Pathogenesis of ischaemic and non-ischaemic heart diseases in rheumatoid arthritis

• Published in: Rheumatic & musculoskeletal diseases open Vol. 6; no. 1; p. e001032
• Main Authors: Błyszczuk, Przemysław, Szekanecz, Zoltan
• Format: Journal Article
• Language: English
• Published: England EULAR 01.01.2020; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Review
• Subjects: Angina pectoris; Antirheumatic Agents - therapeutic use; Arthritis, Rheumatoid - drug therapy; Atherosclerosis; Blood clots; Cardiac arrhythmia; Cardiomyopathy; Cardiovascular disease; Cardiovascular system; Causality; Comorbidity; Coronary vessels; Diabetes; Disease Progression; disease-modifying antirheumatic drugs; Health risk assessment; Heart attacks; Heart failure; Heart Failure - epidemiology; Humans; Hypertension; Inflammation; Morbidity; Mortality; Myocardial Ischemia - epidemiology; Pathogenesis; Population; Rheumatoid Arthritis; Risk factors; TNF-alpha; Tumor Necrosis Factor Inhibitors - adverse effects; Tumor Necrosis Factor Inhibitors - therapeutic use; Tumor necrosis factor-TNF; cardiovascular disease; TNF-alpha; inflammation; rheumatoid arthritis; disease-modifying antirheumatic drugs

Rheumatoid arthritis (RA) is characterised by a chronic inflammatory condition of the joints, but the comorbidities of RA predominantly contribute to the reduced lifespan associated with this disease. Clinical data indicate that cardiovascular disease is the major comorbidity associated with mortali...