Human Leukemia and Lymphoma Cell Lines as Models and Resources

• Published in: Current medicinal chemistry Vol. 15; no. 4; pp. 339 - 359
• Main Authors: MACLEOD, Roderick A.F., NAGEL, Stefan, SCHERR, Michaela, SCHNEIDER, Björn, DIRKS, Wilhelm G., UPHOFF, Cord C., QUENTMEIER, Hilmar, DREXLER, Hans G.
• Format: Journal Article
• Language: English
• Published: Schiphol Bentham Science Publishers Ltd 01.02.2008; Bentham Science Publishers; Bentham Science
• Subjects: Animal models; Animals; Biological and medical sciences; Cell Line, Tumor; Cell lines; cross-contamination; cytogenetics; Deoxyribonucleic acid; DNA; Drug Evaluation, Preclinical; Gene Targeting; General aspects; Humans; Leukemia; Leukemia - drug therapy; Leukemia - genetics; Leukemia - pathology; Lymphoma; Lymphoma - drug therapy; Lymphoma - genetics; Lymphoma - pathology; Medical sciences; Mycoplasma; mycoplasma oncogenes; RNA, Small Interfering - pharmacology; transcriptional profiling; Translocation, Genetic; Tumors; Chromosomal aberration; Human; transcriptional profiling; Leukemia; Malignant hemopathy; Mycoplasma; Lymphoma; Mycoplasmataceae; Mollicutes; mycoplasma oncogenes; Mycoplasmatales; Cell line; Lymphoproliferative syndrome; Cell lines; cross-contamination; Cytogenetics; Bacteria; Abnormal chromosome; Models; Onc gene; Tumor cell; Cancer; Chromosome translocation
• ISSN: 0929-8673; 1875-533X
• DOI: 10.2174/092986708783497319

Tumor cell lines are widely used as oncologic models and resources, forming, along with primary patient material and animal models, one of three major subjects for cancer investigation. With the advent of the Human Genome Project (HGP) and the ensuing provision of sequencing data and mapped clones,...