Neutral evolution of protein-protein interactions: a computational study using simple models

• Published in: BMC structural biology Vol. 7; no. 1; p. 79
• Main Authors: Noirel, Josselin, Simonson, Thomas
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.11.2007; BioMed Central
• Subjects: Biochemistry, Molecular Biology; Computational Biology; Computational Biology - methods; Computer Simulation; Dimerization; Evolution, Molecular; Gene expression; Genetic aspects; Genetic Variation; Life Sciences; Models, Biological; Mutation; Mutation - genetics; Physiological aspects; Protein-protein interactions; Proteins; Proteins - genetics; Proteins - metabolism; Selection, Genetic; Structure; France
• ISSN: 1472-6807; 1472-6807
• DOI: 10.1186/1472-6807-7-79

Protein-protein interactions are central to cellular organization, and must have appeared at an early stage of evolution. To understand better their role, we consider a simple model of protein evolution and determine the effect of an explicit selection for Protein-protein interactions. In the model,...