Apolipoprotein E-mediated Modulation of ADAM10 in Alzheimer's Disease

• Published in: Current Alzheimer research Vol. 14; no. 6; p. 578
• Main Authors: Shackleton, Ben, Crawford, Fiona, Bachmeier, Corbin
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2017
• Subjects: ADAM10 Protein - metabolism; Aged; Aged, 80 and over; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases - metabolism; Animals; Apolipoproteins E - genetics; Cerebral Cortex - metabolism; CHO Cells; Cricetulus; Female; Gene Expression Regulation - genetics; Humans; Male; Membrane Proteins - metabolism; Middle Aged; Protein Isoforms - genetics; Protein Isoforms - metabolism; Transfection; apolipoprotein E; ADAM10; amyloid; APOE; α-secretase; Alzheimer's Disease

The APOE4 allele is the strongest genetic risk factor for Alzheimer's disease (AD). It has been associated with an accumulation of amyloid-β (Aβ) in the brain, which is produced through the sequential cleavage of the amyloid-β precursor protein (AβPP) by β - and γ-secretases. Alternatively, AβP...