Assessing the Heritability of Complex Traits in Humans: Methodological Challenges and Opportunities

• Published in: Current genomics Vol. 18; no. 4; pp. 332 - 340
• Main Authors: Mayhew, Alexandra J., Meyre, David
• Format: Journal Article
• Language: English
• Published: Netherlands Bentham Science Publishers Ltd 01.08.2017; Benham Science Publishers; Bentham Science Publishers
• Subjects: Epigenetics; Estimates; Genetic diversity; Genetic variance; Heritability; Mathematical models; Population studies; Regression analysis; Single-nucleotide polymorphism; Twin studies; Family studies; Missing heritability; Path analysis; Heritability; Twin studies; Complex traits

The goal of this review article is to provide a conceptual based summary of how heritability estimates for complex traits such as obesity are determined and to explore the future directions of research in the heritability field. The target audience are researchers who use heritability data rather th...