Pathogenesis of ischaemic and non-ischaemic heart diseases in rheumatoid arthritis
Rheumatoid arthritis (RA) is characterised by a chronic inflammatory condition of the joints, but the comorbidities of RA predominantly contribute to the reduced lifespan associated with this disease. Clinical data indicate that cardiovascular disease is the major comorbidity associated with mortali...
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| Published in | Rheumatic & musculoskeletal diseases open Vol. 6; no. 1; p. e001032 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
EULAR
01.01.2020
BMJ Publishing Group LTD BMJ Publishing Group |
| Series | Review |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Rheumatoid arthritis (RA) is characterised by a chronic inflammatory condition of the joints, but the comorbidities of RA predominantly contribute to the reduced lifespan associated with this disease. Clinical data indicate that cardiovascular disease is the major comorbidity associated with mortality in RA. In this review, we aimed to describe the pathogenesis of heart failure in RA. First, we emphasised the fundamental differences between ischaemic and non-ischaemic heart diseases and referred to their relevance in excessive cardiovascular-dependent mortality in RA. Second, we highlighted aspects of asymptomatic changes in cardiac tissue and in coronary blood vessels that are commonly found in patients with diagnosed RA. Third, we focused on high-grade systemic inflammation as a key trigger of ischaemic and non-ischaemic heart diseases in RA, and described the implication of conventional and biologic antirheumatic medications on the development and progression of heart disease. In particular, we discussed the roles of tumour necrosis factor-alpha (TNF-α) and anti-TNF-α therapies on the development and progression of ischaemic and non-ischaemic heart diseases in RA. |
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| AbstractList | Rheumatoid arthritis (RA) is characterised by a chronic inflammatory condition of the joints, but the comorbidities of RA predominantly contribute to the reduced lifespan associated with this disease. Clinical data indicate that cardiovascular disease is the major comorbidity associated with mortality in RA. In this review, we aimed to describe the pathogenesis of heart failure in RA. First, we emphasised the fundamental differences between ischaemic and non-ischaemic heart diseases and referred to their relevance in excessive cardiovascular-dependent mortality in RA. Second, we highlighted aspects of asymptomatic changes in cardiac tissue and in coronary blood vessels that are commonly found in patients with diagnosed RA. Third, we focused on high-grade systemic inflammation as a key trigger of ischaemic and non-ischaemic heart diseases in RA, and described the implication of conventional and biologic antirheumatic medications on the development and progression of heart disease. In particular, we discussed the roles of tumour necrosis factor-alpha (TNF-α) and anti-TNF-α therapies on the development and progression of ischaemic and non-ischaemic heart diseases in RA. Rheumatoid arthritis (RA) is characterised by a chronic inflammatory condition of the joints, but the comorbidities of RA predominantly contribute to the reduced lifespan associated with this disease. Clinical data indicate that cardiovascular disease is the major comorbidity associated with mortality in RA. In this review, we aimed to describe the pathogenesis of heart failure in RA. First, we emphasised the fundamental differences between ischaemic and non-ischaemic heart diseases and referred to their relevance in excessive cardiovascular-dependent mortality in RA. Second, we highlighted aspects of asymptomatic changes in cardiac tissue and in coronary blood vessels that are commonly found in patients with diagnosed RA. Third, we focused on high-grade systemic inflammation as a key trigger of ischaemic and non-ischaemic heart diseases in RA, and described the implication of conventional and biologic antirheumatic medications on the development and progression of heart disease. In particular, we discussed the roles of tumour necrosis factor-alpha (TNF-α) and anti-TNF-α therapies on the development and progression of ischaemic and non-ischaemic heart diseases in RA.Rheumatoid arthritis (RA) is characterised by a chronic inflammatory condition of the joints, but the comorbidities of RA predominantly contribute to the reduced lifespan associated with this disease. Clinical data indicate that cardiovascular disease is the major comorbidity associated with mortality in RA. In this review, we aimed to describe the pathogenesis of heart failure in RA. First, we emphasised the fundamental differences between ischaemic and non-ischaemic heart diseases and referred to their relevance in excessive cardiovascular-dependent mortality in RA. Second, we highlighted aspects of asymptomatic changes in cardiac tissue and in coronary blood vessels that are commonly found in patients with diagnosed RA. Third, we focused on high-grade systemic inflammation as a key trigger of ischaemic and non-ischaemic heart diseases in RA, and described the implication of conventional and biologic antirheumatic medications on the development and progression of heart disease. In particular, we discussed the roles of tumour necrosis factor-alpha (TNF-α) and anti-TNF-α therapies on the development and progression of ischaemic and non-ischaemic heart diseases in RA. |
| Author | Szekanecz, Zoltan Błyszczuk, Przemysław |
| AuthorAffiliation | 1 Center of Experimental Rheumatology , University of Zurich , Schlieren , Switzerland 3 Department of Rheumatology , University of Debrecen, Faculty of Medicine , Debrecen , Hungary 2 Department of Clinical Immunology , Jagiellonian University Medical College , Cracow , Poland |
| AuthorAffiliation_xml | – name: 3 Department of Rheumatology , University of Debrecen, Faculty of Medicine , Debrecen , Hungary – name: 1 Center of Experimental Rheumatology , University of Zurich , Schlieren , Switzerland – name: 2 Department of Clinical Immunology , Jagiellonian University Medical College , Cracow , Poland |
| Author_xml | – sequence: 1 givenname: Przemysław orcidid: 0000-0003-2521-3232 surname: Błyszczuk fullname: Błyszczuk, Przemysław email: przemyslaw.blyszczuk@uzh.ch organization: Department of Clinical Immunology, Jagiellonian University Medical College, Cracow, Poland – sequence: 2 givenname: Zoltan surname: Szekanecz fullname: Szekanecz, Zoltan organization: Department of Rheumatology, University of Debrecen, Faculty of Medicine, Debrecen, Hungary |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31958278$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1136/ard.2010.135871 10.1136/annrheumdis-2014-206624 10.1055/s-0037-1613033 10.1097/MD.0000000000000731 10.1002/art.24148 10.1161/01.CIR.102.25.3060 10.1161/01.CIR.0000124490.27666.B2 10.1002/art.41095 10.1186/ar2045 10.1038/nrrheum.2012.16 10.1097/RHU.0000000000000736 10.1002/art.40771 10.1186/s13075-015-0776-1 10.1002/art.23798 10.1136/annrheumdis-2016-209562 10.1016/j.ijcard.2012.05.057 10.1177/1759720X11436239 10.1007/s10067-018-4369-7 10.1002/art.22094 10.1002/art.20853 10.3899/jrheum.120621 10.3899/jrheum.180726 10.3899/jrheum.141647 10.1136/annrheumdis-2014-206411 10.1136/ard.2006.062497 10.1016/j.trsl.2010.09.005 10.1136/annrheumdis-2011-200726 10.1002/art.24092 10.1016/j.autrev.2010.07.018 10.1001/archinte.165.14.1624 10.1155/2015/342649 10.1002/art.21932 10.1093/rheumatology/kez371 10.1002/art.40841 10.1038/nrrheum.2009.219 10.1093/rheumatology/kep251 10.1002/art.21560 10.1002/acr.21861 10.1016/j.ahj.2008.02.025 10.1016/j.ijcard.2013.05.085 10.1007/s10067-009-1095-1 10.1007/s00296-018-4196-9 10.1136/annrheumdis-2016-210997 10.1186/s13075-016-1077-z 10.1136/ard.2010.143396 10.1002/art.39267 10.1136/annrheumdis-2012-202136 10.1002/art.40892 10.1177/0961203317734922 10.3899/jrheum.170770 10.1161/01.CIR.0000077913.60364.D2 10.3899/jrheum.110751 10.1136/ard.2006.059980 10.1186/ar4584 10.3899/jrheum.161184 10.1136/annrheumdis-2013-203617 10.1007/s00059-015-4320-5 10.3899/jrheum.120941 10.1371/journal.pone.0117952 10.1136/annrheumdis-2016-209775 10.1002/art.21204 10.3899/jrheum.190260 10.1161/hc3401.093154 10.1136/annrheumdis-2016-209784 10.1136/annrheumdis-2012-202442 10.1161/CIRCIMAGING.117.007495 10.1056/NEJMoa1809798 10.1016/j.semarthrit.2016.05.014 10.1016/j.semarthrit.2013.05.001 10.1016/j.jacc.2016.12.033 10.1016/j.jcmg.2014.12.025 |
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| Keywords | cardiovascular disease TNF-alpha inflammation rheumatoid arthritis disease-modifying antirheumatic drugs |
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| References | Gonzalez, Maradit Kremers, Crowson (R26) 2008; 67 Mavrogeni, Karabela, Stavropoulos (R38) 2013; 168 Galarraga, Khan, Kumar (R35) 2009; 48 Mantel, Holmqvist, Nyberg (R36) 2015; 67 Aslam, Bandeali, Khan (R10) 2013; 65 Aviña-Zubieta, Choi, Sadatsafavi (R2) 2008; 59 Cioffi, Viapiana, Ognibeni (R9) 2015; 40 Roubille, Richer, Starnino (R44) 2015; 74 Szekanecz, Kerekes, Soltész (R56) 2009; 5 McInnes, Kim, Lee (R72) 2014; 73 Goodson, Symmons, Scott (R30) 2005; 52 Lacaille, Avina-Zubieta, Sayre (R3) 2017; 76 Nicola, Crowson, Maradit-Kremers (R25) 2006; 54 Myasoedova, Crowson, Kremers (R28) 2011; 70 Ridker, Everett, Pradhan (R49) 2019; 380 Kitas, Nightingale, Armitage (R42) 2019; 71 Setoguchi, Schneeweiss, Avorn (R60) 2008; 156 Ljung, Askling, Rantapää-Dahlqvist (R62) 2014; 16 Avina-Zubieta, Thomas, Sadatsafavi (R1) 2012; 71 Jacobsson, Turesson, Nilsson (R58) 2007; 66 Harrold, Reed, Magner (R69) 2015; 17 Targońska-Stępniak, Biskup, Biskup (R41) 2019; 38 Al-Aly, Pan, Zeringue (R59) 2011; 157 Generali, Carrara, Kallikourdis (R67) 2019; 39 Suissa, Bernatsky, Hudson (R45) 2006; 55 Arts, Fransen, Den Broeder (R32) 2017; 76 Kerekes, Soltész, Dér (R68) 2009; 28 Karpouzas, Malpeso, Choi (R14) 2014; 73 Schau, Gottwald, Arbach (R39) 2015; 42 Kerekes, Soltész, Nurmohamed (R12) 2012; 8 Lindhardsen, Ahlehoff, Gislason (R19) 2011; 70 Provan, Lillegraven, Sexton (R4) 2019; 26 McCoy, Crowson, Maradit-Kremers (R21) 2013; 40 Turk, Heslinga, Dekker (R24) 2017; 44 Chauhan, Ackerman, Crowson (R23) 2015; 33 Rauchhaus, Doehner, Francis (R52) 2000; 102 Chung, Packer, Lo (R55) 2003; 107 Van Doornum, Brand, King (R22) 2006; 54 Zhao, Hong, Zhang (R64) 2015; 94 Taylor, Weinblatt, Burmester (R71) 2019; 71 Low, Symmons, Lunt (R63) 2017; 76 Ntusi, Piechnik, Francis (R6) 2015; 8 Myasoedova, Chandran, Ilhan (R31) 2016; 75 Meissner, Zink, Kekow (R37) 2016; 18 van Halm, Nurmohamed, Twisk (R50) 2006; 8 Baker, Sauer, Teng (R51) 2018; 24 Davis, Roger, Crowson (R17) 2008; 58 Escalante, Haas, del Rincón (R29) 2005; 165 Maradit-Kremers, Crowson, Nicola (R15) 2005; 52 Agca, Hopman, Laan (R20) 2019 Mantel, Holmqvist, Andersson (R16) 2017; 69 Mann, McMurray, Packer (R54) 2004; 109 Kotyla, Owczarek, Rakoczy (R61) 2012; 39 Marks, Edwards (R43) 2012; 4 Bradham, Ormseth, Elumogo (R40) 2018; 45 Tselios, Deeb, Gladman (R47) 2018; 27 Harrold, Griffith, Zueger (R65) 2019 Vázquez-Del Mercado, Nuñez-Atahualpa, Figueroa-Sánchez (R33) 2015; 2015 Espinola, Pierangeli, Gharavi (R46) 2002; 87 Rudominer, Roman, Devereux (R8) 2009; 60 Corrao, Messina, Pistone (R11) 2013; 167 Solomon, Rassen, Kuriya (R57) 2013; 72 Amigues, Tugcu, Russo (R7) 2019; 71 Agca, Heslinga, Rollefstad (R18) 2017; 76 Atzeni, Turiel, Caporali (R48) 2010; 9 Giles, Sattar, Gabriel (R66) 2019 Baghdadi, Woodman, Shanahan (R27) 2015; 10 Charles-Schoeman, Wicker, Gonzalez-Gay (R70) 2016; 46 Mavrogeni, Dimitroulas, Sfikakis (R5) 2013; 43 Semb, Rollefstad, Provan (R34) 2013; 40 Amigues, Russo, Giles (R13) 2019; 12 Sivasubramanian, Coker, Kurrelmeyer (R53) 2001; 104 Harrold, Griffith, Zueger 2019 Chung, Packer, Lo 2003; 107 Cioffi, Viapiana, Ognibeni 2015; 40 Mantel, Holmqvist, Nyberg 2015; 67 Meissner, Zink, Kekow 2016; 18 Zhao, Hong, Zhang 2015; 94 Mantel, Holmqvist, Andersson 2017; 69 Setoguchi, Schneeweiss, Avorn 2008; 156 Ntusi, Piechnik, Francis 2015; 8 Davis, Roger, Crowson 2008; 58 Jacobsson, Turesson, Nilsson 2007; 66 McInnes, Kim, Lee 2014; 73 Karpouzas, Malpeso, Choi 2014; 73 Goodson, Symmons, Scott 2005; 52 Corrao, Messina, Pistone 2013; 167 Semb, Rollefstad, Provan 2013; 40 Szekanecz, Kerekes, Soltész 2009; 5 Mann, McMurray, Packer 2004; 109 Al-Aly, Pan, Zeringue 2011; 157 Suissa, Bernatsky, Hudson 2006; 55 Kerekes, Soltész, Nurmohamed 2012; 8 Myasoedova, Crowson, Kremers 2011; 70 Provan, Lillegraven, Sexton 2019; 26 Bradham, Ormseth, Elumogo 2018; 45 Rauchhaus, Doehner, Francis 2000; 102 Espinola, Pierangeli, Gharavi 2002; 87 Kotyla, Owczarek, Rakoczy 2012; 39 Sivasubramanian, Coker, Kurrelmeyer 2001; 104 Lindhardsen, Ahlehoff, Gislason 2011; 70 Lacaille, Avina-Zubieta, Sayre 2017; 76 Agca, Hopman, Laan 2019 Ridker, Everett, Pradhan 2019; 380 Baghdadi, Woodman, Shanahan 2015; 10 Kerekes, Soltész, Dér 2009; 28 Amigues, Tugcu, Russo 2019; 71 Myasoedova, Chandran, Ilhan 2016; 75 Gonzalez, Maradit Kremers, Crowson 2008; 67 Aslam, Bandeali, Khan 2013; 65 Mavrogeni, Dimitroulas, Sfikakis 2013; 43 Atzeni, Turiel, Caporali 2010; 9 Rudominer, Roman, Devereux 2009; 60 Chauhan, Ackerman, Crowson 2015; 33 Solomon, Rassen, Kuriya 2013; 72 Harrold, Reed, Magner 2015; 17 van Halm, Nurmohamed, Twisk 2006; 8 Targońska-Stępniak, Biskup, Biskup 2019; 38 Van Doornum, Brand, King 2006; 54 Aviña-Zubieta, Choi, Sadatsafavi 2008; 59 Agca, Heslinga, Rollefstad 2017; 76 Avina-Zubieta, Thomas, Sadatsafavi 2012; 71 Nicola, Crowson, Maradit-Kremers 2006; 54 Low, Symmons, Lunt 2017; 76 Kitas, Nightingale, Armitage 2019; 71 Roubille, Richer, Starnino 2015; 74 Baker, Sauer, Teng 2018; 24 Arts, Fransen, Den Broeder 2017; 76 Ljung, Askling, Rantapää-Dahlqvist 2014; 16 Taylor, Weinblatt, Burmester 2019; 71 Charles-Schoeman, Wicker, Gonzalez-Gay 2016; 46 Galarraga, Khan, Kumar 2009; 48 Marks, Edwards 2012; 4 Tselios, Deeb, Gladman 2018; 27 Turk, Heslinga, Dekker 2017; 44 Schau, Gottwald, Arbach 2015; 42 Vázquez-Del Mercado, Nuñez-Atahualpa, Figueroa-Sánchez 2015; 2015 Giles, Sattar, Gabriel 2019 McCoy, Crowson, Maradit-Kremers 2013; 40 Mavrogeni, Karabela, Stavropoulos 2013; 168 Generali, Carrara, Kallikourdis 2019; 39 Amigues, Russo, Giles 2019; 12 Escalante, Haas, del Rincón 2005; 165 Maradit-Kremers, Crowson, Nicola 2005; 52 2025081709364593000_6.1.e001032.29 2025081709364593000_6.1.e001032.28 2025081709364593000_6.1.e001032.26 Provan (2025081709364593000_6.1.e001032.4) 2019; 26 2025081709364593000_6.1.e001032.25 2025081709364593000_6.1.e001032.69 2025081709364593000_6.1.e001032.24 2025081709364593000_6.1.e001032.68 Mantel (2025081709364593000_6.1.e001032.36) 2015; 67 2025081709364593000_6.1.e001032.22 2025081709364593000_6.1.e001032.66 2025081709364593000_6.1.e001032.21 2025081709364593000_6.1.e001032.65 2025081709364593000_6.1.e001032.20 2025081709364593000_6.1.e001032.63 2025081709364593000_6.1.e001032.62 2025081709364593000_6.1.e001032.61 Baker (2025081709364593000_6.1.e001032.51) 2018; 24 2025081709364593000_6.1.e001032.19 2025081709364593000_6.1.e001032.18 Espinola (2025081709364593000_6.1.e001032.46) 2002; 87 Charles-Schoeman (2025081709364593000_6.1.e001032.70) 2016; 46 2025081709364593000_6.1.e001032.2 2025081709364593000_6.1.e001032.17 2025081709364593000_6.1.e001032.1 2025081709364593000_6.1.e001032.16 2025081709364593000_6.1.e001032.15 2025081709364593000_6.1.e001032.59 2025081709364593000_6.1.e001032.3 2025081709364593000_6.1.e001032.14 2025081709364593000_6.1.e001032.58 2025081709364593000_6.1.e001032.57 2025081709364593000_6.1.e001032.12 2025081709364593000_6.1.e001032.56 2025081709364593000_6.1.e001032.11 2025081709364593000_6.1.e001032.55 2025081709364593000_6.1.e001032.10 2025081709364593000_6.1.e001032.54 2025081709364593000_6.1.e001032.53 2025081709364593000_6.1.e001032.52 Baghdadi (2025081709364593000_6.1.e001032.27) 2015; 10 2025081709364593000_6.1.e001032.60 Vázquez-Del Mercado (2025081709364593000_6.1.e001032.33) 2015; 2015 van Halm (2025081709364593000_6.1.e001032.50) 2006; 8 2025081709364593000_6.1.e001032.6 2025081709364593000_6.1.e001032.5 2025081709364593000_6.1.e001032.8 2025081709364593000_6.1.e001032.9 Chauhan (2025081709364593000_6.1.e001032.23) 2015; 33 2025081709364593000_6.1.e001032.49 2025081709364593000_6.1.e001032.48 2025081709364593000_6.1.e001032.45 2025081709364593000_6.1.e001032.44 2025081709364593000_6.1.e001032.43 2025081709364593000_6.1.e001032.40 Taylor (2025081709364593000_6.1.e001032.71) 2019; 71 Targońska-Stępniak (2025081709364593000_6.1.e001032.41) 2019; 38 Amigues (2025081709364593000_6.1.e001032.13) 2019; 12 2025081709364593000_6.1.e001032.39 2025081709364593000_6.1.e001032.38 2025081709364593000_6.1.e001032.37 2025081709364593000_6.1.e001032.35 2025081709364593000_6.1.e001032.34 Tselios (2025081709364593000_6.1.e001032.47) 2018; 27 2025081709364593000_6.1.e001032.32 2025081709364593000_6.1.e001032.31 2025081709364593000_6.1.e001032.30 Generali (2025081709364593000_6.1.e001032.67) 2019; 39 2025081709364593000_6.1.e001032.72 Zhao (2025081709364593000_6.1.e001032.64) 2015; 94 Amigues (2025081709364593000_6.1.e001032.7) 2019; 71 Kitas (2025081709364593000_6.1.e001032.42) 2019; 71 |
| References_xml | – volume: 70 start-page: 482 year: 2011 ident: R28 article-title: Lipid paradox in rheumatoid arthritis: the impact of serum lipid measures and systemic inflammation on the risk of cardiovascular disease publication-title: Ann Rheum Dis doi: 10.1136/ard.2010.135871 – volume: 8 start-page: 526 year: 2015 ident: R6 article-title: Diffuse myocardial fibrosis and inflammation in rheumatoid arthritis: insights from CMR T1 mapping publication-title: JACC Cardiovasc Imaging – volume: 74 start-page: 480 year: 2015 ident: R44 article-title: The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: a systematic review and meta-analysis publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2014-206624 – volume: 87 start-page: 518 year: 2002 ident: R46 article-title: Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies publication-title: Thromb Haemost doi: 10.1055/s-0037-1613033 – volume: 94 year: 2015 ident: R64 article-title: Association between anti-TNF therapy for rheumatoid arthritis and hypertension: a meta-analysis of randomized controlled trials publication-title: Medicine doi: 10.1097/MD.0000000000000731 – volume: 60 start-page: 22 year: 2009 ident: R8 article-title: Independent association of rheumatoid arthritis with increased left ventricular mass but not with reduced ejection fraction publication-title: Arthritis Rheum doi: 10.1002/art.24148 – volume: 102 start-page: 3060 year: 2000 ident: R52 article-title: Plasma cytokine parameters and mortality in patients with chronic heart failure publication-title: Circulation doi: 10.1161/01.CIR.102.25.3060 – volume: 109 start-page: 1594 year: 2004 ident: R54 article-title: Targeted anticytokine therapy in patients with chronic heart failure: results of the randomized etanercept worldwide evaluation (renewal) publication-title: Circulation doi: 10.1161/01.CIR.0000124490.27666.B2 – year: 2019 ident: R66 article-title: Cardiovascular safety of tocilizumab versus etanercept in rheumatoid arthritis: a randomized controlled trial publication-title: Arthritis Rheumatol doi: 10.1002/art.41095 – volume: 33 start-page: 84 year: 2015 ident: R23 article-title: Population-based study of QT interval prolongation in patients with rheumatoid arthritis publication-title: Clin Exp Rheumatol – volume: 8 year: 2006 ident: R50 article-title: Disease-Modifying antirheumatic drugs are associated with a reduced risk for cardiovascular disease in patients with rheumatoid arthritis: a case control study publication-title: Arthritis Res Ther doi: 10.1186/ar2045 – volume: 8 start-page: 224 year: 2012 ident: R12 article-title: Validated methods for assessment of subclinical atherosclerosis in rheumatology publication-title: Nat Rev Rheumatol doi: 10.1038/nrrheum.2012.16 – volume: 24 start-page: 203 year: 2018 ident: R51 article-title: Initiation of disease-modifying therapies in rheumatoid arthritis is associated with changes in blood pressure publication-title: J Clin Rheumatol doi: 10.1097/RHU.0000000000000736 – volume: 71 start-page: 496 year: 2019 ident: R7 article-title: Myocardial inflammation, measured using 18‐Fluorodeoxyglucose positron emission tomography with computed tomography, is associated with disease activity in rheumatoid arthritis publication-title: Arthritis Rheumatol doi: 10.1002/art.40771 – volume: 17 year: 2015 ident: R69 article-title: Comparative effectiveness and safety of rituximab versus subsequent anti-tumor necrosis factor therapy in patients with rheumatoid arthritis with prior exposure to anti-tumor necrosis factor therapies in the United States Corrona registry publication-title: Arthritis Res Ther doi: 10.1186/s13075-015-0776-1 – volume: 58 start-page: 2603 year: 2008 ident: R17 article-title: The presentation and outcome of heart failure in patients with rheumatoid arthritis differs from that in the general population publication-title: Arthritis Rheum doi: 10.1002/art.23798 – volume: 76 start-page: 1057 year: 2017 ident: R3 article-title: Improvement in 5-year mortality in incident rheumatoid arthritis compared with the general population-closing the mortality gap publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2016-209562 – volume: 167 start-page: 2031 year: 2013 ident: R11 article-title: Heart involvement in rheumatoid arthritis: systematic review and meta-analysis publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2012.05.057 – volume: 4 start-page: 149 year: 2012 ident: R43 article-title: Protective effect of methotrexate in patients with rheumatoid arthritis and cardiovascular comorbidity publication-title: Ther Adv Musculoskelet Dis doi: 10.1177/1759720X11436239 – volume: 38 start-page: 1131 year: 2019 ident: R41 article-title: Diastolic dysfunction in rheumatoid arthritis patients with low disease activity publication-title: Clin Rheumatol doi: 10.1007/s10067-018-4369-7 – volume: 55 start-page: 531 year: 2006 ident: R45 article-title: Antirheumatic drug use and the risk of acute myocardial infarction publication-title: Arthritis Rheum doi: 10.1002/art.22094 – volume: 52 start-page: 402 year: 2005 ident: R15 article-title: Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: a population-based cohort study publication-title: Arthritis Rheum doi: 10.1002/art.20853 – volume: 40 start-page: 359 year: 2013 ident: R34 article-title: Carotid plaque characteristics and disease activity in rheumatoid arthritis publication-title: J Rheumatol doi: 10.3899/jrheum.120621 – year: 2019 ident: R20 article-title: Cardiovascular event risk in rheumatoid arthritis compared with type 2 diabetes: a 15-year longitudinal study publication-title: J Rheumatol doi: 10.3899/jrheum.180726 – volume: 42 start-page: 2029 year: 2015 ident: R39 article-title: Increased prevalence of diastolic heart failure in patients with rheumatoid arthritis correlates with active disease, but not with treatment type publication-title: J Rheumatol doi: 10.3899/jrheum.141647 – volume: 75 start-page: 560 year: 2016 ident: R31 article-title: The role of rheumatoid arthritis (rA) flare and cumulative burden of RA severity in the risk of cardiovascular disease publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2014-206411 – volume: 66 start-page: 670 year: 2007 ident: R58 article-title: Treatment with TNF blockers and mortality risk in patients with rheumatoid arthritis publication-title: Ann Rheum Dis doi: 10.1136/ard.2006.062497 – volume: 157 start-page: 10 year: 2011 ident: R59 article-title: Tumor necrosis factor-α blockade, cardiovascular outcomes, and survival in rheumatoid arthritis publication-title: Transl Res doi: 10.1016/j.trsl.2010.09.005 – volume: 71 start-page: 1524 year: 2012 ident: R1 article-title: Risk of incident cardiovascular events in patients with rheumatoid arthritis: a meta-analysis of observational studies publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2011-200726 – volume: 59 start-page: 1690 year: 2008 ident: R2 article-title: Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies publication-title: Arthritis Rheum doi: 10.1002/art.24092 – volume: 9 start-page: 835 year: 2010 ident: R48 article-title: The effect of pharmacological therapy on the cardiovascular system of patients with systemic rheumatic diseases publication-title: Autoimmun Rev doi: 10.1016/j.autrev.2010.07.018 – volume: 165 start-page: 1624 year: 2005 ident: R29 article-title: Paradoxical effect of body mass index on survival in rheumatoid arthritis: role of comorbidity and systemic inflammation publication-title: Arch Intern Med doi: 10.1001/archinte.165.14.1624 – volume: 2015 start-page: 1 year: 2015 ident: R33 article-title: Serum levels of anticyclic citrullinated peptide antibodies, interlum levels of Anticyclic citrullinated peptide antibodies, interleukin-6, tumor necrosis factor- α, and C-reactive protein are associated with increased carotid intima-media thickness: a cross-sectional analysis of a cohort of rheumatoid arthritis patients without cardiovascular risk fReactive protein are associated with increased carotid intima-media thickness: a cross-sectional analysis of a cohort of rheumatoid arthritis patients without cardiovascular risk factors publication-title: Biomed Res Int doi: 10.1155/2015/342649 – volume: 54 start-page: 2061 year: 2006 ident: R22 article-title: Increased case fatality rates following a first acute cardiovascular event in patients with rheumatoid arthritis publication-title: Arthritis Rheum doi: 10.1002/art.21932 – volume: 26 year: 2019 ident: R4 article-title: Trends in all-cause and cardiovascular mortality in patients with incident rheumatoid arthritis: a 20-year follow-up matched case-cohort study publication-title: Rheumatology doi: 10.1093/rheumatology/kez371 – volume: 71 start-page: 1042 year: 2019 ident: R71 article-title: Cardiovascular safety during treatment with Baricitinib in rheumatoid arthritis publication-title: Arthritis Rheumatol doi: 10.1002/art.40841 – volume: 5 start-page: 677 year: 2009 ident: R56 article-title: Vascular effects of biologic agents in RA and spondyloarthropathies publication-title: Nat Rev Rheumatol doi: 10.1038/nrrheum.2009.219 – volume: 48 start-page: 1418 year: 2009 ident: R35 article-title: Etanercept improves inflammation-associated arterial stiffness in rheumatoid arthritis publication-title: Rheumatology doi: 10.1093/rheumatology/kep251 – volume: 54 start-page: 60 year: 2006 ident: R25 article-title: Contribution of congestive heart failure and ischemic heart disease to excess mortality in rheumatoid arthritis publication-title: Arthritis Rheum doi: 10.1002/art.21560 – volume: 65 start-page: 534 year: 2013 ident: R10 article-title: Diastolic dysfunction in rheumatoid arthritis: a meta-analysis and systematic review publication-title: Arthritis Care Res doi: 10.1002/acr.21861 – volume: 156 start-page: 336 year: 2008 ident: R60 article-title: Tumor necrosis factor-α antagonist use and heart failure in elderly patients with rheumatoid arthritis publication-title: Am Heart J doi: 10.1016/j.ahj.2008.02.025 – volume: 168 start-page: 4333 year: 2013 ident: R38 article-title: Imaging patterns of heart failure in rheumatoid arthritis evaluated by cardiovascular magnetic resonance publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2013.05.085 – volume: 28 start-page: 705 year: 2009 ident: R68 article-title: Effects of rituximab treatment on endothelial dysfunction, carotid atherosclerosis, and lipid profile in rheumatoid arthritis publication-title: Clin Rheumatol doi: 10.1007/s10067-009-1095-1 – volume: 39 start-page: 239 year: 2019 ident: R67 article-title: Risk of hospitalization for heart failure in rheumatoid arthritis patients treated with etanercept and abatacept publication-title: Rheumatol Int doi: 10.1007/s00296-018-4196-9 – volume: 76 start-page: 1693 year: 2017 ident: R32 article-title: Low disease activity (DAS28≤3.2) reduces the risk of first cardiovascular event in rheumatoid arthritis: a time-dependent COX regression analysis in a large cohort study publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2016-210997 – volume: 18 year: 2016 ident: R37 article-title: Impact of disease activity and treatment of comorbidities on the risk of myocardial infarction in rheumatoid arthritis publication-title: Arthritis Res Ther doi: 10.1186/s13075-016-1077-z – volume: 70 start-page: 929 year: 2011 ident: R19 article-title: The risk of myocardial infarction in rheumatoid arthritis and diabetes mellitus: a Danish nationwide cohort study publication-title: Ann Rheum Dis doi: 10.1136/ard.2010.143396 – volume: 67 start-page: 2845 year: 2015 ident: R36 article-title: Risk factors for the rapid increase in risk of acute coronary events in patients with new-onset rheumatoid arthritis: a nested case-control study publication-title: Arthritis Rheumatol doi: 10.1002/art.39267 – volume: 72 start-page: 1813 year: 2013 ident: R57 article-title: Heart failure risk among patients with rheumatoid arthritis starting a TNF antagonist publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2012-202136 – volume: 71 start-page: 1437 year: 2019 ident: R42 article-title: A multicenter, randomized, placebo-controlled trial of atorvastatin for the primary prevention of cardiovascular events in patients with rheumatoid arthritis publication-title: Arthritis Rheumatol doi: 10.1002/art.40892 – volume: 27 start-page: 591 year: 2018 ident: R47 article-title: Antimalarial-induced cardiomyopathy: a systematic review of the literature publication-title: Lupus doi: 10.1177/0961203317734922 – volume: 45 start-page: 1078 year: 2018 ident: R40 article-title: Absence of fibrosis and inflammation by cardiac magnetic resonance imaging in rheumatoid arthritis patients with low to moderate disease activity publication-title: J Rheumatol doi: 10.3899/jrheum.170770 – volume: 107 start-page: 3133 year: 2003 ident: R55 article-title: Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-alpha, in patients with moderate-to-severe heart failure: results of the anti-TNF therapy against congestive heart failure (attach) trial publication-title: Circulation doi: 10.1161/01.CIR.0000077913.60364.D2 – volume: 39 start-page: 701 year: 2012 ident: R61 article-title: Infliximab treatment increases left ventricular ejection fraction in patients with rheumatoid arthritis: assessment of heart function by echocardiography, endothelin 1, interleukin 6, and NT-pro brain natriuretic peptide publication-title: J Rheumatol doi: 10.3899/jrheum.110751 – volume: 67 start-page: 64 year: 2008 ident: R26 article-title: Do cardiovascular risk factors confer the same risk for cardiovascular outcomes in rheumatoid arthritis patients as in non-rheumatoid arthritis patients? publication-title: Ann Rheum Dis doi: 10.1136/ard.2006.059980 – volume: 16 year: 2014 ident: R62 article-title: The risk of acute coronary syndrome in rheumatoid arthritis in relation to tumour necrosis factor inhibitors and the risk in the general population: a national cohort study publication-title: Arthritis Res Ther doi: 10.1186/ar4584 – volume: 44 start-page: 580 year: 2017 ident: R24 article-title: The relationship between cardiac conduction times, cardiovascular risk factors, and inflammation in patients with early arthritis publication-title: J Rheumatol doi: 10.3899/jrheum.161184 – volume: 73 start-page: 1797 year: 2014 ident: R14 article-title: Prevalence, extent and composition of coronary plaque in patients with rheumatoid arthritis without symptoms or prior diagnosis of coronary artery disease publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2013-203617 – volume: 40 start-page: 989 year: 2015 ident: R9 article-title: Prevalence and factors related to left ventricular systolic dysfunction in asymptomatic patients with rheumatoid arthritis. A prospective tissue Doppler echocardiography study publication-title: Herz doi: 10.1007/s00059-015-4320-5 – volume: 40 start-page: 605 year: 2013 ident: R21 article-title: Longterm outcomes and treatment after myocardial infarction in patients with rheumatoid arthritis publication-title: J Rheumatol doi: 10.3899/jrheum.120941 – volume: 10 year: 2015 ident: R27 article-title: The impact of traditional cardiovascular risk factors on cardiovascular outcomes in patients with rheumatoid arthritis: a systematic review and meta-analysis publication-title: PLoS One doi: 10.1371/journal.pone.0117952 – volume: 76 start-page: 17 year: 2017 ident: R18 article-title: EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2016-209775 – volume: 52 start-page: 2293 year: 2005 ident: R30 article-title: Baseline levels of C-reactive protein and prediction of death from cardiovascular disease in patients with inflammatory polyarthritis: a ten-year followup study of a primary care-based inception cohort publication-title: Arthritis Rheum doi: 10.1002/art.21204 – year: 2019 ident: R65 article-title: Long-Term, real-world safety of adalimumab in rheumatoid arthritis: analysis of a prospective US-Based registry publication-title: J Rheumatol doi: 10.3899/jrheum.190260 – volume: 104 start-page: 826 year: 2001 ident: R53 article-title: Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor publication-title: Circulation doi: 10.1161/hc3401.093154 – volume: 76 start-page: 654 year: 2017 ident: R63 article-title: Relationship between exposure to tumour necrosis factor inhibitor therapy and incidence and severity of myocardial infarction in patients with rheumatoid arthritis publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2016-209784 – volume: 73 start-page: 124 year: 2014 ident: R72 article-title: Open-Label tofacitinib and double-blind atorvastatin in rheumatoid arthritis patients: a randomised study publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2012-202442 – volume: 12 year: 2019 ident: R13 article-title: Myocardial microvascular dysfunction in rheumatoid arthritisquantitation by (13)N-ammonia positron emission tomography/computed tomography publication-title: Circ Cardiovasc Imaging doi: 10.1161/CIRCIMAGING.117.007495 – volume: 380 start-page: 752 year: 2019 ident: R49 article-title: Low-Dose methotrexate for the prevention of atherosclerotic events publication-title: N Engl J Med doi: 10.1056/NEJMoa1809798 – volume: 46 start-page: 261 year: 2016 ident: R70 article-title: Cardiovascular safety findings in patients with rheumatoid arthritis treated with tofacitinib, an oral Janus kinase inhibitor publication-title: Semin Arthritis Rheum doi: 10.1016/j.semarthrit.2016.05.014 – volume: 43 start-page: 314 year: 2013 ident: R5 article-title: Heart involvement in rheumatoid arthritis: multimodality imaging and the emerging role of cardiac magnetic resonance publication-title: Semin Arthritis Rheum doi: 10.1016/j.semarthrit.2013.05.001 – volume: 69 start-page: 1275 year: 2017 ident: R16 article-title: Association between rheumatoid arthritis and risk of ischemic and nonischemic heart failure publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2016.12.033 – year: 2019 article-title: Cardiovascular event risk in rheumatoid arthritis compared with type 2 diabetes: a 15-year longitudinal study publication-title: J Rheumatol doi: 10.3899/jrheum.180726 – volume: 39 start-page: 701 year: 2012 article-title: Infliximab treatment increases left ventricular ejection fraction in patients with rheumatoid arthritis: assessment of heart function by echocardiography, endothelin 1, interleukin 6, and NT-pro brain natriuretic peptide publication-title: J Rheumatol doi: 10.3899/jrheum.110751 – volume: 104 start-page: 826 year: 2001 article-title: Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor publication-title: Circulation doi: 10.1161/hc3401.093154 – volume: 59 start-page: 1690 year: 2008 article-title: Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies publication-title: Arthritis Rheum doi: 10.1002/art.24092 – volume: 44 start-page: 580 year: 2017 article-title: The relationship between cardiac conduction times, cardiovascular risk factors, and inflammation in patients with early arthritis publication-title: J Rheumatol doi: 10.3899/jrheum.161184 – volume: 54 start-page: 60 year: 2006 article-title: Contribution of congestive heart failure and ischemic heart disease to excess mortality in rheumatoid arthritis publication-title: Arthritis Rheum doi: 10.1002/art.21560 – volume: 28 start-page: 705 year: 2009 article-title: Effects of rituximab treatment on endothelial dysfunction, carotid atherosclerosis, and lipid profile in rheumatoid arthritis publication-title: Clin Rheumatol doi: 10.1007/s10067-009-1095-1 – volume: 73 start-page: 1797 year: 2014 article-title: Prevalence, extent and composition of coronary plaque in patients with rheumatoid arthritis without symptoms or prior diagnosis of coronary artery disease publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2013-203617 – volume: 58 start-page: 2603 year: 2008 article-title: The presentation and outcome of heart failure in patients with rheumatoid arthritis differs from that in the general population publication-title: Arthritis Rheum doi: 10.1002/art.23798 – volume: 87 start-page: 518 year: 2002 article-title: Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies publication-title: Thromb Haemost doi: 10.1055/s-0037-1613033 – volume: 69 start-page: 1275 year: 2017 article-title: Association between rheumatoid arthritis and risk of ischemic and nonischemic heart failure publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2016.12.033 – volume: 74 start-page: 480 year: 2015 article-title: The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: a systematic review and meta-analysis publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2014-206624 – volume: 65 start-page: 534 year: 2013 article-title: Diastolic dysfunction in rheumatoid arthritis: a meta-analysis and systematic review publication-title: Arthritis Care Res doi: 10.1002/acr.21861 – volume: 10 year: 2015 article-title: The impact of traditional cardiovascular risk factors on cardiovascular outcomes in patients with rheumatoid arthritis: a systematic review and meta-analysis publication-title: PLoS One doi: 10.1371/journal.pone.0117952 – volume: 60 start-page: 22 year: 2009 article-title: Independent association of rheumatoid arthritis with increased left ventricular mass but not with reduced ejection fraction publication-title: Arthritis Rheum doi: 10.1002/art.24148 – volume: 12 year: 2019 article-title: Myocardial microvascular dysfunction in rheumatoid arthritisquantitation by (13)N-ammonia positron emission tomography/computed tomography publication-title: Circ Cardiovasc Imaging doi: 10.1161/CIRCIMAGING.117.007495 – volume: 48 start-page: 1418 year: 2009 article-title: Etanercept improves inflammation-associated arterial stiffness in rheumatoid arthritis publication-title: Rheumatology doi: 10.1093/rheumatology/kep251 – volume: 76 start-page: 654 year: 2017 article-title: Relationship between exposure to tumour necrosis factor inhibitor therapy and incidence and severity of myocardial infarction in patients with rheumatoid arthritis publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2016-209784 – volume: 102 start-page: 3060 year: 2000 article-title: Plasma cytokine parameters and mortality in patients with chronic heart failure publication-title: Circulation doi: 10.1161/01.CIR.102.25.3060 – volume: 27 start-page: 591 year: 2018 article-title: Antimalarial-induced cardiomyopathy: a systematic review of the literature publication-title: Lupus doi: 10.1177/0961203317734922 – volume: 70 start-page: 482 year: 2011 article-title: Lipid paradox in rheumatoid arthritis: the impact of serum lipid measures and systemic inflammation on the risk of cardiovascular disease publication-title: Ann Rheum Dis doi: 10.1136/ard.2010.135871 – volume: 40 start-page: 359 year: 2013 article-title: Carotid plaque characteristics and disease activity in rheumatoid arthritis publication-title: J Rheumatol doi: 10.3899/jrheum.120621 – volume: 2015 start-page: 1 year: 2015 article-title: Serum levels of anticyclic citrullinated peptide antibodies, interlum levels of Anticyclic citrullinated peptide antibodies, interleukin-6, tumor necrosis factor- α, and C-reactive protein are associated with increased carotid intima-media thickness: a cross-sectional analysis of a cohort of rheumatoid arthritis patients without cardiovascular risk fReactive protein are associated with increased carotid intima-media thickness: a cross-sectional analysis of a cohort of rheumatoid arthritis patients without cardiovascular risk factors publication-title: Biomed Res Int doi: 10.1155/2015/342649 – volume: 66 start-page: 670 year: 2007 article-title: Treatment with TNF blockers and mortality risk in patients with rheumatoid arthritis publication-title: Ann Rheum Dis doi: 10.1136/ard.2006.062497 – volume: 71 start-page: 1524 year: 2012 article-title: Risk of incident cardiovascular events in patients with rheumatoid arthritis: a meta-analysis of observational studies publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2011-200726 – volume: 38 start-page: 1131 year: 2019 article-title: Diastolic dysfunction in rheumatoid arthritis patients with low disease activity publication-title: Clin Rheumatol doi: 10.1007/s10067-018-4369-7 – volume: 52 start-page: 2293 year: 2005 article-title: Baseline levels of C-reactive protein and prediction of death from cardiovascular disease in patients with inflammatory polyarthritis: a ten-year followup study of a primary care-based inception cohort publication-title: Arthritis Rheum doi: 10.1002/art.21204 – volume: 40 start-page: 989 year: 2015 article-title: Prevalence and factors related to left ventricular systolic dysfunction in asymptomatic patients with rheumatoid arthritis. A prospective tissue Doppler echocardiography study publication-title: Herz doi: 10.1007/s00059-015-4320-5 – volume: 45 start-page: 1078 year: 2018 article-title: Absence of fibrosis and inflammation by cardiac magnetic resonance imaging in rheumatoid arthritis patients with low to moderate disease activity publication-title: J Rheumatol doi: 10.3899/jrheum.170770 – volume: 165 start-page: 1624 year: 2005 article-title: Paradoxical effect of body mass index on survival in rheumatoid arthritis: role of comorbidity and systemic inflammation publication-title: Arch Intern Med doi: 10.1001/archinte.165.14.1624 – volume: 94 year: 2015 article-title: Association between anti-TNF therapy for rheumatoid arthritis and hypertension: a meta-analysis of randomized controlled trials publication-title: Medicine doi: 10.1097/MD.0000000000000731 – volume: 168 start-page: 4333 year: 2013 article-title: Imaging patterns of heart failure in rheumatoid arthritis evaluated by cardiovascular magnetic resonance publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2013.05.085 – volume: 5 start-page: 677 year: 2009 article-title: Vascular effects of biologic agents in RA and spondyloarthropathies publication-title: Nat Rev Rheumatol doi: 10.1038/nrrheum.2009.219 – volume: 39 start-page: 239 year: 2019 article-title: Risk of hospitalization for heart failure in rheumatoid arthritis patients treated with etanercept and abatacept publication-title: Rheumatol Int doi: 10.1007/s00296-018-4196-9 – volume: 18 year: 2016 article-title: Impact of disease activity and treatment of comorbidities on the risk of myocardial infarction in rheumatoid arthritis publication-title: Arthritis Res Ther doi: 10.1186/s13075-016-1077-z – volume: 17 year: 2015 article-title: Comparative effectiveness and safety of rituximab versus subsequent anti-tumor necrosis factor therapy in patients with rheumatoid arthritis with prior exposure to anti-tumor necrosis factor therapies in the United States Corrona registry publication-title: Arthritis Res Ther doi: 10.1186/s13075-015-0776-1 – volume: 43 start-page: 314 year: 2013 article-title: Heart involvement in rheumatoid arthritis: multimodality imaging and the emerging role of cardiac magnetic resonance publication-title: Semin Arthritis Rheum doi: 10.1016/j.semarthrit.2013.05.001 – volume: 107 start-page: 3133 year: 2003 article-title: Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-alpha, in patients with moderate-to-severe heart failure: results of the anti-TNF therapy against congestive heart failure (attach) trial publication-title: Circulation doi: 10.1161/01.CIR.0000077913.60364.D2 – volume: 54 start-page: 2061 year: 2006 article-title: Increased case fatality rates following a first acute cardiovascular event in patients with rheumatoid arthritis publication-title: Arthritis Rheum doi: 10.1002/art.21932 – volume: 71 start-page: 1437 year: 2019 article-title: A multicenter, randomized, placebo-controlled trial of atorvastatin for the primary prevention of cardiovascular events in patients with rheumatoid arthritis publication-title: Arthritis Rheumatol doi: 10.1002/art.40892 – volume: 46 start-page: 261 year: 2016 article-title: Cardiovascular safety findings in patients with rheumatoid arthritis treated with tofacitinib, an oral Janus kinase inhibitor publication-title: Semin Arthritis Rheum doi: 10.1016/j.semarthrit.2016.05.014 – volume: 26 year: 2019 article-title: Trends in all-cause and cardiovascular mortality in patients with incident rheumatoid arthritis: a 20-year follow-up matched case-cohort study publication-title: Rheumatology doi: 10.1093/rheumatology/kez371 – volume: 42 start-page: 2029 year: 2015 article-title: Increased prevalence of diastolic heart failure in patients with rheumatoid arthritis correlates with active disease, but not with treatment type publication-title: J Rheumatol doi: 10.3899/jrheum.141647 – volume: 76 start-page: 1057 year: 2017 article-title: Improvement in 5-year mortality in incident rheumatoid arthritis compared with the general population-closing the mortality gap publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2016-209562 – volume: 75 start-page: 560 year: 2016 article-title: The role of rheumatoid arthritis (rA) flare and cumulative burden of RA severity in the risk of cardiovascular disease publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2014-206411 – volume: 67 start-page: 2845 year: 2015 article-title: Risk factors for the rapid increase in risk of acute coronary events in patients with new-onset rheumatoid arthritis: a nested case-control study publication-title: Arthritis Rheumatol doi: 10.1002/art.39267 – volume: 8 year: 2006 article-title: Disease-Modifying antirheumatic drugs are associated with a reduced risk for cardiovascular disease in patients with rheumatoid arthritis: a case control study publication-title: Arthritis Res Ther doi: 10.1186/ar2045 – volume: 157 start-page: 10 year: 2011 article-title: Tumor necrosis factor-α blockade, cardiovascular outcomes, and survival in rheumatoid arthritis publication-title: Transl Res doi: 10.1016/j.trsl.2010.09.005 – volume: 8 start-page: 526 year: 2015 article-title: Diffuse myocardial fibrosis and inflammation in rheumatoid arthritis: insights from CMR T1 mapping publication-title: JACC Cardiovasc Imaging – volume: 72 start-page: 1813 year: 2013 article-title: Heart failure risk among patients with rheumatoid arthritis starting a TNF antagonist publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2012-202136 – volume: 67 start-page: 64 year: 2008 article-title: Do cardiovascular risk factors confer the same risk for cardiovascular outcomes in rheumatoid arthritis patients as in non-rheumatoid arthritis patients? publication-title: Ann Rheum Dis doi: 10.1136/ard.2006.059980 – volume: 70 start-page: 929 year: 2011 article-title: The risk of myocardial infarction in rheumatoid arthritis and diabetes mellitus: a Danish nationwide cohort study publication-title: Ann Rheum Dis doi: 10.1136/ard.2010.143396 – volume: 167 start-page: 2031 year: 2013 article-title: Heart involvement in rheumatoid arthritis: systematic review and meta-analysis publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2012.05.057 – volume: 73 start-page: 124 year: 2014 article-title: Open-Label tofacitinib and double-blind atorvastatin in rheumatoid arthritis patients: a randomised study publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2012-202442 – volume: 4 start-page: 149 year: 2012 article-title: Protective effect of methotrexate in patients with rheumatoid arthritis and cardiovascular comorbidity publication-title: Ther Adv Musculoskelet Dis doi: 10.1177/1759720X11436239 – volume: 109 start-page: 1594 year: 2004 article-title: Targeted anticytokine therapy in patients with chronic heart failure: results of the randomized etanercept worldwide evaluation (renewal) publication-title: Circulation doi: 10.1161/01.CIR.0000124490.27666.B2 – volume: 52 start-page: 402 year: 2005 article-title: Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: a population-based cohort study publication-title: Arthritis Rheum doi: 10.1002/art.20853 – volume: 16 year: 2014 article-title: The risk of acute coronary syndrome in rheumatoid arthritis in relation to tumour necrosis factor inhibitors and the risk in the general population: a national cohort study publication-title: Arthritis Res Ther doi: 10.1186/ar4584 – volume: 55 start-page: 531 year: 2006 article-title: Antirheumatic drug use and the risk of acute myocardial infarction publication-title: Arthritis Rheum doi: 10.1002/art.22094 – volume: 33 start-page: 84 year: 2015 article-title: Population-based study of QT interval prolongation in patients with rheumatoid arthritis publication-title: Clin Exp Rheumatol – year: 2019 article-title: Long-Term, real-world safety of adalimumab in rheumatoid arthritis: analysis of a prospective US-Based registry publication-title: J Rheumatol doi: 10.3899/jrheum.190260 – volume: 8 start-page: 224 year: 2012 article-title: Validated methods for assessment of subclinical atherosclerosis in rheumatology publication-title: Nat Rev Rheumatol doi: 10.1038/nrrheum.2012.16 – volume: 156 start-page: 336 year: 2008 article-title: Tumor necrosis factor-α antagonist use and heart failure in elderly patients with rheumatoid arthritis publication-title: Am Heart J doi: 10.1016/j.ahj.2008.02.025 – volume: 71 start-page: 1042 year: 2019 article-title: Cardiovascular safety during treatment with Baricitinib in rheumatoid arthritis publication-title: Arthritis Rheumatol doi: 10.1002/art.40841 – volume: 71 start-page: 496 year: 2019 article-title: Myocardial inflammation, measured using 18‐Fluorodeoxyglucose positron emission tomography with computed tomography, is associated with disease activity in rheumatoid arthritis publication-title: Arthritis Rheumatol doi: 10.1002/art.40771 – volume: 40 start-page: 605 year: 2013 article-title: Longterm outcomes and treatment after myocardial infarction in patients with rheumatoid arthritis publication-title: J Rheumatol doi: 10.3899/jrheum.120941 – volume: 9 start-page: 835 year: 2010 article-title: The effect of pharmacological therapy on the cardiovascular system of patients with systemic rheumatic diseases publication-title: Autoimmun Rev doi: 10.1016/j.autrev.2010.07.018 – year: 2019 article-title: Cardiovascular safety of tocilizumab versus etanercept in rheumatoid arthritis: a randomized controlled trial publication-title: Arthritis Rheumatol doi: 10.1002/art.41095 – volume: 76 start-page: 17 year: 2017 article-title: EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2016-209775 – volume: 76 start-page: 1693 year: 2017 article-title: Low disease activity (DAS28≤3.2) reduces the risk of first cardiovascular event in rheumatoid arthritis: a time-dependent COX regression analysis in a large cohort study publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2016-210997 – volume: 380 start-page: 752 year: 2019 article-title: Low-Dose methotrexate for the prevention of atherosclerotic events publication-title: N Engl J Med doi: 10.1056/NEJMoa1809798 – volume: 24 start-page: 203 year: 2018 article-title: Initiation of disease-modifying therapies in rheumatoid arthritis is associated with changes in blood pressure publication-title: J Clin Rheumatol doi: 10.1097/RHU.0000000000000736 – ident: 2025081709364593000_6.1.e001032.10 doi: 10.1002/acr.21861 – ident: 2025081709364593000_6.1.e001032.48 doi: 10.1016/j.autrev.2010.07.018 – ident: 2025081709364593000_6.1.e001032.58 doi: 10.1136/ard.2006.062497 – volume: 10 year: 2015 ident: 2025081709364593000_6.1.e001032.27 article-title: The impact of traditional cardiovascular risk factors on cardiovascular outcomes in patients with rheumatoid arthritis: a systematic review and meta-analysis publication-title: PLoS One doi: 10.1371/journal.pone.0117952 – ident: 2025081709364593000_6.1.e001032.9 doi: 10.1007/s00059-015-4320-5 – ident: 2025081709364593000_6.1.e001032.20 doi: 10.3899/jrheum.180726 – volume: 33 start-page: 84 year: 2015 ident: 2025081709364593000_6.1.e001032.23 article-title: Population-based study of QT interval prolongation in patients with rheumatoid arthritis publication-title: Clin Exp Rheumatol – ident: 2025081709364593000_6.1.e001032.44 doi: 10.1136/annrheumdis-2014-206624 – ident: 2025081709364593000_6.1.e001032.24 doi: 10.3899/jrheum.161184 – volume: 71 start-page: 1042 year: 2019 ident: 2025081709364593000_6.1.e001032.71 article-title: Cardiovascular safety during treatment with Baricitinib in rheumatoid arthritis publication-title: Arthritis Rheumatol doi: 10.1002/art.40841 – ident: 2025081709364593000_6.1.e001032.25 doi: 10.1002/art.21560 – volume: 71 start-page: 1437 year: 2019 ident: 2025081709364593000_6.1.e001032.42 article-title: A multicenter, randomized, placebo-controlled trial of atorvastatin for the primary prevention of cardiovascular events in patients with rheumatoid arthritis publication-title: Arthritis Rheumatol doi: 10.1002/art.40892 – ident: 2025081709364593000_6.1.e001032.57 doi: 10.1136/annrheumdis-2012-202136 – ident: 2025081709364593000_6.1.e001032.69 doi: 10.1186/s13075-015-0776-1 – ident: 2025081709364593000_6.1.e001032.43 doi: 10.1177/1759720X11436239 – ident: 2025081709364593000_6.1.e001032.65 doi: 10.3899/jrheum.190260 – ident: 2025081709364593000_6.1.e001032.62 doi: 10.1186/ar4584 – ident: 2025081709364593000_6.1.e001032.61 doi: 10.3899/jrheum.110751 – ident: 2025081709364593000_6.1.e001032.30 doi: 10.1002/art.21204 – ident: 2025081709364593000_6.1.e001032.49 doi: 10.1056/NEJMoa1809798 – ident: 2025081709364593000_6.1.e001032.63 doi: 10.1136/annrheumdis-2016-209784 – ident: 2025081709364593000_6.1.e001032.21 doi: 10.3899/jrheum.120941 – ident: 2025081709364593000_6.1.e001032.40 doi: 10.3899/jrheum.170770 – ident: 2025081709364593000_6.1.e001032.8 doi: 10.1002/art.24148 – ident: 2025081709364593000_6.1.e001032.17 doi: 10.1002/art.23798 – ident: 2025081709364593000_6.1.e001032.14 doi: 10.1136/annrheumdis-2013-203617 – ident: 2025081709364593000_6.1.e001032.34 doi: 10.3899/jrheum.120621 – ident: 2025081709364593000_6.1.e001032.1 doi: 10.1136/annrheumdis-2011-200726 – volume: 2015 start-page: 1 year: 2015 ident: 2025081709364593000_6.1.e001032.33 article-title: Serum levels of anticyclic citrullinated peptide antibodies, interlum levels of Anticyclic citrullinated peptide antibodies, interleukin-6, tumor necrosis factor- α, and C-reactive protein are associated with increased carotid intima-media thickness: a cross-sectional analysis of a cohort of rheumatoid arthritis patients without cardiovascular risk fReactive protein are associated with increased carotid intima-media thickness: a cross-sectional analysis of a cohort of rheumatoid arthritis patients without cardiovascular risk factors publication-title: Biomed Res Int – ident: 2025081709364593000_6.1.e001032.59 doi: 10.1016/j.trsl.2010.09.005 – volume: 94 year: 2015 ident: 2025081709364593000_6.1.e001032.64 article-title: Association between anti-TNF therapy for rheumatoid arthritis and hypertension: a meta-analysis of randomized controlled trials publication-title: Medicine doi: 10.1097/MD.0000000000000731 – ident: 2025081709364593000_6.1.e001032.56 doi: 10.1038/nrrheum.2009.219 – ident: 2025081709364593000_6.1.e001032.6 doi: 10.1016/j.jcmg.2014.12.025 – ident: 2025081709364593000_6.1.e001032.16 doi: 10.1016/j.jacc.2016.12.033 – ident: 2025081709364593000_6.1.e001032.35 doi: 10.1093/rheumatology/kep251 – ident: 2025081709364593000_6.1.e001032.37 doi: 10.1186/s13075-016-1077-z – volume: 87 start-page: 518 year: 2002 ident: 2025081709364593000_6.1.e001032.46 article-title: Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies publication-title: Thromb Haemost doi: 10.1055/s-0037-1613033 – ident: 2025081709364593000_6.1.e001032.15 doi: 10.1002/art.20853 – ident: 2025081709364593000_6.1.e001032.2 doi: 10.1002/art.24092 – ident: 2025081709364593000_6.1.e001032.55 doi: 10.1161/01.CIR.0000077913.60364.D2 – ident: 2025081709364593000_6.1.e001032.5 doi: 10.1016/j.semarthrit.2013.05.001 – ident: 2025081709364593000_6.1.e001032.53 doi: 10.1161/hc3401.093154 – ident: 2025081709364593000_6.1.e001032.54 doi: 10.1161/01.CIR.0000124490.27666.B2 – volume: 26 year: 2019 ident: 2025081709364593000_6.1.e001032.4 article-title: Trends in all-cause and cardiovascular mortality in patients with incident rheumatoid arthritis: a 20-year follow-up matched case-cohort study publication-title: Rheumatology doi: 10.1093/rheumatology/kez371 – ident: 2025081709364593000_6.1.e001032.60 doi: 10.1016/j.ahj.2008.02.025 – ident: 2025081709364593000_6.1.e001032.22 doi: 10.1002/art.21932 – ident: 2025081709364593000_6.1.e001032.26 doi: 10.1136/ard.2006.059980 – ident: 2025081709364593000_6.1.e001032.72 doi: 10.1136/annrheumdis-2012-202442 – volume: 8 year: 2006 ident: 2025081709364593000_6.1.e001032.50 article-title: Disease-Modifying antirheumatic drugs are associated with a reduced risk for cardiovascular disease in patients with rheumatoid arthritis: a case control study publication-title: Arthritis Res Ther doi: 10.1186/ar2045 – volume: 24 start-page: 203 year: 2018 ident: 2025081709364593000_6.1.e001032.51 article-title: Initiation of disease-modifying therapies in rheumatoid arthritis is associated with changes in blood pressure publication-title: J Clin Rheumatol doi: 10.1097/RHU.0000000000000736 – volume: 71 start-page: 496 year: 2019 ident: 2025081709364593000_6.1.e001032.7 article-title: Myocardial inflammation, measured using 18‐Fluorodeoxyglucose positron emission tomography with computed tomography, is associated with disease activity in rheumatoid arthritis publication-title: Arthritis Rheumatol doi: 10.1002/art.40771 – ident: 2025081709364593000_6.1.e001032.19 doi: 10.1136/ard.2010.143396 – volume: 39 start-page: 239 year: 2019 ident: 2025081709364593000_6.1.e001032.67 article-title: Risk of hospitalization for heart failure in rheumatoid arthritis patients treated with etanercept and abatacept publication-title: Rheumatol Int doi: 10.1007/s00296-018-4196-9 – ident: 2025081709364593000_6.1.e001032.18 doi: 10.1136/annrheumdis-2016-209775 – volume: 46 start-page: 261 year: 2016 ident: 2025081709364593000_6.1.e001032.70 article-title: Cardiovascular safety findings in patients with rheumatoid arthritis treated with tofacitinib, an oral Janus kinase inhibitor publication-title: Semin Arthritis Rheum doi: 10.1016/j.semarthrit.2016.05.014 – ident: 2025081709364593000_6.1.e001032.31 doi: 10.1136/annrheumdis-2014-206411 – ident: 2025081709364593000_6.1.e001032.38 doi: 10.1016/j.ijcard.2013.05.085 – ident: 2025081709364593000_6.1.e001032.66 doi: 10.1002/art.41095 – ident: 2025081709364593000_6.1.e001032.11 doi: 10.1016/j.ijcard.2012.05.057 – ident: 2025081709364593000_6.1.e001032.52 doi: 10.1161/01.CIR.102.25.3060 – ident: 2025081709364593000_6.1.e001032.45 doi: 10.1002/art.22094 – ident: 2025081709364593000_6.1.e001032.28 doi: 10.1136/ard.2010.135871 – volume: 12 year: 2019 ident: 2025081709364593000_6.1.e001032.13 article-title: Myocardial microvascular dysfunction in rheumatoid arthritisquantitation by (13)N-ammonia positron emission tomography/computed tomography publication-title: Circ Cardiovasc Imaging doi: 10.1161/CIRCIMAGING.117.007495 – volume: 38 start-page: 1131 year: 2019 ident: 2025081709364593000_6.1.e001032.41 article-title: Diastolic dysfunction in rheumatoid arthritis patients with low disease activity publication-title: Clin Rheumatol doi: 10.1007/s10067-018-4369-7 – ident: 2025081709364593000_6.1.e001032.32 doi: 10.1136/annrheumdis-2016-210997 – ident: 2025081709364593000_6.1.e001032.68 doi: 10.1007/s10067-009-1095-1 – ident: 2025081709364593000_6.1.e001032.29 doi: 10.1001/archinte.165.14.1624 – ident: 2025081709364593000_6.1.e001032.12 doi: 10.1038/nrrheum.2012.16 – ident: 2025081709364593000_6.1.e001032.3 doi: 10.1136/annrheumdis-2016-209562 – ident: 2025081709364593000_6.1.e001032.39 doi: 10.3899/jrheum.141647 – volume: 27 start-page: 591 year: 2018 ident: 2025081709364593000_6.1.e001032.47 article-title: Antimalarial-induced cardiomyopathy: a systematic review of the literature publication-title: Lupus doi: 10.1177/0961203317734922 – volume: 67 start-page: 2845 year: 2015 ident: 2025081709364593000_6.1.e001032.36 article-title: Risk factors for the rapid increase in risk of acute coronary events in patients with new-onset rheumatoid arthritis: a nested case-control study publication-title: Arthritis Rheumatol doi: 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| Snippet | Rheumatoid arthritis (RA) is characterised by a chronic inflammatory condition of the joints, but the comorbidities of RA predominantly contribute to the... |
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| SubjectTerms | Angina pectoris Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - drug therapy Atherosclerosis Blood clots Cardiac arrhythmia Cardiomyopathy Cardiovascular disease Cardiovascular system Causality Comorbidity Coronary vessels Diabetes Disease Progression disease-modifying antirheumatic drugs Health risk assessment Heart attacks Heart failure Heart Failure - epidemiology Humans Hypertension Inflammation Morbidity Mortality Myocardial Ischemia - epidemiology Pathogenesis Population Rheumatoid Arthritis Risk factors TNF-alpha Tumor Necrosis Factor Inhibitors - adverse effects Tumor Necrosis Factor Inhibitors - therapeutic use Tumor necrosis factor-TNF |
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| Title | Pathogenesis of ischaemic and non-ischaemic heart diseases in rheumatoid arthritis |
| URI | https://rmdopen.bmj.com/content/6/1/e001032.full https://www.ncbi.nlm.nih.gov/pubmed/31958278 https://www.proquest.com/docview/2347569619 https://www.proquest.com/docview/2343040452 https://pubmed.ncbi.nlm.nih.gov/PMC7046979 https://doaj.org/article/74da920615e848d089dfb6c7ab829ec0 |
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