Translation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized Phase I trial - Le Lamer, Sophie; Paradis, Stéphanie; Rahmouni, Hidayat; Chaimbault, Corinne; Michaud, Magali; Culcasi, Marcel; Afxantidis, Jean; Latreille, Mathilde; Berna, Patrick; Berdeaux, Alain; Pietri, Sylvia; Morin, Didier; et al. (Journal of translational medicine, 2014)
Keywords: Animals; Biochemistry, Molecular Biology; Clinical trials; Disease Models, Animal; Dose-Response Relationship, Drug; Experiments; Female; Healthy Volunteers; Heart; Heart attacks; Human health and pathology; Humans; In Vitro Techniques; Ischemia; Life Sciences; Liposomes; Male; Mitochondria; Mortality; Myocardial Infarction - blood; Myocardial Infarction - complications; Myocardial Infarction - drug therapy; Myocardial Infarction - pathology; Myocardial Reperfusion Injury - blood; Myocardial Reperfusion Injury - complications; Myocardial Reperfusion Injury - drug therapy; Myocardial Reperfusion Injury - pathology; Oxidative Stress - drug effects; Oximes - adverse effects; Oximes - blood; Oximes - pharmacology; Oximes - therapeutic use; Permeability; Rats; Rodents; Secosteroids - adverse effects; Secosteroids - blood; Secosteroids - pharmacology; Secosteroids - therapeutic use; Studies; Sus scrofa; Translational Medical Research; Phase I clinical tria; Functional recovery; Acute myocardial infarction; Mitochondrial permeability transition pore