Probiotic supplements and bone health in postmenopausal women: a meta-analysis of randomised controlled trials

ObjectiveOsteoporosis is a common disease in postmenopausal women. Several studies have analysed the associations between dietary supplementation with probiotics and bone health in postmenopausal women, but the results are still controversial. We conducted this meta-analysis to assess the effects of...

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Published inBMJ open Vol. 11; no. 3; p. e041393
Main Authors Yu, Jiawei, Cao, Gaoyang, Yuan, Shuohui, Luo, Cong, Yu, Jiafeng, Cai, Ming
Format Journal Article
LanguageEnglish
Published England British Medical Journal Publishing Group 02.03.2021
BMJ Publishing Group LTD
BMJ Publishing Group
SeriesOriginal research
Subjects
Bias
Bone Density
bone diseases
Dietary Supplements
Evidence Based Practice
Female
hip
Humans
Meta-analysis
nutrition & dietetics
Osteoporosis
Osteoporosis, Postmenopausal - prevention & control
Patients
Phosphatase
Postmenopause
Probiotics
Randomized Controlled Trials as Topic
spine
Systematic review
Tumor necrosis factor-TNF
Womens health
Denmark
Sweden
Japan
bone diseases
spine
nutrition & dietetics
hip
Online AccessGet full text

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Abstract ObjectiveOsteoporosis is a common disease in postmenopausal women. Several studies have analysed the associations between dietary supplementation with probiotics and bone health in postmenopausal women, but the results are still controversial. We conducted this meta-analysis to assess the effects of probiotics supplement on bone mineral density (BMD) and bone turnover markers for postmenopausal women.DesignSystematic review and meta-analysis.MethodsWe systematically searched PubMed, EMBASE and the Cochrane Library from their inception to November 2020 for randomised controlled trials (RCTs) assessing probiotic supplements and osteoporosis in postmenopausal women. Study-specific risk estimates were combined using random-effect models.ResultsFive RCTs (n=497) were included. Probiotic supplements were associated with a significantly higher BMD in the lumbar spine (standardised mean difference, SMD=0.27, 95% CI 0.09 to 0.44) than in control. There was no difference between probiotic supplements and BMD in hips (SMD=0.22, 95% CI −0.07 to 0.52). Collagen type 1 cross-linked C-telopeptide levels in the treatment groups were significantly lower than those of the placebo group (SMD=−0.34, 95% CI −0.60 to −0.09). In subgroup meta-analysis, levels of bone-specific alkaline phosphatase, osteoprotegerin, osteocalcin and tumour necrosis factor did not differ between the probiotic and placebo groups.ConclusionsWe conclude cautiously that supplementation with probiotics could increase lumbar BMD. More RCTs are recommended to validate or update these results.
AbstractList Osteoporosis is a common disease in postmenopausal women. Several studies have analysed the associations between dietary supplementation with probiotics and bone health in postmenopausal women, but the results are still controversial. We conducted this meta-analysis to assess the effects of probiotics supplement on bone mineral density (BMD) and bone turnover markers for postmenopausal women.OBJECTIVEOsteoporosis is a common disease in postmenopausal women. Several studies have analysed the associations between dietary supplementation with probiotics and bone health in postmenopausal women, but the results are still controversial. We conducted this meta-analysis to assess the effects of probiotics supplement on bone mineral density (BMD) and bone turnover markers for postmenopausal women.Systematic review and meta-analysis.DESIGNSystematic review and meta-analysis.We systematically searched PubMed, EMBASE and the Cochrane Library from their inception to November 2020 for randomised controlled trials (RCTs) assessing probiotic supplements and osteoporosis in postmenopausal women. Study-specific risk estimates were combined using random-effect models.METHODSWe systematically searched PubMed, EMBASE and the Cochrane Library from their inception to November 2020 for randomised controlled trials (RCTs) assessing probiotic supplements and osteoporosis in postmenopausal women. Study-specific risk estimates were combined using random-effect models.Five RCTs (n=497) were included. Probiotic supplements were associated with a significantly higher BMD in the lumbar spine (standardised mean difference, SMD=0.27, 95% CI 0.09 to 0.44) than in control. There was no difference between probiotic supplements and BMD in hips (SMD=0.22, 95% CI -0.07 to 0.52). Collagen type 1 cross-linked C-telopeptide levels in the treatment groups were significantly lower than those of the placebo group (SMD=-0.34, 95% CI -0.60 to -0.09). In subgroup meta-analysis, levels of bone-specific alkaline phosphatase, osteoprotegerin, osteocalcin and tumour necrosis factor did not differ between the probiotic and placebo groups.RESULTSFive RCTs (n=497) were included. Probiotic supplements were associated with a significantly higher BMD in the lumbar spine (standardised mean difference, SMD=0.27, 95% CI 0.09 to 0.44) than in control. There was no difference between probiotic supplements and BMD in hips (SMD=0.22, 95% CI -0.07 to 0.52). Collagen type 1 cross-linked C-telopeptide levels in the treatment groups were significantly lower than those of the placebo group (SMD=-0.34, 95% CI -0.60 to -0.09). In subgroup meta-analysis, levels of bone-specific alkaline phosphatase, osteoprotegerin, osteocalcin and tumour necrosis factor did not differ between the probiotic and placebo groups.We conclude cautiously that supplementation with probiotics could increase lumbar BMD. More RCTs are recommended to validate or update these results.CONCLUSIONSWe conclude cautiously that supplementation with probiotics could increase lumbar BMD. More RCTs are recommended to validate or update these results.
Osteoporosis is a common disease in postmenopausal women. Several studies have analysed the associations between dietary supplementation with probiotics and bone health in postmenopausal women, but the results are still controversial. We conducted this meta-analysis to assess the effects of probiotics supplement on bone mineral density (BMD) and bone turnover markers for postmenopausal women. Systematic review and meta-analysis. We systematically searched PubMed, EMBASE and the Cochrane Library from their inception to November 2020 for randomised controlled trials (RCTs) assessing probiotic supplements and osteoporosis in postmenopausal women. Study-specific risk estimates were combined using random-effect models. Five RCTs (n=497) were included. Probiotic supplements were associated with a significantly higher BMD in the lumbar spine (standardised mean difference, SMD=0.27, 95% CI 0.09 to 0.44) than in control. There was no difference between probiotic supplements and BMD in hips (SMD=0.22, 95% CI -0.07 to 0.52). Collagen type 1 cross-linked C-telopeptide levels in the treatment groups were significantly lower than those of the placebo group (SMD=-0.34, 95% CI -0.60 to -0.09). In subgroup meta-analysis, levels of bone-specific alkaline phosphatase, osteoprotegerin, osteocalcin and tumour necrosis factor did not differ between the probiotic and placebo groups. We conclude cautiously that supplementation with probiotics could increase lumbar BMD. More RCTs are recommended to validate or update these results.
ObjectiveOsteoporosis is a common disease in postmenopausal women. Several studies have analysed the associations between dietary supplementation with probiotics and bone health in postmenopausal women, but the results are still controversial. We conducted this meta-analysis to assess the effects of probiotics supplement on bone mineral density (BMD) and bone turnover markers for postmenopausal women.DesignSystematic review and meta-analysis.MethodsWe systematically searched PubMed, EMBASE and the Cochrane Library from their inception to November 2020 for randomised controlled trials (RCTs) assessing probiotic supplements and osteoporosis in postmenopausal women. Study-specific risk estimates were combined using random-effect models.ResultsFive RCTs (n=497) were included. Probiotic supplements were associated with a significantly higher BMD in the lumbar spine (standardised mean difference, SMD=0.27, 95% CI 0.09 to 0.44) than in control. There was no difference between probiotic supplements and BMD in hips (SMD=0.22, 95% CI −0.07 to 0.52). Collagen type 1 cross-linked C-telopeptide levels in the treatment groups were significantly lower than those of the placebo group (SMD=−0.34, 95% CI −0.60 to −0.09). In subgroup meta-analysis, levels of bone-specific alkaline phosphatase, osteoprotegerin, osteocalcin and tumour necrosis factor did not differ between the probiotic and placebo groups.ConclusionsWe conclude cautiously that supplementation with probiotics could increase lumbar BMD. More RCTs are recommended to validate or update these results.
Objective Osteoporosis is a common disease in postmenopausal women. Several studies have analysed the associations between dietary supplementation with probiotics and bone health in postmenopausal women, but the results are still controversial. We conducted this meta-analysis to assess the effects of probiotics supplement on bone mineral density (BMD) and bone turnover markers for postmenopausal women.Design Systematic review and meta-analysis.Methods We systematically searched PubMed, EMBASE and the Cochrane Library from their inception to November 2020 for randomised controlled trials (RCTs) assessing probiotic supplements and osteoporosis in postmenopausal women. Study-specific risk estimates were combined using random-effect models.Results Five RCTs (n=497) were included. Probiotic supplements were associated with a significantly higher BMD in the lumbar spine (standardised mean difference, SMD=0.27, 95% CI 0.09 to 0.44) than in control. There was no difference between probiotic supplements and BMD in hips (SMD=0.22, 95% CI −0.07 to 0.52). Collagen type 1 cross-linked C-telopeptide levels in the treatment groups were significantly lower than those of the placebo group (SMD=−0.34, 95% CI −0.60 to −0.09). In subgroup meta-analysis, levels of bone-specific alkaline phosphatase, osteoprotegerin, osteocalcin and tumour necrosis factor did not differ between the probiotic and placebo groups.Conclusions We conclude cautiously that supplementation with probiotics could increase lumbar BMD. More RCTs are recommended to validate or update these results.
Author Luo, Cong
Cai, Ming
Cao, Gaoyang
Yu, Jiafeng
Yuan, Shuohui
Yu, Jiawei
AuthorAffiliation 2 Department of Colorectal Surgery , Zhejiang University School of Medicine Sir Run Run Shaw Hospital , Hangzhou , China
1 Department of Orthopedic Surgery , Zhuji Affiliated Hospital of Wenzhou Medical University , Shaoxing , China
AuthorAffiliation_xml – name: 2 Department of Colorectal Surgery , Zhejiang University School of Medicine Sir Run Run Shaw Hospital , Hangzhou , China
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  organization: Department of Orthopedic Surgery, Zhuji Affiliated Hospital of Wenzhou Medical University, Shaoxing, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33653743$$D View this record in MEDLINE/PubMed
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Issue 3
Keywords bone diseases
spine
nutrition & dietetics
hip
Language English
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2021030207553594000_11.3.e041393.40
2021030207553594000_11.3.e041393.23
2021030207553594000_11.3.e041393.24
Parvaneh (2021030207553594000_11.3.e041393.30) 2015; 2015
Maekawa (2021030207553594000_11.3.e041393.38) 2014; 49
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2021030207553594000_11.3.e041393.16
2021030207553594000_11.3.e041393.17
Kim (2021030207553594000_11.3.e041393.27) 2009; 19
Scholz-Ahrens (2021030207553594000_11.3.e041393.32) 2016; 3
2021030207553594000_11.3.e041393.39
2021030207553594000_11.3.e041393.14
2021030207553594000_11.3.e041393.36
2021030207553594000_11.3.e041393.15
2021030207553594000_11.3.e041393.37
Jansson (2021030207553594000_11.3.e041393.22) 2019; 1
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2021030207553594000_11.3.e041393.19
2021030207553594000_11.3.e041393.31
Jafarnejad (2021030207553594000_11.3.e041393.20) 2017; 36
2021030207553594000_11.3.e041393.2
2021030207553594000_11.3.e041393.12
2021030207553594000_11.3.e041393.34
2021030207553594000_11.3.e041393.13
2021030207553594000_11.3.e041393.35
2021030207553594000_11.3.e041393.11
2021030207553594000_11.3.e041393.33
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2021030207553594000_11.3.e041393.8
Rodrigues (2021030207553594000_11.3.e041393.26) 2012; 15
Takimoto (2021030207553594000_11.3.e041393.18) 2018; 37
Clifton-Bligh (2021030207553594000_11.3.e041393.4) 2015; 69
2021030207553594000_11.3.e041393.9
Kanis (2021030207553594000_11.3.e041393.1) 2002; 359
De Franciscis (2021030207553594000_11.3.e041393.7) 2019; 55
2021030207553594000_11.3.e041393.28
2021030207553594000_11.3.e041393.25
2021030207553594000_11.3.e041393.29
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Snippet ObjectiveOsteoporosis is a common disease in postmenopausal women. Several studies have analysed the associations between dietary supplementation with...
Osteoporosis is a common disease in postmenopausal women. Several studies have analysed the associations between dietary supplementation with probiotics and...
Objective Osteoporosis is a common disease in postmenopausal women. Several studies have analysed the associations between dietary supplementation with...
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StartPage e041393
SubjectTerms Bias
Bone Density
bone diseases
Dietary Supplements
Evidence Based Practice
Female
hip
Humans
Meta-analysis
nutrition & dietetics
Osteoporosis
Osteoporosis, Postmenopausal - prevention & control
Patients
Phosphatase
Postmenopause
Probiotics
Randomized Controlled Trials as Topic
spine
Systematic review
Tumor necrosis factor-TNF
Womens health
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Title Probiotic supplements and bone health in postmenopausal women: a meta-analysis of randomised controlled trials
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