A mathematical model of dysfunction of the thalamo-cortical loop in schizophrenia

• Published in: Theoretical biology and medical modelling Vol. 11; no. 1; p. 45
• Main Authors: Rosjat, Nils, Popovych, Svitlana, Daun-Gruhn, Silvia
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.10.2014; BioMed Central
• Subjects: Analysis; Brain research; Case-Control Studies; Cerebral Cortex - physiopathology; Dopamine; Dynamical systems; Electroencephalography; Genetic aspects; Humans; Mathematical models; Memory; Models, Theoretical; Schizophrenia; Schizophrenia - physiopathology; Thalamus - physiopathology
• ISSN: 1742-4682; 1742-4682
• DOI: 10.1186/1742-4682-11-45

Recent experimental results suggest that impairment of auditory information processing in the thalamo-cortical loop is crucially related to schizophrenia. Large differences between schizophrenia patients and healthy controls were found in the cortical EEG signals. We derive a phenomenological mathem...