Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible genes in human amniotic epithelial cells

• Published in: Reproductive biology and endocrinology Vol. 4; no. 1; p. 27
• Main Authors: Abe, Yumiko, Sinozaki, Hiromitsu, Takagi, Takeshi, Minegishi, Takashi, Kokame, Koichi, Kangawa, Kenji, Uesaka, Miki, Miyamoto, Kaoru
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.05.2006; BioMed Central; BMC
• Subjects: Amnion - drug effects; Amnion - metabolism; Cells, Cultured; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Gene Expression Profiling - methods; Gene Expression Regulation - drug effects; Gene Expression Regulation - physiology; Humans; Oligonucleotide Array Sequence Analysis - methods; Polychlorinated Dibenzodioxins - pharmacology; Reverse Transcriptase Polymerase Chain Reaction - methods

Exposure to dioxins results in a broad range of pathophysiological disorders in human fetuses. In order to evaluate the effects of dioxins on the feto-placental tissues, we analyzed the gene expression in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treated primary cultures of human amniotic epithelia...