Drug treatments for covid-19: living systematic review and network meta-analysis

• Published in: BMJ (Online) Vol. 370; p. m2980
• Main Authors: Siemieniuk, Reed AC, Bartoszko, Jessica J, Zeraatkar, Dena, Kum, Elena, Qasim, Anila, Díaz Martinez, Juan Pablo, Izcovich, Ariel, Rochwerg, Bram, Lamontagne, Francois, Han, Mi Ah, Agarwal, Arnav, Agoritsas, Thomas, Azab, Maria, Bravo, Gonzalo, Chu, Derek K, Couban, Rachel, Cusano, Ellen, Devji, Tahira, Escamilla, Zaira, Foroutan, Farid, Gao, Ya, Ge, Long, Ghadimi, Maryam, Heels-Ansdell, Diane, Honarmand, Kimia, Hou, Liangying, Ibrahim, Sara, Khamis, Assem, Lam, Bonnie, Mansilla, Cristian, Loeb, Mark, Miroshnychenko, Anna, Marcucci, Maura, McLeod, Shelley L, Motaghi, Sharhzad, Murthy, Srinivas, Mustafa, Reem A, Pardo-Hernandez, Hector, Rada, Gabriel, Rizwan, Yamna, Saadat, Pakeezah, Switzer, Charlotte, Thabane, Lehana, Tomlinson, George, Vandvik, Per O, Vernooij, Robin WM, Viteri-García, Andrés, Wang, Ying, Yao, Liang, Zhao, Yunli, Guyatt, Gordon H, Brignardello-Petersen, Romina
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 30.07.2020; BMJ Publishing Group LTD; BMJ Pub. Group; BMJ Publishing Group Ltd
• Subjects: Adenosine Monophosphate - analogs & derivatives; Adenosine Monophosphate - therapeutic use; Alanine - analogs & derivatives; Alanine - therapeutic use; Antibiotics; Antiretroviral drugs; Antiviral Agents - therapeutic use; Antiviral drugs; Asian literature; Bayesian analysis; Betacoronavirus - isolation & purification; Betacoronavirus - pathogenicity; Bias; Calibration; Centers for Disease Control and Prevention, U.S. - statistics & numerical data; China - epidemiology; Chinese literature; Clinical trials; Collaboration; Coronavirus Infections - diagnosis; Coronavirus Infections - drug therapy; Coronavirus Infections - mortality; Coronavirus Infections - therapy; Coronavirus Infections - virology; Coronaviruses; Corticosteroids; COVID-19; COVID-19 Drug Treatment; Databases, Factual - statistics & numerical data; Disease control; Drug Combinations; Drug dosages; Evidence-Based Medicine - methods; Evidence-Based Medicine - statistics & numerical data; Glucocorticoids; Glucocorticoids - therapeutic use; Humans; Hydroxychloroquine; Hydroxychloroquine - therapeutic use; Immunomodulators; Information sources; Libraries; Lopinavir; Lopinavir - therapeutic use; Mechanical ventilation; Medical research; Meta-analysis; Pandemics; Patients; Pneumonia, Viral - diagnosis; Pneumonia, Viral - mortality; Pneumonia, Viral - therapy; Pneumonia, Viral - virology; Randomized Controlled Trials as Topic; Respiration, Artificial - statistics & numerical data; Ritonavir; Ritonavir - therapeutic use; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Side effects; Standard of Care; Systematic review; Treatment Outcome; United States - epidemiology; Ventilators; United States; China

AbstractObjectiveTo compare the effects of treatments for coronavirus disease 2019 (covid-19).DesignLiving systematic review and network meta-analysis.Data sourcesWHO covid-19 database, a comprehensive multilingual source of global covid-19 literature, up to 3 December 2021 and six additional Chines...