Local biochemical and morphological differences in human Achilles tendinopathy: a case control study

• Published in: BMC musculoskeletal disorders Vol. 13; no. 1; p. 53
• Main Authors: J, Pingel, U, Fredberg, K, Qvortrup, J O, Larsen, P, Schjerling, K, Heinemeier, M, Kjaer, H, Langberg
• Format: Journal Article
• Language: English
• Published: England BioMed Central 05.04.2012; BioMed Central Ltd; BMC
• Subjects: Achilles Tendon - chemistry; Achilles Tendon - pathology; Achilles Tendon - ultrastructure; Biopsy; Bone surgery; Case-Control Studies; Chi-Square Distribution; Chronic Disease; Collagen; Collagenases - genetics; Denmark; Fibrillar Collagens - genetics; Fibrillar Collagens - ultrastructure; Gene expression; Gene Expression Regulation; Genetic Markers; Growth factors; Health sciences; Hospitals; Humans; Inflammation Mediators - analysis; Intercellular Signaling Peptides and Proteins - genetics; Life sciences; Microscopy, Electron, Transmission; Musculoskeletal diseases; Pain; Patients; Polymerase Chain Reaction; Rheumatology; RNA, Messenger - analysis; Studies; Tendinopathy - genetics; Tendinopathy - pathology; Tendons; Tissue Inhibitor of Metalloproteinases - genetics; Tissue turnover; Wound healing; Denmark

The incidence of Achilles tendinopathy is high and underlying etiology as well as biochemical and morphological pathology associated with the disease is largely unknown. The aim of the present study was to describe biochemical and morphological differences in chronic Achilles tendinopathy. The expre...