Serum cytokine biomarker panels for discriminating pancreatic cancer from benign pancreatic disease

• Published in: Molecular cancer Vol. 13; no. 1; p. 114
• Main Authors: Shaw, Victoria E, Lane, Brian, Jenkinson, Claire, Cox, Trevor, Greenhalf, William, Halloran, Christopher M, Tang, Joseph, Sutton, Robert, Neoptolemos, John P, Costello, Eithne
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.05.2014; BioMed Central
• Subjects: Accuracy; Adult; Aged; Analysis; Antigens; Antigens, Tumor-Associated, Carbohydrate - blood; Antigens, Tumor-Associated, Carbohydrate - genetics; Biomarkers; Biomarkers - blood; Biomedical research; Carcinoma, Pancreatic Ductal - blood; Carcinoma, Pancreatic Ductal - diagnosis; Carcinoma, Pancreatic Ductal - genetics; Carcinoma, Pancreatic Ductal - pathology; Case-Control Studies; Cholestasis - blood; Cholestasis - diagnosis; Cholestasis - genetics; Cholestasis - pathology; Classification; Confidence intervals; Cytokines; Cytokines - blood; Cytokines - genetics; Diagnosis, Differential; Disease; Female; Gene Expression; Humans; Logistic Models; Logistics; Male; Medical research; Medicine, Experimental; Middle Aged; Pancreas; Pancreas - metabolism; Pancreas - pathology; Pancreatic cancer; Pancreatic Neoplasms - blood; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Pancreatitis, Chronic - blood; Pancreatitis, Chronic - diagnosis; Pancreatitis, Chronic - genetics; Pancreatitis, Chronic - pathology; Patients; Platelet-Derived Growth Factor - genetics; Platelet-Derived Growth Factor - metabolism

We investigated whether combinations of serum cytokines, used with logistic disease predictor models, could facilitate the detection of pancreatic ductal adenocarcinoma (PDAC). The serum levels of 27 cytokines were measured in 241 subjects, 127 with PDAC, 49 with chronic pancreatitis, 20 with benign...