Hematopoietic Differentiation of Human Pluripotent Stem Cells: HOX and GATA Transcription Factors as Master Regulators

• Published in: Current genomics Vol. 20; no. 6; pp. 438 - 452
• Main Authors: Alsayegh, Khaled, Cortés-Medina, Lorena V., Ramos-Mandujano, Gerardo, Badraiq, Heba, Li, Mo
• Format: Journal Article
• Language: English
• Published: United Arab Emirates Bentham Science Publishers Ltd 01.09.2019; Benham Science Publishers; Bentham Science Publishers
• Subjects: Autografts; Blood; Cell culture; Cell differentiation; Cell therapy; Current Genomics; Disorders; Engraftment; Gene regulation; Hematological diseases; Hematopoiesis; Hematopoietic stem cells; Hematopoietic system; Homeobox; miRNA; Molecular modelling; Pluripotency; Regenerative medicine; Stem cell transplantation; Stem cells; Tissue engineering; Transcription factors; engraftment; differentiation; embryonic stem cell; induced pluripotent stem cell; Hematopoiesis; transcription factors; GATA; HOX genes; microRNA; epigenetic regulation

Numerous human disorders of the blood system would directly or indirectly benefit from therapeutic approaches that reconstitute the hematopoietic system. Hematopoietic stem cells (HSCs), either from matched donors or ex vivo manipulated autologous tissues, are the most used cellular source of cell t...