In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

• Published in: Retrovirology Vol. 6; no. 1; p. 19
• Main Authors: Saito, Mineki, Matsuzaki, Toshio, Satou, Yorifumi, Yasunaga, Jun-ichirou, Saito, Kousuke, Arimura, Kimiyoshi, Matsuoka, Masao, Ohara, Yoshiro
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.02.2009; BioMed Central; BMC
• Subjects: Aged; Basic-Leucine Zipper Transcription Factors - genetics; Basic-Leucine Zipper Transcription Factors - immunology; Case-Control Studies; Cell Line, Tumor; Cells, Cultured; Female; Gene expression; Gene Products, tax - genetics; Gene Products, tax - immunology; Genetic aspects; HTLV-I infections; Human T-lymphotropic virus 1 - genetics; Human T-lymphotropic virus 1 - immunology; Humans; Interferon-alpha - therapeutic use; Leucine; Leukemia-Lymphoma, Adult T-Cell - drug therapy; Leukemia-Lymphoma, Adult T-Cell - immunology; Leukemia-Lymphoma, Adult T-Cell - virology; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - virology; Male; Measurement; Messenger RNA; Middle Aged; Neopterin - cerebrospinal fluid; Paraparesis, Tropical Spastic - drug therapy; Paraparesis, Tropical Spastic - immunology; Paraparesis, Tropical Spastic - virology; Retroviridae Proteins; Severity of Illness Index; Spinal Cord Diseases - drug therapy; Spinal Cord Diseases - immunology; Spinal Cord Diseases - virology; Viral Load; Viral Proteins - genetics; Viral Proteins - immunology; Viremia; Japan

Recently, human T-cell leukemia virus type 1 (HTLV-1) basic leucine zipper factor (HBZ), encoded from a minus strand mRNA was discovered and was suggested to play an important role in adult T cell leukemia (ATL) development. However, there have been no reports on the role of HBZ in patients with HTL...