The eukaryotic flagellum makes the day: novel and unforeseen roles uncovered after post-genomics and proteomics data
This review will summarize and discuss the current biological understanding of the motile eukaryotic flagellum, as posed out by recent advances enabled by post-genomics and proteomics approaches. The organelle, which is crucial for motility, survival, differentiation, reproduction, division and feed...
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| Published in | Current protein & peptide science Vol. 13; no. 6; p. 524 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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United Arab Emirates
01.09.2012
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| Abstract | This review will summarize and discuss the current biological understanding of the motile eukaryotic flagellum, as posed out by recent advances enabled by post-genomics and proteomics approaches. The organelle, which is crucial for motility, survival, differentiation, reproduction, division and feeding, among other activities, of many eukaryotes, is a great example of a natural nanomachine assembled mostly by proteins (around 350-650 of them) that have been conserved throughout eukaryotic evolution. Flagellar proteins are discussed in terms of their arrangement on to the axoneme, the canonical "9+2" microtubule pattern, and also motor and sensorial elements that have been detected by recent proteomic analyses in organisms such as Chlamydomonas reinhardtii, sea urchin, and trypanosomatids. Such findings can be remarkably matched up to important discoveries in vertebrate and mammalian types as diverse as sperm cells, ciliated kidney epithelia, respiratory and oviductal cilia, and neuro-epithelia, among others. Here we will focus on some exciting work regarding eukaryotic flagellar proteins, particularly using the flagellar proteome of C. reinhardtii as a reference map for exploring motility in function, dysfunction and pathogenic flagellates. The reference map for the eukaryotic flagellar proteome consists of 652 proteins that include known structural and intraflagellar transport (IFT) proteins, less wellcharacterized signal transduction proteins and flagellar associated proteins (FAPs), besides almost two hundred unannotated conserved proteins, which lately have been the subject of intense investigation and of our present examination. |
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| AbstractList | This review will summarize and discuss the current biological understanding of the motile eukaryotic flagellum, as posed out by recent advances enabled by post-genomics and proteomics approaches. The organelle, which is crucial for motility, survival, differentiation, reproduction, division and feeding, among other activities, of many eukaryotes, is a great example of a natural nanomachine assembled mostly by proteins (around 350-650 of them) that have been conserved throughout eukaryotic evolution. Flagellar proteins are discussed in terms of their arrangement on to the axoneme, the canonical "9+2" microtubule pattern, and also motor and sensorial elements that have been detected by recent proteomic analyses in organisms such as Chlamydomonas reinhardtii, sea urchin, and trypanosomatids. Such findings can be remarkably matched up to important discoveries in vertebrate and mammalian types as diverse as sperm cells, ciliated kidney epithelia, respiratory and oviductal cilia, and neuro-epithelia, among others. Here we will focus on some exciting work regarding eukaryotic flagellar proteins, particularly using the flagellar proteome of C. reinhardtii as a reference map for exploring motility in function, dysfunction and pathogenic flagellates. The reference map for the eukaryotic flagellar proteome consists of 652 proteins that include known structural and intraflagellar transport (IFT) proteins, less wellcharacterized signal transduction proteins and flagellar associated proteins (FAPs), besides almost two hundred unannotated conserved proteins, which lately have been the subject of intense investigation and of our present examination. |
| Author | de Oliveira, Diana M Farias, Kaio M Diniz, Michely C Pacheco, Ana Carolina L |
| Author_xml | – sequence: 1 givenname: Michely C surname: Diniz fullname: Diniz, Michely C organization: Programa de Pós-Graduação em Biotecnologia-RENORBIO-Rede Nordeste de Biotecnologia, Universidade Estadual do Ceará-UECE, Av. Paranjana, 1700, Campus do Itaperi, Fortaleza, CE 60740-000 Brasil – sequence: 2 givenname: Ana Carolina L surname: Pacheco fullname: Pacheco, Ana Carolina L – sequence: 3 givenname: Kaio M surname: Farias fullname: Farias, Kaio M – sequence: 4 givenname: Diana M surname: de Oliveira fullname: de Oliveira, Diana M |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22708495$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_theriogenology_2019_06_005 crossref_primary_10_3389_fmicb_2015_00190 crossref_primary_10_1016_j_pt_2018_08_002 crossref_primary_10_15252_embr_202051030 crossref_primary_10_1038_s12276_018_0108_z crossref_primary_10_1016_j_semcdb_2015_10_034 crossref_primary_10_1186_s12864_022_09035_0 crossref_primary_10_3389_fgene_2021_783790 crossref_primary_10_3390_bioengineering10080893 crossref_primary_10_1016_j_ceb_2016_05_004 crossref_primary_10_1071_RD15492 crossref_primary_10_1002_cm_21295 crossref_primary_10_1111_nph_17638 crossref_primary_10_1371_journal_pone_0129151 |
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| SubjectTerms | Animals Eukaryotic Cells - cytology Flagella - genetics Flagella - metabolism Humans Microfilament Proteins - genetics Microfilament Proteins - metabolism Movement Nanostructures Proteomics - methods |
| Title | The eukaryotic flagellum makes the day: novel and unforeseen roles uncovered after post-genomics and proteomics data |
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