Introduction of a new model for time-continuous and non-contact investigations of in-vitro thrombolysis under physiological flow conditions
Thrombolysis is a dynamic and time-dependent process influenced by the haemodynamic conditions. Currently there is no model that allows for time-continuous, non-contact measurements under physiological flow conditions. The aim of this work was to introduce such a model. The model is based on a compu...
Saved in:
Published in | BMC neurology Vol. 11; no. 1; p. 58 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
BioMed Central Ltd
26.05.2011
BioMed Central BMC |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Thrombolysis is a dynamic and time-dependent process influenced by the haemodynamic conditions. Currently there is no model that allows for time-continuous, non-contact measurements under physiological flow conditions. The aim of this work was to introduce such a model.
The model is based on a computer-controlled pump providing variable constant or pulsatile flows in a tube system filled with blood substitute. Clots can be fixed in a custom-built clot carrier within the tube system. The pressure decline at the clot carrier is measured as a novel way to measure lysis of the clot. With different experiments the hydrodynamic properties and reliability of the model were analyzed. Finally, the lysis rate of clots generated from human platelet rich plasma (PRP) was measured during a one hour combined application of diagnostic ultrasound (2 MHz, 0.179 W/cm2) and a thrombolytic agent (rt-PA) as it is commonly used for clinical sonothrombolysis treatments.
All hydrodynamic parameters can be adjusted and measured with high accuracy. First experiments with sonothrombolysis demonstrated the feasibility of the model despite low lysis rates.
The model allows to adjust accurately all hydrodynamic parameters affecting thrombolysis under physiological flow conditions and for non-contact, time-continuous measurements. Low lysis rates of first sonothrombolysis experiments are primarily attributable to the high stability of the used PRP-clots. |
---|---|
AbstractList | Background Thrombolysis is a dynamic and time-dependent process influenced by the haemodynamic conditions. Currently there is no model that allows for time-continuous, non-contact measurements under physiological flow conditions. The aim of this work was to introduce such a model. Methods The model is based on a computer-controlled pump providing variable constant or pulsatile flows in a tube system filled with blood substitute. Clots can be fixed in a custom-built clot carrier within the tube system. The pressure decline at the clot carrier is measured as a novel way to measure lysis of the clot. With different experiments the hydrodynamic properties and reliability of the model were analyzed. Finally, the lysis rate of clots generated from human platelet rich plasma (PRP) was measured during a one hour combined application of diagnostic ultrasound (2 MHz, 0.179 W/cm.sup.2.sup.) and a thrombolytic agent (rt-PA) as it is commonly used for clinical sonothrombolysis treatments. Results All hydrodynamic parameters can be adjusted and measured with high accuracy. First experiments with sonothrombolysis demonstrated the feasibility of the model despite low lysis rates. Conclusions The model allows to adjust accurately all hydrodynamic parameters affecting thrombolysis under physiological flow conditions and for non-contact, time-continuous measurements. Low lysis rates of first sonothrombolysis experiments are primarily attributable to the high stability of the used PRP-clots. Thrombolysis is a dynamic and time-dependent process influenced by the haemodynamic conditions. Currently there is no model that allows for time-continuous, non-contact measurements under physiological flow conditions. The aim of this work was to introduce such a model. The model is based on a computer-controlled pump providing variable constant or pulsatile flows in a tube system filled with blood substitute. Clots can be fixed in a custom-built clot carrier within the tube system. The pressure decline at the clot carrier is measured as a novel way to measure lysis of the clot. With different experiments the hydrodynamic properties and reliability of the model were analyzed. Finally, the lysis rate of clots generated from human platelet rich plasma (PRP) was measured during a one hour combined application of diagnostic ultrasound (2 MHz, 0.179 W/cm.sup.2.sup.) and a thrombolytic agent (rt-PA) as it is commonly used for clinical sonothrombolysis treatments. All hydrodynamic parameters can be adjusted and measured with high accuracy. First experiments with sonothrombolysis demonstrated the feasibility of the model despite low lysis rates. The model allows to adjust accurately all hydrodynamic parameters affecting thrombolysis under physiological flow conditions and for non-contact, time-continuous measurements. Low lysis rates of first sonothrombolysis experiments are primarily attributable to the high stability of the used PRP-clots. Abstract Background Thrombolysis is a dynamic and time-dependent process influenced by the haemodynamic conditions. Currently there is no model that allows for time-continuous, non-contact measurements under physiological flow conditions. The aim of this work was to introduce such a model. Methods The model is based on a computer-controlled pump providing variable constant or pulsatile flows in a tube system filled with blood substitute. Clots can be fixed in a custom-built clot carrier within the tube system. The pressure decline at the clot carrier is measured as a novel way to measure lysis of the clot. With different experiments the hydrodynamic properties and reliability of the model were analyzed. Finally, the lysis rate of clots generated from human platelet rich plasma (PRP) was measured during a one hour combined application of diagnostic ultrasound (2 MHz, 0.179 W/cm2) and a thrombolytic agent (rt-PA) as it is commonly used for clinical sonothrombolysis treatments. Results All hydrodynamic parameters can be adjusted and measured with high accuracy. First experiments with sonothrombolysis demonstrated the feasibility of the model despite low lysis rates. Conclusions The model allows to adjust accurately all hydrodynamic parameters affecting thrombolysis under physiological flow conditions and for non-contact, time-continuous measurements. Low lysis rates of first sonothrombolysis experiments are primarily attributable to the high stability of the used PRP-clots. Thrombolysis is a dynamic and time-dependent process influenced by the haemodynamic conditions. Currently there is no model that allows for time-continuous, non-contact measurements under physiological flow conditions. The aim of this work was to introduce such a model. The model is based on a computer-controlled pump providing variable constant or pulsatile flows in a tube system filled with blood substitute. Clots can be fixed in a custom-built clot carrier within the tube system. The pressure decline at the clot carrier is measured as a novel way to measure lysis of the clot. With different experiments the hydrodynamic properties and reliability of the model were analyzed. Finally, the lysis rate of clots generated from human platelet rich plasma (PRP) was measured during a one hour combined application of diagnostic ultrasound (2 MHz, 0.179 W/cm2) and a thrombolytic agent (rt-PA) as it is commonly used for clinical sonothrombolysis treatments. All hydrodynamic parameters can be adjusted and measured with high accuracy. First experiments with sonothrombolysis demonstrated the feasibility of the model despite low lysis rates. The model allows to adjust accurately all hydrodynamic parameters affecting thrombolysis under physiological flow conditions and for non-contact, time-continuous measurements. Low lysis rates of first sonothrombolysis experiments are primarily attributable to the high stability of the used PRP-clots. BACKGROUNDThrombolysis is a dynamic and time-dependent process influenced by the haemodynamic conditions. Currently there is no model that allows for time-continuous, non-contact measurements under physiological flow conditions. The aim of this work was to introduce such a model. METHODSThe model is based on a computer-controlled pump providing variable constant or pulsatile flows in a tube system filled with blood substitute. Clots can be fixed in a custom-built clot carrier within the tube system. The pressure decline at the clot carrier is measured as a novel way to measure lysis of the clot. With different experiments the hydrodynamic properties and reliability of the model were analyzed. Finally, the lysis rate of clots generated from human platelet rich plasma (PRP) was measured during a one hour combined application of diagnostic ultrasound (2 MHz, 0.179 W/cm2) and a thrombolytic agent (rt-PA) as it is commonly used for clinical sonothrombolysis treatments. RESULTSAll hydrodynamic parameters can be adjusted and measured with high accuracy. First experiments with sonothrombolysis demonstrated the feasibility of the model despite low lysis rates. CONCLUSIONSThe model allows to adjust accurately all hydrodynamic parameters affecting thrombolysis under physiological flow conditions and for non-contact, time-continuous measurements. Low lysis rates of first sonothrombolysis experiments are primarily attributable to the high stability of the used PRP-clots. BACKGROUND: Thrombolysis is a dynamic and time-dependent process influenced by the haemodynamic conditions. Currently there is no model that allows for time-continuous, non-contact measurements under physiological flow conditions. The aim of this work was to introduce such a model. METHODS: The model is based on a computer-controlled pump providing variable constant or pulsatile flows in a tube system filled with blood substitute. Clots can be fixed in a custom-built clot carrier within the tube system. The pressure decline at the clot carrier is measured as a novel way to measure lysis of the clot. With different experiments the hydrodynamic properties and reliability of the model were analyzed. Finally, the lysis rate of clots generated from human platelet rich plasma (PRP) was measured during a one hour combined application of diagnostic ultrasound (2 MHz, 0.179 W/cm2) and a thrombolytic agent (rt-PA) as it is commonly used for clinical sonothrombolysis treatments. RESULTS: All hydrodynamic parameters can be adjusted and measured with high accuracy. First experiments with sonothrombolysis demonstrated the feasibility of the model despite low lysis rates. CONCLUSIONS: The model allows to adjust accurately all hydrodynamic parameters affecting thrombolysis under physiological flow conditions and for non-contact, time-continuous measurements. Low lysis rates of first sonothrombolysis experiments are primarily attributable to the high stability of the used PRP-clots. |
ArticleNumber | 58 |
Audience | Academic |
Author | Trillenberg, Peter Weber, Peter-Karl Schmieger, Marc Roessler, Florian C Ohlrich, Marcus Seidel, Günter Stellmacher, Florian Marxsen, Jan H Eggers, Jürgen |
AuthorAffiliation | 4 Research Centre Borstel, Clinical and Experimental Pathology, Parkallee 3a, 23845 Borstel, Germany 2 Department of Internal Medicine, Haematology, University Hospital of Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany 5 Department of Neurology, Asklepios Klinik Nord, Langstedter Landstr. 400, 22417 Hamburg, Germany 1 Department of Neurology, University Hospital of Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany 3 Fraunhofer Institute for Biomedical Engineering (IBMT), Ultrasound Systems Development, Ensheimer Str. 48, 66386 St. Ingbert, Germany |
AuthorAffiliation_xml | – name: 3 Fraunhofer Institute for Biomedical Engineering (IBMT), Ultrasound Systems Development, Ensheimer Str. 48, 66386 St. Ingbert, Germany – name: 2 Department of Internal Medicine, Haematology, University Hospital of Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany – name: 1 Department of Neurology, University Hospital of Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany – name: 5 Department of Neurology, Asklepios Klinik Nord, Langstedter Landstr. 400, 22417 Hamburg, Germany – name: 4 Research Centre Borstel, Clinical and Experimental Pathology, Parkallee 3a, 23845 Borstel, Germany |
Author_xml | – sequence: 1 givenname: Florian C surname: Roessler fullname: Roessler, Florian C email: florian.roessler@neuro.uni-luebeck.de organization: Department of Neurology, University Hospital of Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. florian.roessler@neuro.uni-luebeck.de – sequence: 2 givenname: Marcus surname: Ohlrich fullname: Ohlrich, Marcus – sequence: 3 givenname: Jan H surname: Marxsen fullname: Marxsen, Jan H – sequence: 4 givenname: Marc surname: Schmieger fullname: Schmieger, Marc – sequence: 5 givenname: Peter-Karl surname: Weber fullname: Weber, Peter-Karl – sequence: 6 givenname: Florian surname: Stellmacher fullname: Stellmacher, Florian – sequence: 7 givenname: Peter surname: Trillenberg fullname: Trillenberg, Peter – sequence: 8 givenname: Jürgen surname: Eggers fullname: Eggers, Jürgen – sequence: 9 givenname: Günter surname: Seidel fullname: Seidel, Günter |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21615905$$D View this record in MEDLINE/PubMed |
BookMark | eNp1kktr3DAUhU1JaR7tursi6KIrJ3rZkjeFJPQxEOimXQs9PQq2NJXsCfkN_dOVZ9IhAyleWDr33I8rHZ1XJyEGW1XvEbxEiLdXiDJUY8JYjVDd8FfV2UE5ebY-rc5zvocQMU7Rm-oUoxY1HWzOqj-rMKVoZj35GEB0QIJgH8AYjR2AiwlMfrS1jmHyYY5zBjIYUIbYSVJPwIetzZPv5QLIC8GHeusLFEzrFEcVh8fsM5iDsQls1mUTh9h7LQt_iA-ggIzfNb-tXjs5ZPvu6X9R_fr65eft9_rux7fV7fVdrRpOp1pTRTFn0BiMu66sMHe2oUZ1qkjGOaJoqx1pIUPOsJZp2RCkGmI0JlYxclGt9lwT5b3YJD_K9Cii9GInxNQLmSavByuIailpDSeYOIqo44jaBmnECCwlYwrr8561mdVojbblOuVwBD2uBL8WfdwKgnDLYFsAN3uA8vE_gOOKjqNYghVLsAIh0fAC-fQ0RYq_55KHGH3WdhhksCU0wRmlHDPcFefHvbOX5Xg-uFigenGLa9xC2CHCaHFdvuAqn7GjL4FZ54t-1HC1b9Ap5pysOxwAQbG81BdG_vD84g7-f0-T_AVHo-ji |
CitedBy_id | crossref_primary_10_3390_pharmaceutics12121207 crossref_primary_10_1002_btm2_10511 crossref_primary_10_1016_j_jneumeth_2014_08_025 crossref_primary_10_1016_S1773_2247_12_50065_1 crossref_primary_10_1038_s41598_017_06089_z |
Cites_doi | 10.1016/S0301-5629(99)00095-2 10.1161/01.CIR.86.4.1257 10.1161/STROKEAHA.107.503870 10.1161/01.STR.31.3.610 10.1088/0031-9155/52/11/003 10.1161/01.CIR.102.2.238 10.1088/0031-9155/53/23/012 10.1159/000086122 10.1007/s11239-007-0044-6 10.1161/01.STR.0000199064.94588.39 10.1016/0301-5629(94)90006-X 10.1177/152660280301000119 10.1148/radiol.2391042181 10.1111/j.1540-8191.1993.tb00384.x 10.1016/S0006-3495(93)81314-6 10.1016/S0301-5629(01)00481-1 10.1016/S1051-0443(07)61465-1 10.1159/000185611 10.1212/01.wnl.0000260604.26469.8e 10.1161/01.CIR.98.10.1030 10.1055/s-0037-1613838 10.1159/000230710 10.1056/NEJMoa041175 10.1016/S0301-5629(98)00158-6 10.1212/01.WNL.0000154599.45969.D6 10.1016/0735-1097(93)90331-T 10.1161/01.STR.0000257314.74853.2b 10.1161/01.STR.0000150503.10480.a7 10.1007/978-3-7091-8864-4 10.1016/j.thromres.2007.07.006 10.1016/j.athoracsur.2009.10.041 |
ContentType | Journal Article |
Copyright | COPYRIGHT 2011 BioMed Central Ltd. Copyright ©2011 Roessler et al; licensee BioMed Central Ltd. 2011 Roessler et al; licensee BioMed Central Ltd. |
Copyright_xml | – notice: COPYRIGHT 2011 BioMed Central Ltd. – notice: Copyright ©2011 Roessler et al; licensee BioMed Central Ltd. 2011 Roessler et al; licensee BioMed Central Ltd. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM DOA |
DOI | 10.1186/1471-2377-11-58 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1471-2377 |
EndPage | 58 |
ExternalDocumentID | oai_doaj_org_article_3b6436d8323f414f814e51c17303b6dd oai_biomedcentral_com_1471_2377_11_58 A260091374 10_1186_1471_2377_11_58 21615905 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GeographicLocations | Germany |
GeographicLocations_xml | – name: Germany |
GroupedDBID | --- -A0 0R~ 23N 2VQ 2WC 3V. 4.4 53G 5VS 6J9 6PF 7X7 88E 8FI 8FJ AAFWJ AAJSJ AAWTL ABDBF ABIVO ABUWG ACGFO ACGFS ACIHN ACPRK ACRMQ ADBBV ADINQ ADRAZ ADUKV AEAQA AENEX AFKRA AFPKN AHBYD AHMBA AHSBF AHYZX ALIPV ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS BAPOH BAWUL BCNDV BENPR BFQNJ BMC BPHCQ BVXVI C1A C24 C6C CCPQU CGR CS3 CUY CVF DIK DU5 E3Z EAD EAP EAS EBD EBLON EBS ECM EIF EJD EMB EMK EMOBN ESX F5P FYUFA GROUPED_DOAJ GX1 H13 HMCUK HYE IAO IGS IHR INH INR IPNFZ ITC KQ8 M1P M48 M~E NPM O5R O5S OK1 P2P PGMZT PIMPY PQQKQ PROAC PSQYO RBZ RIG RNS ROL RPM RSV SMD SOJ SV3 TR2 TUS UKHRP W2D WOQ WOW XSB AAYXX CITATION ABVAZ AFGXO AFNRJ 7X8 5PM |
ID | FETCH-LOGICAL-b584t-c4b42870dd229928728fe54db9bdd2dff3b46cf36071fd767ca531b53dc23eb73 |
IEDL.DBID | RPM |
ISSN | 1471-2377 |
IngestDate | Fri Oct 04 13:12:52 EDT 2024 Tue Sep 17 21:09:13 EDT 2024 Tue Apr 16 22:45:31 EDT 2024 Thu Aug 15 23:29:52 EDT 2024 Thu Feb 22 23:48:51 EST 2024 Fri Feb 02 04:07:41 EST 2024 Thu Sep 12 18:21:11 EDT 2024 Sat Sep 28 07:48:55 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Language | English |
License | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-b584t-c4b42870dd229928728fe54db9bdd2dff3b46cf36071fd767ca531b53dc23eb73 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126706/ |
PMID | 21615905 |
PQID | 874482729 |
PQPubID | 23479 |
PageCount | 1 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_3b6436d8323f414f814e51c17303b6dd pubmedcentral_primary_oai_pubmedcentral_nih_gov_3126706 biomedcentral_primary_oai_biomedcentral_com_1471_2377_11_58 proquest_miscellaneous_874482729 gale_infotracmisc_A260091374 gale_infotracacademiconefile_A260091374 crossref_primary_10_1186_1471_2377_11_58 pubmed_primary_21615905 |
PublicationCentury | 2000 |
PublicationDate | 2011-05-26 |
PublicationDateYYYYMMDD | 2011-05-26 |
PublicationDate_xml | – month: 05 year: 2011 text: 2011-05-26 day: 26 |
PublicationDecade | 2010 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | BMC neurology |
PublicationTitleAlternate | BMC Neurol |
PublicationYear | 2011 |
Publisher | BioMed Central Ltd BioMed Central BMC |
Publisher_xml | – name: BioMed Central Ltd – name: BioMed Central – name: BMC |
References | 16493016 - Radiology. 2006 Apr;239(1):86-93 15925878 - Cerebrovasc Dis. 2005;20(1):18-22 17452580 - Neurology. 2007 Apr 24;68(17):1364-8 19641311 - Cerebrovasc Dis. 2009;28(4):365-70 1394932 - Circulation. 1992 Oct;86(4):1257-64 10716390 - J Vasc Interv Radiol. 2000 Feb;11(2 Pt 1):199-205 17505083 - Phys Med Biol. 2007 Jun 7;52(11):2969-85 10744155 - Thromb Haemost. 2000 Mar;83(3):469-74 17514430 - J Thromb Thrombolysis. 2008 Apr;25(2):219-23 10320316 - Ultrasound Med Biol. 1999 Feb;25(2):269-73 20103314 - Ann Thorac Surg. 2010 Feb;89(2):421-7 9737524 - Circulation. 1998 Sep 8;98(10):1030-5 17255548 - Stroke. 2007 Mar;38(3):961-6 8312497 - Biophys J. 1993 Dec;65(6):2622-43 15781825 - Neurology. 2005 Mar 22;64(6):1052-4 11839413 - Ultrasound Med Biol. 2001 Dec;27(12):1683-9 10889137 - Circulation. 2000 Jul 11;102(2):238-45 19092241 - Cerebrovasc Dis. 2009;27(2):187-92 18340100 - Stroke. 2008 May;39(5):1470-5 21519235 - Blood Coagul Fibrinolysis. 2011 Jul;22(5):407-15 15548777 - N Engl J Med. 2004 Nov 18;351(21):2170-8 12751938 - J Endovasc Ther. 2003 Feb;10(1):90-8 15591211 - Stroke. 2005 Jan;36(1):124-8 16373632 - Stroke. 2006 Feb;37(2):425-9 10626631 - Ultrasound Med Biol. 1999 Nov;25(9):1431-7 17854867 - Thromb Res. 2008;121(5):663-73 10700493 - Stroke. 2000 Mar;31(3):610-4 8191404 - Thromb Haemost. 1994 Feb;71(2):230-5 19001697 - Phys Med Biol. 2008 Dec 7;53(23):6837-47 8473663 - J Am Coll Cardiol. 1993 May;21(6):1507-11 8507971 - J Card Surg. 1993 May;8(3):404-10 8085294 - Ultrasound Med Biol. 1994;20(4):375-82 RK Greenberg (469_CR22) 2000; 11 D Harpaz (469_CR18) 1993; 21 MT Wunderlich (469_CR30) 2007; 68 D Kwan (469_CR20) 2003; 10 FC Roessler (469_CR28) 2011 K Mizushige (469_CR29) 1999; 25 SB Olsson (469_CR19) 1994; 20 LH Edmunds Jr (469_CR32) 1993; 8 G Tsivgoulis (469_CR26) 2007; 38 T Holscher (469_CR13) 2009; 28 CG Lauer (469_CR15) 1992; 86 ChK Holland (469_CR11) 2008; 121 SL Diamond (469_CR25) 1993; 65 D Paparella (469_CR33) 2010; 89 J Eggers (469_CR5) 2008; 39 V Frenkel (469_CR7) 2006; 239 U Rosenschein (469_CR12) 2000; 102 A Blinc (469_CR21) 1994; 71 S Behrens (469_CR6) 1999; 25 St Pfaffenberger (469_CR10) 2005; 36 J Eggers (469_CR3) 2005; 64 V Suchkova (469_CR14) 1998; 98 AV Alexandrov (469_CR2) 2000; 31 M Nedelmann (469_CR4) 2005; 20 A Soltani (469_CR17) 2008; 53 AV Alexandrov (469_CR1) 2004; 351 K Grabska (469_CR27) 2009; 27 S Behrens (469_CR16) 2001; 27 DV Sakharov (469_CR24) 2000; 83 I Serša (469_CR23) 2007; 52 R Aaslid (469_CR31) 1986 F Perren (469_CR8) 2008; 25 CA Molina (469_CR9) 2006; 37 |
References_xml | – volume: 25 start-page: 1431 year: 1999 ident: 469_CR29 publication-title: Ultrasound in Medicine & Biology doi: 10.1016/S0301-5629(99)00095-2 contributor: fullname: K Mizushige – volume: 86 start-page: 1257 year: 1992 ident: 469_CR15 publication-title: Circulation doi: 10.1161/01.CIR.86.4.1257 contributor: fullname: CG Lauer – volume: 39 start-page: 1470 year: 2008 ident: 469_CR5 publication-title: Stroke doi: 10.1161/STROKEAHA.107.503870 contributor: fullname: J Eggers – volume: 71 start-page: 230 year: 1994 ident: 469_CR21 publication-title: Thromb Haemostasis contributor: fullname: A Blinc – volume: 31 start-page: 610 year: 2000 ident: 469_CR2 publication-title: Stroke doi: 10.1161/01.STR.31.3.610 contributor: fullname: AV Alexandrov – volume: 52 start-page: 2969 year: 2007 ident: 469_CR23 publication-title: Phys Med Biol doi: 10.1088/0031-9155/52/11/003 contributor: fullname: I Serša – volume: 102 start-page: 238 year: 2000 ident: 469_CR12 publication-title: Circulation doi: 10.1161/01.CIR.102.2.238 contributor: fullname: U Rosenschein – volume: 53 start-page: 6837 year: 2008 ident: 469_CR17 publication-title: Phys Med Biol doi: 10.1088/0031-9155/53/23/012 contributor: fullname: A Soltani – volume: 20 start-page: 18 year: 2005 ident: 469_CR4 publication-title: Cerebrovascular Diseases doi: 10.1159/000086122 contributor: fullname: M Nedelmann – volume: 25 start-page: 219 year: 2008 ident: 469_CR8 publication-title: J Thromb Thrombolysis doi: 10.1007/s11239-007-0044-6 contributor: fullname: F Perren – volume: 37 start-page: 425 year: 2006 ident: 469_CR9 publication-title: Stroke doi: 10.1161/01.STR.0000199064.94588.39 contributor: fullname: CA Molina – volume: 20 start-page: 375 year: 1994 ident: 469_CR19 publication-title: Ultrasound Med Biol doi: 10.1016/0301-5629(94)90006-X contributor: fullname: SB Olsson – volume: 10 start-page: 90 year: 2003 ident: 469_CR20 publication-title: J Endovasc Ther doi: 10.1177/152660280301000119 contributor: fullname: D Kwan – volume: 239 start-page: 86 year: 2006 ident: 469_CR7 publication-title: Radiology doi: 10.1148/radiol.2391042181 contributor: fullname: V Frenkel – volume: 8 start-page: 404 year: 1993 ident: 469_CR32 publication-title: J Card Surg doi: 10.1111/j.1540-8191.1993.tb00384.x contributor: fullname: LH Edmunds Jr – volume: 65 start-page: 2622 year: 1993 ident: 469_CR25 publication-title: Biophys J doi: 10.1016/S0006-3495(93)81314-6 contributor: fullname: SL Diamond – volume: 27 start-page: 1683 year: 2001 ident: 469_CR16 publication-title: Ultrasound in Medicine & Biology doi: 10.1016/S0301-5629(01)00481-1 contributor: fullname: S Behrens – volume: 11 start-page: 199 year: 2000 ident: 469_CR22 publication-title: J Vasc Interv Radiol doi: 10.1016/S1051-0443(07)61465-1 contributor: fullname: RK Greenberg – volume: 27 start-page: 187 year: 2009 ident: 469_CR27 publication-title: Cerebrovasc Dis doi: 10.1159/000185611 contributor: fullname: K Grabska – volume: 68 start-page: 1364 year: 2007 ident: 469_CR30 publication-title: Neurology doi: 10.1212/01.wnl.0000260604.26469.8e contributor: fullname: MT Wunderlich – volume: 98 start-page: 1030 year: 1998 ident: 469_CR14 publication-title: Circulation doi: 10.1161/01.CIR.98.10.1030 contributor: fullname: V Suchkova – volume: 83 start-page: 469 year: 2000 ident: 469_CR24 publication-title: Thromb Haemost doi: 10.1055/s-0037-1613838 contributor: fullname: DV Sakharov – volume: 28 start-page: 365 year: 2009 ident: 469_CR13 publication-title: Cerebrovasc Dis doi: 10.1159/000230710 contributor: fullname: T Holscher – volume: 351 start-page: 2170 year: 2004 ident: 469_CR1 publication-title: The New England Journal of Medicine doi: 10.1056/NEJMoa041175 contributor: fullname: AV Alexandrov – volume: 25 start-page: 269 year: 1999 ident: 469_CR6 publication-title: Ultrasound in Medicine & Biology doi: 10.1016/S0301-5629(98)00158-6 contributor: fullname: S Behrens – volume: 64 start-page: 1052 year: 2005 ident: 469_CR3 publication-title: Neurology doi: 10.1212/01.WNL.0000154599.45969.D6 contributor: fullname: J Eggers – volume: 21 start-page: 1507 year: 1993 ident: 469_CR18 publication-title: J Am Coll Cardiol doi: 10.1016/0735-1097(93)90331-T contributor: fullname: D Harpaz – volume-title: Blood Coagulation & Fibrinolysis year: 2011 ident: 469_CR28 contributor: fullname: FC Roessler – volume: 38 start-page: 961 year: 2007 ident: 469_CR26 publication-title: Stroke doi: 10.1161/01.STR.0000257314.74853.2b contributor: fullname: G Tsivgoulis – volume: 36 start-page: 124 year: 2005 ident: 469_CR10 publication-title: Stroke doi: 10.1161/01.STR.0000150503.10480.a7 contributor: fullname: St Pfaffenberger – volume-title: Transcranial Doppler sonography year: 1986 ident: 469_CR31 doi: 10.1007/978-3-7091-8864-4 contributor: fullname: R Aaslid – volume: 121 start-page: 663 year: 2008 ident: 469_CR11 publication-title: Thromb Res doi: 10.1016/j.thromres.2007.07.006 contributor: fullname: ChK Holland – volume: 89 start-page: 421 year: 2010 ident: 469_CR33 publication-title: Ann Thorac Surg doi: 10.1016/j.athoracsur.2009.10.041 contributor: fullname: D Paparella |
SSID | ssj0017841 |
Score | 1.9730631 |
Snippet | Thrombolysis is a dynamic and time-dependent process influenced by the haemodynamic conditions. Currently there is no model that allows for time-continuous,... Background Thrombolysis is a dynamic and time-dependent process influenced by the haemodynamic conditions. Currently there is no model that allows for... BACKGROUNDThrombolysis is a dynamic and time-dependent process influenced by the haemodynamic conditions. Currently there is no model that allows for... BACKGROUND: Thrombolysis is a dynamic and time-dependent process influenced by the haemodynamic conditions. Currently there is no model that allows for... Abstract Background Thrombolysis is a dynamic and time-dependent process influenced by the haemodynamic conditions. Currently there is no model that allows for... |
SourceID | doaj pubmedcentral biomedcentral proquest gale crossref pubmed |
SourceType | Open Website Open Access Repository Aggregation Database Index Database |
StartPage | 58 |
SubjectTerms | Blood Flow Velocity Care and treatment Computer Simulation Diagnosis Diagnosis, Ultrasonic Humans Hydrodynamics In Vitro Techniques Models, Biological Physiological aspects Platelet-rich plasma Reproducibility of Results Stroke (Disease) Thrombosis - pathology Thrombosis - physiopathology Time Factors |
SummonAdditionalLinks | – databaseName: BioMed Central_OA刊 dbid: RBZ link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NaxUxEB-0gngRv12tkoOgl8WXzdc-PLViqYKeLBQvIZ-4UPdJedU_ov90Z7L7XpvWm7clkw3ZnZnMTGbyC8CbkH2SaCnanI1upVeoUtKI1hmvJHfRqwnt85s-PJJfjtXxJVj0tQw-7_V7jstn2wlj6ASY6m_DnY4wzikw3_-xTRhQ-qwcJJo7zyg-_xjg2sn2k8ogFdz-m6vzFfNUl05esUUHD-D-7ESyvYnrD-FWGh_B3a9zmvwxnH-m-vM4AcOyVWaOoffMyq03DL1URjfKt1SlPoxnGPozN0Y2rsbS5MKaDZfoGyiVNMIwtn8GHJTRvQq__KogmTA6gXbKyu7IZhFl-WT1l-FAcSoGewJHB5--fzxs51sXWmSUXLdB-pL9jLFDU4VPXZ-TktEvPTbFnIWXOmRBwHQ5Gm2CQz32SsTQieSNeAo7OOP0HJhUC927qFLUUfK0cMILE4wTiXZRlG7gQ8UK-3tC2LCEeV1TUP0sMdISIzFssapv4N2GcdsXS0jT65td94mx1filAQXNzipqhUfvTEdc4kSWXOaey6R44LgGIinGBt6SWFjSfJxTcPMBBvxWwtCye4T1v-TCyAZ2q56osaEis41gWSJRmduYkNuW7iLoO4x3Gng2ydl2yh255suFasBUElh9U00Zh58FL1zwTpuFfvFff_sl3Ju206kochd21qdn6RX6Y2v_umjiBbvDNHw priority: 500 providerName: BioMedCentral – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQD4gLgvIKfcgHJLhEXcevrDgV1KogwYlKvVl-ikglqcou_Ij-aWbs7LJWD1y4RZ7EsjMznrE98w0hb3xyUYClaFPSqhVOgkoJzVurnRTMBicL2udXdXEpPl_Jq51SXxgTVuCBy4874Q5spgogeDwJJlLPRJTMM5BMIIWQV18mN5up-f4Ab9NyXpFmbce1nkF9WK9Otm2YUYaV3qtE9-vKPmUY__uL9Y61qiMpd0zT-RPyePYp6WmZy1PyII775OGX-db8Gbn7hOHooeDE0ilRS8GZprkIDgWnlWKB-RaD1odxPa1_UjsGOk5jbrJ-RYe_YBwgpNjDMLa_BuiUYpmFH27KwCYUE9JuaT4s2aypNF1Pvyl0FEps2HNyeX727eNFOxdhaIFvYtV64fJlaAgdWC546voUpQhu6aAppMSdUD5xxKlLQSvtLai1kzz4jken-QuyByOOrwgVcqF6G2QMKggWF5Y7rr22POKhilQNeV-xwtwUwA2DENg1BbTRICMNMhJ2MUb2DXm3Ydz2w7zD6dX9Vz8gY6v-cwMInpkFz_xL8BryFsXC4EIAY_J2zmeAuSKkljlF6P8l41o05LB6ExTYV2S6ESyDJIx6GyNw22Bpgr6D7U9DXhY52w65Q099uZAN0ZUEVnOqKePwPcOHc9YpvVCv_8dPOCCPyiE7hkoekr3V7ToegZe2csdZIf8APXo7FQ priority: 102 providerName: Directory of Open Access Journals – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagSIhLxZuUgnxAgktgE7-yQggVRFWQyomVerP8pJGWpN3utvAb-NPMONlurfbELfLElpN52h5_Q8grF23g4CnKGJUsuRWgUlyx0igreGW8FQPa53d5MOPfjsTRphzQ-APPblzaYT2p2WL-9vfpn4-g8B-SwjfyXQUGtqyZUnhHTDS3yZ2aM47ifsg3Rwp4wDZi-9zQKYECg3efYh277Or7PPNYCdj_uvm-4r_y3Morzmr_Ptkeo0y6N4jFA3IrdA_J3cPxHP0R-fsVE9T9gBxL-0gNhfCaprI4FMJYiiXnS0xjb7tVvzqjpvO067vUZNyStht4DhBbHKHtyvMWBqVYeOGX7RPUCcUraguatk_WVpbGeX9BYSA_ZIs9JrP9Lz8-H5RjWYYSOMmXpeM2HY96X4Mvg6e6iUFwb6cWmnyMzHLpIkPkuuiVVM6AolvBvKtZsIo9IVsw4_CMUC4msjFeBC89r8LEMMuUU4YF3GYRsiDvM1bokwGCQyModk4B_dTIU408hXWNFk1B3qwZd9kxrXkaef3VT8jYbPzU0C9-6lGHNbMQvkkPNpBFXvHYVDyIylVgJIHkfUFeo1hoFFaYkzPjDQf4VgTZ0ntYDGBaMcULspu9CSrtMjJdC5ZGEubBdQG4rbFYQVPDgqggTwc5u5zyWnwLojIJzL4pp3TtcQIUZ1Ut1UTu_HfP5-TesNeOGZO7ZGu5WIUXEKwt7cukhP8ARaVBdg priority: 102 providerName: Scholars Portal |
Title | Introduction of a new model for time-continuous and non-contact investigations of in-vitro thrombolysis under physiological flow conditions |
URI | https://www.ncbi.nlm.nih.gov/pubmed/21615905 https://search.proquest.com/docview/874482729 http://dx.doi.org/10.1186/1471-2377-11-58 https://pubmed.ncbi.nlm.nih.gov/PMC3126706 https://doaj.org/article/3b6436d8323f414f814e51c17303b6dd |
Volume | 11 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9tAEF6SFEovpe-qTc0eCu1FsaV9yfQUh4S04BBCA6aXRftqDbYUXLv9Ef3TnVlJaZbcehFiR1p2mdc-Zr4h5L0NxnPwFHkISubcCFAprlheKyN4UTsjOrTPC3l-zb8sxGKPiCEXJgbtW7M8albro2b5I8ZW3qzteIgTG1_OT1hRSjWR432yrxgbtuj91QFepPUYPkUlxwVY37xkSmECmagi-C948SnWq0tS3FeJZ4oA_vfN9B0_lcZQ3nFKZ0_I4341SY-7UT8le755Rh7O-_vy5-TPZwxEdx1CLG0DrSkso2ksf0NhuUqxtHyO4erLZtfuftK6cbRpm9hU2y1d_oPhAPHEHpZN_msJnVIssLA2bYQ0oZiKtqHxmGSwpjSs2t8UOnJdVNgLcn12-vXkPO_LL-TAMb7NLTfxGtS5EnwWvJVV8II7MzXQ5EJghksbGCLUBaeksjUotBHM2ZJ5o9hLcgAj9q8J5WIiq9oJ76TjhZ_UzDBlVc08HqcImZFPCSv0TQe1oRH8OqWAHmrkqUaewv5FiyojHwfG3f4Y9zaVvP_pDBmb9B8b2s133YuYZgaWadKBrWOBFzxUBfeisAUYQyA5l5EPKBYaTQCMydZ9JgPMFcG09DGC_k8LpnhGDpMvQXVtQqaDYGkkYbxb44HbGosSVCVsfDLyqpOz2yEP4psRlUhgMqeUAnoUgcN7vXnz33--JY-6M3WMjDwkB9vNzr-DRdnWjEAVF2pEHsxOLy6vRvFoA55zXsHzavZtFJX0L6BVQBY |
link.rule.ids | 108,230,315,733,786,790,870,891,2115,2236,24346,24965,27957,27958,31755,33780,53827,53829,76169,76170 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKkYAL70KggA9IcMnuJn5lxalUVFvoVhxa1JsVvyBiN6mWXZD4C_xpZpykNPQEt8jjWLb8zYwf428IeWmD8Rw8RRqCkik3AlSKK5aWygielc6Ilu3zWM5O-fszcbZFRP8WJgbtW1ON6sVyVFdfYmzl-dKO-zix8cf5PstyqSZyfI1cB33NVb9J7y4P8CqtY_HJCjnOwP6mOVMKn5CJItL_gh-fYsa6wSP3xcA3RQr_q4b6kqcaRlFecksHd8infkBtNMrX0WZtRvbnX1yP_zziu-R2t1Cle634Htny9X1yY95dxT8gvw4xxt215LO0CbSksEKnMbMOhZUwxaz1KUbCV_Wm2XyjZe1o3dSxqLRrWv1h-ADkYwtVnX6voFGKuRuWpolsKRRfua1oPIHpDTUNi-YHhYZcG3D2kJwevDvZn6VdZocUwMDXqeUm3rA6l4M7hK-8CF5wZ6YGilwIzHBpA0Pyu-CUVLYEW2EEczZn3ii2Q7ahx_4xoVxMZFE64Z10PPOTkhmmrCqZx5MaIRPyZjDH-rxl8dDIqz2UgIprBItGsMDWSIsiIa97RFz8GLdNhbxa9S0iZtB-LGhWn3U3l5oZWAFKB2aUBZ7xUGTci8xmYGdB5FxCXiHeNFoX6JMtu0cSMFbk6dJ7mE9gmjHFE7I7qAlWwQ7EtEesRhGG0tUeZltjvgPQmXyakEctgC-63OtFQtQA2oMxDSUA2MhJ3gH0yX__-YLcnJ3Mj_TR4fGHp-RWe3SPAZi7ZHu92vhnsPZbm-dR038DyrdcqA |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Jb9QwFLagSBUX9iVQwAckuGRmEm8ZcSqFUQu06oFKFRcr3iBiJhkNMyDxF_jTvOckZUJvvUW2Y9ny9xbbz98j5KUNxnOwFGkISqbcCBAprlhaKiN4VjojWrbPE3l4xj-ci_OtVF8xaN-aalTPF6O6-hZjK5cLO-7jxManxwcsy6WayPHShfF1cgNkNp_2G_XuAgGv0zomn6yQ4wx0cJozpfAZmSgiBTDY8ilmrRs8dJ8P7FOk8b-srLes1TCScss0zW6TL_2k2oiU76PN2ozs7__4Hq806zvkVuew0v22yV1yzdf3yO5xdyV_n_w5wlh315LQ0ibQkoKnTmOGHQoeMcXs9SlGxFf1ptn8oGXtaN3Usai0a1r9Y_oACcAeqjr9WUGnFHM4LEwTWVMovnZb0XgS0ytsGubNLwoduTbw7AE5m73_fHCYdhkeUgAFX6eWm3jT6lwOZhG-8iJ4wZ2ZGihyITDDpQ0MSfCCU1LZEnSGEczZnHmj2EOyAyP2jwnlYiKL0gnvpOOZn5TMMGVVyTye2AiZkDeDddbLls1DI7_2sAZEXSNgNAIGtkhaFAl53aPi4se4fSrk5aZvETWD_mNBs_qqu_XUzIAnKB2oUxZ4xkORcS8ym4G-hSrnEvIKMadRy8CYbNk9loC5Il-X3se8AtOMKZ6QvUFL0A52UE171GqswpC62sNqa8x7UOSwt0rIoxbEF0PuZSMhagDvwZyGNQDayE3egfTJlf98QXZP3830p6OTj0_JzfYEH-Mw98jOerXxz8AFXJvnUdj_AnUqXyg |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Introduction+of+a+new+model+for+time-continuous+and+non-contact+investigations+of+in-vitro+thrombolysis+under+physiological+flow+conditions&rft.jtitle=BMC+neurology&rft.au=Roessler%2C+Florian+C&rft.au=Ohlrich%2C+Marcus&rft.au=Marxsen%2C+Jan+H&rft.au=Schmieger%2C+Marc&rft.date=2011-05-26&rft.pub=BioMed+Central&rft.eissn=1471-2377&rft.volume=11&rft.spage=58&rft.epage=58&rft_id=info:doi/10.1186%2F1471-2377-11-58&rft_id=info%3Apmid%2F21615905&rft.externalDBID=PMC3126706 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1471-2377&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1471-2377&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1471-2377&client=summon |