Blunting type 1 insulin-like growth factor receptor expression exacerbates neuronal apoptosis following hypoxic/ischemic injury

• Published in: BMC neuroscience Vol. 12; no. 1; p. 64
• Main Authors: Liu, Wen, D'Ercole, Joseph A, Ye, Ping
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.06.2011; BioMed Central; BMC
• Subjects: Animals; Apoptosis; Diagnosis; Gene Expression; Growth factor receptors; Hypoxia-Ischemia, Brain - metabolism; Hypoxia-Ischemia, Brain - pathology; Mice; Mice, Knockout; Mice, Mutant Strains; Neurons - metabolism; Neurons - pathology; Physiological aspects; Receptor, IGF Type 1 - genetics; Receptor, IGF Type 1 - metabolism; Risk factors; Wounds and injuries; United States

Abundant experimental data have implicated an important role for insulin-like growth factor (IGF) in protecting neuronal cells from injury, including hypoxia/ischemia (H/I) injury, a major cause of neuron death. While the specific interaction of IGFs with neuronal or glial type 1 IGF receptors (IGF1...