Cortisol mobilizes mineral stores from vertebral skeleton in the European eel: an ancestral origin for glucocorticoid-induced osteoporosis?

• Published in: Journal of endocrinology Vol. 201; no. 2; pp. 241 - 252
• Main Authors: Sbaihi, Miskal, Rousseau, Karine, Baloche, Sylvie, Meunier, François, Fouchereau-Peron, Martine, Dufour, Sylvie
• Format: Journal Article
• Language: English
• Published: Bristol BioScientifica 01.05.2009
• Subjects: Animals; Bioengineering; Biological and medical sciences; Biological Evolution; Biological Transport - drug effects; Bone Density - drug effects; Bone Resorption - chemically induced; Calcium - blood; Calcium - metabolism; Diseases of the osteoarticular system; Eels - blood; Eels - metabolism; Female; Glucocorticoids - adverse effects; Gonadal Steroid Hormones - pharmacology; Hydrocortisone - pharmacology; Life Sciences; Medical sciences; Minerals - metabolism; Neurobiology; Neurons and Cognition; Osteoporosis - chemically induced; Osteoporosis - metabolism; Osteoporosis. Osteomalacia. Paget disease; Phosphates - blood; Phosphates - metabolism; Regular papers; Spine - drug effects; Spine - metabolism; Vitellogenins - blood; Vitellogenins - metabolism; Corticosteroid; Demineralization; Androgen; Diseases of the osteoarticular system; Resorption; Bone disease; Minerals; Hydrocortisone; Vitellogenin; Glucocorticoid; Eel; Estradiol; Osteoporosis; Testosterone; Adrenal hormone; Skeleton; Testicular hormone; Sex steroid hormone; demineralization; histomorphometry; glucocorticoid; evolution; eel; bone resorption

Endogenous excess cortisol and glucocorticoid (GC) therapy are a major cause of secondary osteoporosis in humans. Intense bone resorption can also be observed in other vertebrates such as migratory teleost fish at the time of reproductive migration and during fasting when large amounts of calcium an...