Metformin for the treatment of breast cancer: protocol for a scoping review of randomised clinical trials

• Published in: BMJ open Vol. 11; no. 8; p. e044283
• Main Authors: Araujo, Carolina Fumico Massuda, Nunes, Lélia Cápua, Murta-Nascimento, Cristiane, Souza, Cristiano de Pádua, Bragagnoli, Arinilda Campos, Fukushima, Fernanda Bono, Vidal, Edison Iglesias de Oliveira
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 09.08.2021; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Protocol
• Subjects: Antidiabetics; Bias; Breast cancer; Breast Neoplasms - drug therapy; breast tumours; Cancer therapies; Clinical trials; Delivery of Health Care; Diabetes; Disease; epidemiology; Female; Generic drugs; Humans; Medical prognosis; Metformin - therapeutic use; Oncology; Peer Review; Randomized Controlled Trials as Topic; Research Design; Scoping Reviews As Topic; Systematic review; therapeutics; Womens health; breast tumours; epidemiology; therapeutics; clinical trials; oncology

IntroductionInnovation through the repurposing of generic drugs encloses several advantages when compared with the process of developing new drugs from scratch. Metformin is an established and inexpensive antidiabetic drug for which anticancer properties have been hypothesised. A systematic review o...