded trial, twenty healthy volunteers received true and sham acupuncture in random order. Cortical regions that were activated or deactivated during the interventions were evaluated by functional magnetic resonance imaging (fMRI). Saliva production was also measured. RESULTSUnilateral manual acupuncture stimulation at LI-2, a point commonly used in clinical practice to treat xerostomia, was associated with bilateral activation of the insula and adjacent operculum. Sham acupuncture at an adjacent site induced neither activation nor deactivation. True acupuncture induced more saliva production than sham acupuncture. CONCLUSIONAcupuncture at LI-2 was associated with neuronal activations absent during sham acupuncture stimulation. Neuroimaging signal changes appear correlated to saliva production. |
ArticleNumber | 37 |
Audience | Academic |
Author | Deng, Gary Cassileth, Barrie R Hou, Bob L Holodny, Andrei I |
AuthorAffiliation | 2 Functional MRI Laboratory, Memorial Sloan-Kettering Cancer Center, 1429 First Avenue, New York, NY 10021, USA 1 Integrative Medicine Service, Memorial Sloan-Kettering Cancer Center, 1429 First Avenue, New York, NY 10021, USA |
AuthorAffiliation_xml | – name: 1 Integrative Medicine Service, Memorial Sloan-Kettering Cancer Center, 1429 First Avenue, New York, NY 10021, USA – name: 2 Functional MRI Laboratory, Memorial Sloan-Kettering Cancer Center, 1429 First Avenue, New York, NY 10021, USA |
Author_xml | – sequence: 1 givenname: Gary surname: Deng fullname: Deng, Gary email: dengg@mskcc.org organization: Integrative Medicine Service, Memorial Sloan-Kettering Cancer Center, 1429 First Avenue, New York, NY 10021, USA. dengg@mskcc.org – sequence: 2 givenname: Bob L surname: Hou fullname: Hou, Bob L – sequence: 3 givenname: Andrei I surname: Holodny fullname: Holodny, Andrei I – sequence: 4 givenname: Barrie R surname: Cassileth fullname: Cassileth, Barrie R |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18606019$$D View this record in MEDLINE/PubMed |
BookMark | eNqFk11rFDEUhgep2A-99VICQtGLqZNkMsn0QliK1YWKIHodMsnJbMpMsk5mKvXP-FfNdJe6i5WSi4T3vOchOefkODvwwUOWvcTFGcaieodLTvJKCJKLnPIn2dG9cLBzPsyOY7wuCswFLp9lhymzqApcH2W_LyevRxe86lCvWg-j02iAmASvAbmkOd-iN_bz1-VbpFfKtxCR8gZF1bkbhdZDMNMdAakYg3ZqBIN-unGFlJ7WM30aAKkRXS1zsqetg_PjOVJoSLzQu18pUQc_DqHr0jGOk7l9nj21qovwYrufZN8vP3y7-JRfffm4vFhc5Q0TnOdMW0s0tU2BaaNYaRvODYWywSXUrCGEQ00wYcYIU1eUgkphYYQSwJoCBD3JlhuuCeparof08OFWBuXknRCGVqoh1aYDWRtOysoSboqmVJTUVQ1QcltSaxUhLLHeb1jrqenBaEhPUt0edD_i3Uq24UaSkpeMkwRYbACNC_8B7Ed06OXcbDk3WwpJeWKcbi8xhB8TxFH2LmroOuUhTFFWNcWlqNijRoILxitcPWrENWWsxjPx9cbYqlQu521Il9SzWS6wwCwNHp8rfvaAKy0DvUtjANYlfS_hdCdhBaobVzF00zx78UGyHkKMA9j7yuFCzr_m31q92m3YX_v2m9A_5qcWIg |
CitedBy_id | crossref_primary_10_1177_201010581202100108 crossref_primary_10_1089_acu_2015_1104 crossref_primary_10_1002_cncr_27382 crossref_primary_10_1016_j_jams_2015_04_002 crossref_primary_10_2174_1573405615666190220113111 crossref_primary_10_1007_s11655_013_1436_4 crossref_primary_10_1111_j_2042_7166_2009_tb01891_x crossref_primary_10_1177_15347354221101630 crossref_primary_10_1155_2015_585493 crossref_primary_10_1002_ar_24784 crossref_primary_10_1111_j_2042_7166_2010_01048_x crossref_primary_10_1007_s10103_014_1590_8 crossref_primary_10_1055_a_1263_2976 crossref_primary_10_1007_s00761_019_0521_5 crossref_primary_10_1093_jncimonographs_lgz016 crossref_primary_10_1155_2016_3685785 crossref_primary_10_1634_theoncologist_2009_S504 crossref_primary_10_3390_ijms241411654 crossref_primary_10_1007_s11839_011_0325_3 crossref_primary_10_1016_j_ctrv_2017_07_003 crossref_primary_10_1200_JCO_2012_43_5818 crossref_primary_10_1002_nbm_1335 crossref_primary_10_1016_j_ijrobp_2010_06_052 crossref_primary_10_1001_jamanetworkopen_2024_10421 crossref_primary_10_1016_j_oooo_2013_02_017 crossref_primary_10_1007_s11864_010_0131_3 crossref_primary_10_1136_aim_2010_002733 crossref_primary_10_1186_1749_8546_4_1 crossref_primary_10_1016_j_acu_2022_100204 crossref_primary_10_1016_j_cct_2012_02_017 crossref_primary_10_1093_jncimonographs_lgx005 crossref_primary_10_1093_annonc_mds515 crossref_primary_10_1136_aim_2009_000935 crossref_primary_10_1002_hed_27297 crossref_primary_10_1586_era_09_100 crossref_primary_10_1002_cncr_26550 crossref_primary_10_1016_j_jep_2011_06_004 crossref_primary_10_1055_a_1558_5820 crossref_primary_10_3389_fnagi_2018_00206 crossref_primary_10_1177_1534735410378856 crossref_primary_10_1007_s00405_021_07002_1 crossref_primary_10_1007_s00060_019_5894_y crossref_primary_10_1007_s11655_017_2924_8 crossref_primary_10_1016_j_jpain_2012_11_011 crossref_primary_10_1177_1534735420980825 crossref_primary_10_3389_fnhum_2021_694919 crossref_primary_10_1016_j_autneu_2015_03_006 crossref_primary_10_1200_JCO_2009_23_5150 crossref_primary_10_1136_bmjopen_2019_031892 crossref_primary_10_1016_j_eujim_2011_02_006 crossref_primary_10_1016_j_jtcme_2017_04_004 crossref_primary_10_1089_acm_2016_0283 crossref_primary_10_1177_1534735412451321 crossref_primary_10_1088_1742_6596_884_1_012127 crossref_primary_10_1371_journal_pone_0032960 crossref_primary_10_4103_2225_4110_119733 crossref_primary_10_1016_j_jams_2015_03_005 crossref_primary_10_1200_JCO_2009_26_9860 |
Cites_doi | 10.1093/chemse/26.4.371 10.1007/s00701-004-0311-7 10.1111/j.1365-2842.1997.tb00314.x 10.1111/j.1601-0825.2000.tb00316.x 10.1523/JNEUROSCI.3556-05.2006 10.1191/0269216302pm540oa 10.1002/cne.902440208 10.1002/mrm.1910300204 10.1016/j.neuroimage.2005.01.016 10.1093/chemse/bji052 10.7326/0003-4819-141-12-200412210-00006 10.1016/j.ejpain.2004.11.001 10.1200/JCO.2003.09.011 10.7326/0003-4819-136-5-200203050-00010 10.1016/j.neuroimage.2006.10.019 10.1006/nimg.1997.0278 10.1148/radiology.212.1.r99jl04133 10.1016/S0360-3016(03)00572-8 10.1002/cncr.10348 10.1002/(SICI)1097-0193(2000)9:1<13::AID-HBM2>3.0.CO;2-F 10.1016/S0006-8993(03)02983-4 10.1016/S0304-3959(00)00293-1 10.1016/S0140-6736(97)10471-8 10.1373/49.4.658 10.1093/ecam/neh110 10.1089/107555302760253603 10.1126/science.1093065 10.1016/j.neuroimage.2005.04.037 10.1136/bmj.38726.603310.55 10.1006/cbmr.1996.0014 10.1016/S0360-3016(00)01530-3 10.1038/35084005 |
ContentType | Journal Article |
Copyright | COPYRIGHT 2008 BioMed Central Ltd. Copyright © 2008 Deng et al; licensee BioMed Central Ltd. 2008 Deng et al; licensee BioMed Central Ltd. |
Copyright_xml | – notice: COPYRIGHT 2008 BioMed Central Ltd. – notice: Copyright © 2008 Deng et al; licensee BioMed Central Ltd. 2008 Deng et al; licensee BioMed Central Ltd. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7TK 7X8 5PM DOA |
DOI | 10.1186/1472-6882-8-37 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Neurosciences Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Neurosciences Abstracts MEDLINE - Academic |
DatabaseTitleList | Neurosciences Abstracts Neurosciences Abstracts MEDLINE MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1472-6882 |
EndPage | 37 |
ExternalDocumentID | oai_doaj_org_article_9d7246f27d0b4a32969ee47f43ffa225 oai_biomedcentral_com_1472_6882_8_37 A181501978 10_1186_1472_6882_8_37 18606019 |
Genre | Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article |
GeographicLocations | United States |
GeographicLocations_xml | – name: United States |
GroupedDBID | --- -A0 0R~ 23N 2VQ 2WC 4.4 53G 5VS 6J9 6PF A8Z AAFWJ AAWTL ACGFO ACGFS ACMJI ACPRK ADBBV ADINQ ADRAZ AENEX AFGXO AFPKN AFRAH AHBYD AHMBA AHSBF AHYZX ALMA_UNASSIGNED_HOLDINGS AMKLP AOIJS BAWUL BCNDV BFQNJ BMC C1A C24 CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD EMB EMOBN ESTFP F5P GROUPED_DOAJ GX1 HYE IAO IHR IHW INH INR IPNFZ ITC KQ8 M48 M~E NPM O5R O5S OK1 P2P RBZ RIG RNS ROL RPM RSV SMD SV3 TR2 UNMZH W2D WOQ WOW XSB AAHBH AAYXX ALIPV CITATION H13 PGMZT 7TK 7X8 5PM |
ID | FETCH-LOGICAL-b5877-5cff2c3fb013ba54fb77d3e4b14e95b227e92125dd8d9633ea7d38d8a8e5b0e83 |
IEDL.DBID | RPM |
ISSN | 1472-6882 |
IngestDate | Thu Jul 04 21:09:10 EDT 2024 Tue Sep 17 21:24:52 EDT 2024 Tue Apr 16 22:46:11 EDT 2024 Fri Aug 16 07:57:10 EDT 2024 Fri Aug 16 22:40:49 EDT 2024 Fri Aug 16 01:36:48 EDT 2024 Fri Feb 23 00:21:46 EST 2024 Tue Feb 13 05:06:52 EST 2024 Tue Aug 20 22:14:18 EDT 2024 Thu Sep 12 18:17:54 EDT 2024 Thu May 23 23:13:20 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Issue | 1 |
Language | English |
License | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-b5877-5cff2c3fb013ba54fb77d3e4b14e95b227e92125dd8d9633ea7d38d8a8e5b0e83 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-News-1 ObjectType-Feature-3 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474572/ |
PMID | 18606019 |
PQID | 19355915 |
PQPubID | 23462 |
PageCount | 1 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_9d7246f27d0b4a32969ee47f43ffa225 pubmedcentral_primary_oai_pubmedcentral_nih_gov_2474572 biomedcentral_primary_oai_biomedcentral_com_1472_6882_8_37 proquest_miscellaneous_69314865 proquest_miscellaneous_21057616 proquest_miscellaneous_19355915 gale_infotracmisc_A181501978 gale_infotracacademiconefile_A181501978 gale_healthsolutions_A181501978 crossref_primary_10_1186_1472_6882_8_37 pubmed_primary_18606019 |
PublicationCentury | 2000 |
PublicationDate | 2008-07-07 |
PublicationDateYYYYMMDD | 2008-07-07 |
PublicationDate_xml | – month: 07 year: 2008 text: 2008-07-07 day: 07 |
PublicationDecade | 2000 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | BMC complementary and alternative medicine |
PublicationTitleAlternate | BMC Complement Altern Med |
PublicationYear | 2008 |
Publisher | BioMed Central Ltd BioMed Central BMC |
Publisher_xml | – name: BioMed Central Ltd – name: BioMed Central – name: BMC |
References | 9717924 - Lancet. 1998 Aug 1;352(9125):364-5 12957259 - Int J Radiat Oncol Biol Phys. 2003 Oct 1;57(2):472-80 8812068 - Comput Biomed Res. 1996 Jun;29(3):162-73 12080615 - Rinsho Shinkeigaku. 2001 Nov;41(11):809-12 9299383 - Neuroimage. 1997 Aug;6(2):93-103 12047000 - Palliat Med. 2002 May;16(3):235-9 10405732 - Radiology. 1999 Jul;212(1):133-41 12915252 - Brain Res. 2003 Aug 29;982(2):168-78 15850733 - Neuroimage. 2005 May 1;25(4):1161-7 17157035 - Neuroimage. 2007 Feb 1;34(3):1171-81 11920486 - Cancer. 2002 Feb 15;94(4):1151-6 8366797 - Magn Reson Med. 1993 Aug;30(2):161-73 11380221 - Int J Radiat Oncol Biol Phys. 2001 Jun 1;50(2):353-7 3950095 - J Comp Neurol. 1986 Feb 8;244(2):213-28 10963911 - Pain. 2000 Sep;87(3):315-24 16506635 - Oncology (Williston Park). 2005 Dec;19(14):1827-32; discussion 1832-4, 1837-9 11369672 - Chem Senses. 2001 May;26(4):371-83 16135744 - Chem Senses. 2005 Sep;30(7):583-92 12651822 - Clin Chem. 2003 Apr;49(4):658-60 11449264 - Nature. 2001 Jul 12;412(6843):150-7 10643726 - Hum Brain Mapp. 2000;9(1):13-25 14976306 - Science. 2004 Feb 20;303(5661):1162-7 16452103 - BMJ. 2006 Feb 18;332(7538):391-7 10673783 - Oral Dis. 2000 Jan;6(1):15-24 16407533 - J Neurosci. 2006 Jan 11;26(2):381-8 11874310 - Ann Intern Med. 2002 Mar 5;136(5):374-83 16136210 - Evid Based Complement Alternat Med. 2005 Sep;2(3):315-9 12230901 - J Altern Complement Med. 2002 Aug;8(4):411-9 15611487 - Ann Intern Med. 2004 Dec 21;141(12):901-10 15979027 - Eur J Pain. 2005 Aug;9(4):463-84 14615440 - J Clin Oncol. 2003 Nov 15;21(22):4120-6 15340814 - Acta Neurochir (Wien). 2004 Sep;146(9):1021-5; discussion 1026 16046146 - Neuroimage. 2005 Sep;27(3):479-96 9131475 - J Oral Rehabil. 1997 Mar;24(3):204-8 GT Lewith (196_CR9) 2005; 2 BM Berman (196_CR4) 2004; 141 J Kong (196_CR25) 2002; 8 PA Bandettini (196_CR21) 1993; 30 D Alimi (196_CR2) 2003; 21 TJ Kaptchuk (196_CR1) 2002; 136 J Pariente (196_CR5) 2005; 25 J Kong (196_CR6) 2006; 26 AV Apkarian (196_CR27) 2005; 9 M Morita (196_CR33) 2001; 41 TD Wager (196_CR28) 2004; 303 J Kong (196_CR24) 2007; 34 WT Zhang (196_CR10) 2003; 982 PA Johnstone (196_CR16) 2002; 16 PA Johnstone (196_CR13) 2001; 50 H Ogawa (196_CR30) 2005; 30 RK Wong (196_CR14) 2003; 57 M Blom (196_CR12) 2000; 6 PA Johnstone (196_CR17) 2002; 94 UI Tuor (196_CR26) 2000; 87 TC Pritchard (196_CR31) 1986; 244 KK Hui (196_CR7) 2000; 9 KK Hui (196_CR29) 2005; 27 C de Weerth (196_CR19) 2003; 49 I Dawidson (196_CR11) 1997; 24 TJ Kaptchuk (196_CR3) 2006; 332 MS Cohen (196_CR22) 1997; 6 B Cerf-Ducastel (196_CR32) 2001; 26 MT Wu (196_CR8) 1999; 212 ST Kahn (196_CR15) 2005; 19 RW Cox (196_CR20) 1996; 29 NK Logothetis (196_CR23) 2001; 412 T Satow (196_CR34) 2004; 146 K Streitberger (196_CR18) 1998; 352 |
References_xml | – volume: 41 start-page: 809 issue: 11 year: 2001 ident: 196_CR33 publication-title: Rinsho Shinkeigaku contributor: fullname: M Morita – volume: 19 start-page: 1827 issue: 14 year: 2005 ident: 196_CR15 publication-title: Oncology (Williston Park) contributor: fullname: ST Kahn – volume: 26 start-page: 371 issue: 4 year: 2001 ident: 196_CR32 publication-title: Chem Senses doi: 10.1093/chemse/26.4.371 contributor: fullname: B Cerf-Ducastel – volume: 146 start-page: 1021 issue: 9 year: 2004 ident: 196_CR34 publication-title: Acta Neurochir (Wien) doi: 10.1007/s00701-004-0311-7 contributor: fullname: T Satow – volume: 24 start-page: 204 issue: 3 year: 1997 ident: 196_CR11 publication-title: J Oral Rehabil doi: 10.1111/j.1365-2842.1997.tb00314.x contributor: fullname: I Dawidson – volume: 6 start-page: 15 issue: 1 year: 2000 ident: 196_CR12 publication-title: Oral Dis doi: 10.1111/j.1601-0825.2000.tb00316.x contributor: fullname: M Blom – volume: 26 start-page: 381 issue: 2 year: 2006 ident: 196_CR6 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.3556-05.2006 contributor: fullname: J Kong – volume: 16 start-page: 235 issue: 3 year: 2002 ident: 196_CR16 publication-title: Palliat Med doi: 10.1191/0269216302pm540oa contributor: fullname: PA Johnstone – volume: 244 start-page: 213 issue: 2 year: 1986 ident: 196_CR31 publication-title: J Comp Neurol doi: 10.1002/cne.902440208 contributor: fullname: TC Pritchard – volume: 30 start-page: 161 issue: 2 year: 1993 ident: 196_CR21 publication-title: Magn Reson Med doi: 10.1002/mrm.1910300204 contributor: fullname: PA Bandettini – volume: 25 start-page: 1161 issue: 4 year: 2005 ident: 196_CR5 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2005.01.016 contributor: fullname: J Pariente – volume: 30 start-page: 583 issue: 7 year: 2005 ident: 196_CR30 publication-title: Chem Senses doi: 10.1093/chemse/bji052 contributor: fullname: H Ogawa – volume: 141 start-page: 901 issue: 12 year: 2004 ident: 196_CR4 publication-title: Ann Intern Med doi: 10.7326/0003-4819-141-12-200412210-00006 contributor: fullname: BM Berman – volume: 9 start-page: 463 issue: 4 year: 2005 ident: 196_CR27 publication-title: Eur J Pain doi: 10.1016/j.ejpain.2004.11.001 contributor: fullname: AV Apkarian – volume: 21 start-page: 4120 issue: 22 year: 2003 ident: 196_CR2 publication-title: J Clin Oncol doi: 10.1200/JCO.2003.09.011 contributor: fullname: D Alimi – volume: 136 start-page: 374 issue: 5 year: 2002 ident: 196_CR1 publication-title: Ann Intern Med doi: 10.7326/0003-4819-136-5-200203050-00010 contributor: fullname: TJ Kaptchuk – volume: 34 start-page: 1171 issue: 3 year: 2007 ident: 196_CR24 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2006.10.019 contributor: fullname: J Kong – volume: 6 start-page: 93 issue: 2 year: 1997 ident: 196_CR22 publication-title: Neuroimage doi: 10.1006/nimg.1997.0278 contributor: fullname: MS Cohen – volume: 212 start-page: 133 issue: 1 year: 1999 ident: 196_CR8 publication-title: Radiology doi: 10.1148/radiology.212.1.r99jl04133 contributor: fullname: MT Wu – volume: 57 start-page: 472 issue: 2 year: 2003 ident: 196_CR14 publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(03)00572-8 contributor: fullname: RK Wong – volume: 94 start-page: 1151 issue: 4 year: 2002 ident: 196_CR17 publication-title: Cancer doi: 10.1002/cncr.10348 contributor: fullname: PA Johnstone – volume: 9 start-page: 13 issue: 1 year: 2000 ident: 196_CR7 publication-title: Hum Brain Mapp doi: 10.1002/(SICI)1097-0193(2000)9:1<13::AID-HBM2>3.0.CO;2-F contributor: fullname: KK Hui – volume: 982 start-page: 168 issue: 2 year: 2003 ident: 196_CR10 publication-title: Brain Res doi: 10.1016/S0006-8993(03)02983-4 contributor: fullname: WT Zhang – volume: 87 start-page: 315 issue: 3 year: 2000 ident: 196_CR26 publication-title: Pain doi: 10.1016/S0304-3959(00)00293-1 contributor: fullname: UI Tuor – volume: 352 start-page: 364 issue: 9125 year: 1998 ident: 196_CR18 publication-title: Lancet doi: 10.1016/S0140-6736(97)10471-8 contributor: fullname: K Streitberger – volume: 49 start-page: 658 issue: 4 year: 2003 ident: 196_CR19 publication-title: Clin Chem doi: 10.1373/49.4.658 contributor: fullname: C de Weerth – volume: 2 start-page: 315 issue: 3 year: 2005 ident: 196_CR9 publication-title: Evid Based Complement Alternat Med doi: 10.1093/ecam/neh110 contributor: fullname: GT Lewith – volume: 8 start-page: 411 issue: 4 year: 2002 ident: 196_CR25 publication-title: J Altern Complement Med doi: 10.1089/107555302760253603 contributor: fullname: J Kong – volume: 303 start-page: 1162 issue: 5661 year: 2004 ident: 196_CR28 publication-title: Science doi: 10.1126/science.1093065 contributor: fullname: TD Wager – volume: 27 start-page: 479 issue: 3 year: 2005 ident: 196_CR29 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2005.04.037 contributor: fullname: KK Hui – volume: 332 start-page: 391 issue: 7538 year: 2006 ident: 196_CR3 publication-title: Bmj doi: 10.1136/bmj.38726.603310.55 contributor: fullname: TJ Kaptchuk – volume: 29 start-page: 162 issue: 3 year: 1996 ident: 196_CR20 publication-title: Comput Biomed Res doi: 10.1006/cbmr.1996.0014 contributor: fullname: RW Cox – volume: 50 start-page: 353 issue: 2 year: 2001 ident: 196_CR13 publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(00)01530-3 contributor: fullname: PA Johnstone – volume: 412 start-page: 150 issue: 6843 year: 2001 ident: 196_CR23 publication-title: Nature doi: 10.1038/35084005 contributor: fullname: NK Logothetis |
SSID | ssj0017814 |
Score | 1.7945937 |
Snippet | Clinical studies suggest that acupuncture can stimulate saliva production and reduce xerostomia (dry mouth). We were interested in exploring the neuronal... Background Clinical studies suggest that acupuncture can stimulate saliva production and reduce xerostomia (dry mouth). We were interested in exploring the... BACKGROUNDClinical studies suggest that acupuncture can stimulate saliva production and reduce xerostomia (dry mouth). We were interested in exploring the... BACKGROUND: Clinical studies suggest that acupuncture can stimulate saliva production and reduce xerostomia (dry mouth). We were interested in exploring the... Abstract Background Clinical studies suggest that acupuncture can stimulate saliva production and reduce xerostomia (dry mouth). We were interested in... |
SourceID | doaj pubmedcentral biomedcentral proquest gale crossref pubmed |
SourceType | Open Website Open Access Repository Aggregation Database Index Database |
StartPage | 37 |
SubjectTerms | Acupuncture Acupuncture Points Acupuncture Therapy - methods Adult Female Health aspects Humans Magnetic Resonance Imaging Male Methods Parotid Gland - secretion Physiological aspects Reference Values Saliva - secretion Xerostomia - prevention & control |
SummonAdditionalLinks | – databaseName: Open Access: BioMedCentral Open Access Titles dbid: RBZ link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LbxMxELagSIgL4k2gUB-QgMOKXa9f21uLiFpEOCAqVVwsP0ukZhM1yYU_w19lZneb1o164rayx9bKM-MZj2c-E_KuSVz56HkhPU8F5w50rmx8EWSUvHS-Sl024eS7PDrhX0_F6VW848YNfqXlp4orVkh0BDVow11yjyHEOZ7LD39t7gsQuKmrIxpoB3jG7fE36trPM3PUofZv783XjFOeOHnNEo0fkYeDC0kPep4_Jndi-4TcnwyX5E_J3zHYqj7ER2f2rMUyRQqn6jlia0Q6nXUPE9EPafLj-CPtK3-X1LaBLi1eDNFFjwILM1A7cC8GihFbav16gbOvLyK1K_rtuGBZ22I-bVf71FIwgWE-m_6BgUM2_Dl8dmC2z8jJ-MvPz0fF8A5D4YRWqhA-JebrhCFTZwVPTqlQR-4qHhvhGFOxAQsoQtAB9LmOFrp10FZH4cqo6-dkp5238SWhzgWbbFkGGSycXJOrLaL1aOd5qXloRmQ_Y49Z9JgbBlGw8x5QSIO8Nchbo02tRuT9JS8347ozjpZblIfI6mz2rgEEzwwqa5qgGJeJqVA6bmvWyCZGrhKvU7KwDY7IHgqK6QtWNzuFOQCnSYDnrDT8UEeBewX8s7dDyQOsBaJuZZS7GSXouM-69y6F0WAXJsa1cb5emgrx8ZtK3E7B8CVnWcnbKWRTw6FYwhwvevG-Wj0tEa8H2KIywc8WLu9pp787kHLGFReKvfofhr4mD_r0HIym75Kd1cU6vgEfcOXedur_D7mDXPs priority: 500 providerName: BioMedCentral – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQD4gL4s1CoT4gAYeoieNXeiuIVYtYDohKvVl-wkrdZNXdvfBn-KvMJNllrariwi2yJ1biGc_DnvlMyJsmceWj54X0PBWcO1hzZeOLIKPkpfNV6rMJZ1_l2QX_fCku9676wpywAR54mLjjJijGZWIqlI7bmjWyiZGrxOuULAhjr30rsQ2mxvMDBHLq64oUKyQ4kSNcY6Xl8a6t0AXefp7VuV9l5qlH8b-pq_eMVZ5IuWeZpg_I_dGlpKfDrzwkd2L7iNydjYfmj8nvKdiuYcuPLuyPFssWKUTZHWJtRDpf9BcV0Xdp9u38PR0qgVfUtoGuLB4U0eWACgsjUDtyMwaKO7jU-s0SR99cR2rX9Mt5wbK2ZTdv1yfUUjCJoVvMf8GLY3b8FTz24LZPyMX00_ePZ8V4L0PhhFaqED4l5uuEW6jOCp6cUqGO3FU8NsIxpmIDFlGEoAOs7zpa6NZBWx2FK6Oun5KDtmvjc0KdCzbZsgwyWIhkk6stovdo53mpeWgm5CRjj1kOGBwGUbHzHligBnlrkLdGm1pNyNstL3fv9TGPljcoPyCrs9H7BpBEM0qi-ZckTsgRCooZClh3msOcghMlwJNWGj6op0DdAd_s7VgCAXOBKFwZ5WFGCWveZ91HW2E02IWJcm3sNitTIV5-U4nbKRje7CwreTuFbGoIkiWM8WwQ77-zpyXi9wBbVCb42cTlPe38Zw9azrjiQrEX_2OmX5J7Q9oO7rIfkoP19Sa-At9w7V73auAPTc1kzg priority: 102 providerName: Directory of Open Access Journals – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3di9QwEA96gvgifrt6enkQfKq2aZqkByKneJzi-uTCvYV8ngu77bofoP4l_rnOtL3bi-uBbyUzCSUzk8kkM78Q8qKOXLrgeCYcjxnnFmwur13mRRA8t66IXTbh-Is4mfBPp9XpNv9pmMDVP0M7fE9qspy9-vH951sw-DedwSvxuuCSZQK3igrs5Tq5wXjJUdvHfHujgNBOXaXRwDsAOO72_6vyfZY4rA7Xf3f1vuS-0tTKS77q-A65PWwy6VGvFXfJtdDcIzfHwzX6ffL7GLxZfwhI5-aswUJGCnF3i-gbgU7n3dNFtC8KXlHTeLoyeGdEFz1ALHSlZhBs8BQPc6lxmwUOu1kGatb088eMJW2LdtqsD6mh4B19O5_-go5DovwMPjuc2wdkcvzh6_uTbHiiIbOVkjKrXIzMlRFPU62peLRS-jJwW_BQV5YxGWpwjpX3yoOpl8EAWXllVKhsHlT5kOw1bRMeE2qtN9HkuRfeQFAbbWkQyEdZx3PFfT0ih4lc9KKH49AIkJ1SwFY1ClWjULXSpRyRl-dCvOjXhT9K7HC-Qxkno3cN7fJMD9asay8ZF5FJn1tuSlaLOgQuIy9jNLBCjsgBaojua1kvFhF9BPupCjbVUsEPdRyo2PDPzgzVEDAXCMiVcO4nnGD-LiEfnGuhRhLmzDWh3ax0gdD5dVFdzcHwkWdRiKs5RF1CvCxgjEe9Xm9nTwmE8gGxyETjk4lLKc30W4dfzrjklWRP_nsKnpJbfZoOnqrvk731chOewV5wbZ93Rv4Hvg1hDA priority: 102 providerName: Scholars Portal |
Title | Functional magnetic resonance imaging (fMRI) changes and saliva production associated with acupuncture at LI-2 acupuncture point: a randomized controlled study |
URI | https://www.ncbi.nlm.nih.gov/pubmed/18606019 https://search.proquest.com/docview/19355915 https://search.proquest.com/docview/21057616 https://search.proquest.com/docview/69314865 http://dx.doi.org/10.1186/1472-6882-8-37 https://pubmed.ncbi.nlm.nih.gov/PMC2474572 https://doaj.org/article/9d7246f27d0b4a32969ee47f43ffa225 |
Volume | 8 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LbxMxELbaHhAXxJtAaX1AAg7b7MNre3trK6oWEYQqKlVcLD9LpGQT5XHhz_BXmfFuSk3VCxdrtR5blmfG47FnPhPyrglMWG9Zxi0LGWMGdC5vbOa45yw3tggxmnD0lZ9dss9X9dUWqTe5MDFo35rxQTuZHrTjnzG2cj61w02c2PDb6KRkgtWiHG6TbVFVGxe9vzpADKcenbGQfFgwUWYc95ESlAkxQiVHDJLmnwz3SWKYIn7_3VX6lplKQyhv2aTTx-RRv5mkR92gn5At3z4lD0b9dfkz8vsUrFZ32Een-rrFhEUK_vUMUTY8HU_jE0X0QxhdnH-kXQ7wkurW0aXGKyI67_BgoQeqez56R_Hslmq7nmPv64WnekW_nGdl8m8-G7erQ6opGEM3m45_QcM-Ln4CnxHW9jm5PP30_eQs619kyEwthchqG0Jpq4CHp0bXLBghXOWZKZhvalOWwjdgC2vnpAPNrryGaumklr42uZfVC7LTzlr_ilBjnA46zx13GnzYYCqNuD3SWJZL5poBOUzYo-Yd-oZCPOy0BlRTIZsVsllJVYkBeb_h5U276O1IfofyGFmd9B5_zBbXqpc51ThRMh5K4XLDdFU2vPGeicCqEDQsiAOyj4KiutTVmzVDHcH2qQZRExIGFClw1YAxW90nP8BcIP5WQrmbUIK226R6fyOMCqswRK71s_VSFYiU3xT1_RQlvunMC34_BW8qcI859PGyE--_s9drzYCIRPCTiUtrQHsjXHmvra__u-Ub8rCL0sFD9V2ys1qs_VvYCq7MXjxCgXLEJJQXxz_24mLwB5Q0Zmw |
link.rule.ids | 108,230,315,733,786,790,870,891,2115,2236,24346,24965,27957,27958,53827,53829,76169,76170 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LbxMxELZKkYAL70KgEB-QgMMm-_Da3t5KRZRAUiHUot4sP0tEshvlcemf4a8y3t2UulUPcFvtjK21dx4ee-YzQu8KR5i2mkRUExcRokDn4kJHhlpKYqUTV2cTTo7p8JR8OcvPdlC-rYWpk_a1mvbK2bxXTn_WuZWLue5v88T63yZHKWEkZ2n_DroL-pqybZDeHh54FKcWnzHhtJ8QlkbUryQ5qJNHCeXUo5AU12rcZ4FrqhH8b9rpK44qTKK84pUGj9CP7XiaZJRfvc1a9fTFNajHfx7wY_SwXafiw4b8BO3Y8im6N2lP4p-h3wNwiM0-Ip7L89LXQmII3SsP4GHxdF7ffoQ_uMn30UfclBevsCwNXkl_-oQXDdQs9IBlKyLWYL8tjKXeLHzvm6XFco3HoygN3i2qabk-wBKDnzXVfHoBDduU-xk81oi5z9Hp4PPJ0TBqL3uIVM4Zi3LtXKoz5_dllcyJU4yZzBKVEFvkKk2ZLcDN5sZwA0YjsxLI3HDJba5iy7M9tFtWpX2JsFJGOhnHhhoJ4bFTmfSQQFxpEnNiig46CP67WDTAHsJDbYcU0Hrh5Ud4-RFcZKyD3m-F5LJdHUhxeoPzk5ehoPf6RbU8F-3fFYVhKaEuZSZWRGZpQQtrCXMkc06Cre2grpdA0VTFXpojcQgrsxxkmHH4oJrDGyT4Zi3bugqYCw_tFXDuB5xgSHRA7m6lXHiSz74rbbVZicSD8BdJfjtH6q-Lpgm9nYMWGUTeFPp40ejN39lr1bGDWKBRwcSFFNCTGgm91YtX_92yi-4PTyZjMR4df32NHjTJQH7vfh_trpcb-wZWnGv1trYvfwDD1oWF |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagSBUX3pSFQn1AAg7ZTRzHdnorhVUXulWFqFRxsfwsK3aTaB-X_hn-KuMkWzateuktyoyt2JmHx575jND73FNunKERM9RHlGrQuTg3kWWO0VibxNfZhOMTdnRGv51n5xtXfdVJ-0ZP-sV01i8mv-vcympmBus8scHp-JBQTjNOBpX1g_voAegsydeBenuAEJCcWozGRLBBQjmJWFhNClCpgBQqWEAiya_VuU877qlG8b9pqzecVTeRcsMzDR-jX-sxNQkpf_qrpe6by2twj3ca9BP0qF2v4oOG5Sm654pnaHvcnsg_R3-H4Bib_UQ8UxdFqInEEMKXAcjD4cmsvgUJf_TjH6NPuCkzXmBVWLxQ4RQKVw3kLPSAVSsqzuKwPYyVWVWh99XcYbXEx6OIdN5V5aRY7mOFwd_acja5hIZt6v0UHmvk3BfobPj15-FR1F76EOlMcB5lxntiUh_2Z7XKqNec29RRnVCXZ5oQ7nJwt5m1woLxSJ0CsrBCCZfp2In0JdoqysK9Qlhrq7yKY8usgjDZ61QFaCChDY0FtXkP7Xf-vawagA8ZILe7FNB-GWRIBhmSQqa8hz6sBeWqXR1QCXaD83OQo07v9YtyfiHbPyxzywllnnAba6pSkrPcOco9Tb1XYHN7aC9IoWyqY6_MkjyAFVoGcswFfFDNEQwTfLNRbX0FzEWA-Opw7nY4waCYDnlvLekykEIWXuHK1UImAYw_T7LbOUi4Npol7HYOlqcQgTPoY6fRnf-z16pkD_GOVnUmrksBXakR0VvdeH3nlnto-_TLUB6PTr6_QQ-bnKCwhb-LtpbzlXsLC8-lflebmH-Zl4gF |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Functional+magnetic+resonance+imaging+changes+and+saliva+production+associated+with+acupuncture+at+LI-2+acupuncture+point%3A+a+randomized+controlled+study&rft.jtitle=BMC+complementary+and+alternative+medicine&rft.au=Deng%2C+Gary&rft.au=Hou%2C+Bob+L&rft.au=Holodny%2C+Andrei+I&rft.au=Cassileth%2C+Barrie+R&rft.date=2008-07-07&rft.pub=BioMed+Central+Ltd&rft.issn=1472-6882&rft.eissn=1472-6882&rft.volume=8&rft.spage=37&rft_id=info:doi/10.1186%2F1472-6882-8-37&rft.externalDocID=A181501978 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1472-6882&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1472-6882&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1472-6882&client=summon |