Nicotinamide as a Foundation for Treating Neurodegenerative Disease and Metabolic Disorders

• Published in: Current neurovascular research Vol. 18; no. 1; p. 134
• Main Author: Maiese, Kenneth
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2021
• Subjects: Animals; Humans; Metabolic Diseases - drug therapy; Metabolic Diseases - metabolism; Neurodegenerative Diseases - drug therapy; Neurodegenerative Diseases - metabolism; Niacinamide - pharmacology; Niacinamide - therapeutic use; Oxidative Stress - drug effects; Signal Transduction - drug effects; FoxO; stem cells; autophagy; mechanistic target of rapamycin (mTOR); apoptosis; diabetes mellitus; AMP activated protein kinase (AMPK); sirtuin; dementia; forkhead transcription factors; silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1); Alzheimer's disease; oxidative stress

Neurodegenerative disorders impact more than one billion individuals worldwide and are intimately tied to metabolic disease that can affect another nine hundred individuals throughout the globe. Nicotinamide is a critical agent that may offer fruitful prospects for neurodegenerative diseases and met...