Hematopoietic Differentiation of Human Pluripotent Stem Cells: HOX and GATA Transcription Factors as Master Regulators

Numerous human disorders of the blood system would directly or indirectly benefit from therapeutic approaches that reconstitute the hematopoietic system. Hematopoietic stem cells (HSCs), either from matched donors or ex vivo manipulated autologous tissues, are the most used cellular source of cell t...

Full description

Saved in:
Bibliographic Details
Published inCurrent genomics Vol. 20; no. 6; pp. 438 - 452
Main Authors Alsayegh, Khaled, Cortés-Medina, Lorena V., Ramos-Mandujano, Gerardo, Badraiq, Heba, Li, Mo
Format Journal Article
LanguageEnglish
Published United Arab Emirates Bentham Science Publishers Ltd 01.09.2019
Benham Science Publishers
Bentham Science Publishers
Subjects
Autografts
Blood
Cell culture
Cell differentiation
Cell therapy
Current Genomics
Disorders
Engraftment
Gene regulation
Hematological diseases
Hematopoiesis
Hematopoietic stem cells
Hematopoietic system
Homeobox
miRNA
Molecular modelling
Pluripotency
Regenerative medicine
Stem cell transplantation
Stem cells
Tissue engineering
Transcription factors
engraftment
differentiation
embryonic stem cell
induced pluripotent stem cell
Hematopoiesis
transcription factors
GATA
HOX genes
microRNA
epigenetic regulation
Online AccessGet full text

Cover

Abstract Numerous human disorders of the blood system would directly or indirectly benefit from therapeutic approaches that reconstitute the hematopoietic system. Hematopoietic stem cells (HSCs), either from matched donors or ex vivo manipulated autologous tissues, are the most used cellular source of cell therapy for a wide range of disorders. Due to the scarcity of matched donors and the difficulty of ex vivo expansion of HSCs, there is a growing interest in harnessing the potential of pluripotent stem cells (PSCs) as a de novo source of HSCs. PSCs make an ideal source of cells for regenerative medicine in general and for treating blood disorders in particular because they could expand indefinitely in culture and differentiate to any cell type in the body. However, advancement in deriving functional HSCs from PSCs has been slow. This is partly due to an incomplete understanding of the molecular mechanisms underlying normal hematopoiesis. In this review, we discuss the latest efforts to generate human PSC (hPSC)-derived HSCs capable of long-term engraftment. We review the regulation of the key transcription factors (TFs) in hematopoiesis and hematopoietic differentiation, the Homeobox (HOX) and GATA genes, and the interplay between them and microRNAs. We also propose that precise control of these master regulators during the course of hematopoietic differentiation is key to achieving functional hPSC-derived HSCs.
AbstractList Numerous human disorders of the blood system would directly or indirectly benefit from therapeutic approaches that reconstitute the hematopoietic system. Hematopoietic stem cells (HSCs), either from matched donors or ex vivo manipulated autologous tissues, are the most used cellular source of cell therapy for a wide range of disorders. Due to the scarcity of matched donors and the difficulty of ex vivo expansion of HSCs, there is a growing interest in harnessing the potential of pluripotent stem cells (PSCs) as a de novo source of HSCs. PSCs make an ideal source of cells for regenerative medicine in general and for treating blood disorders in particular because they could expand indefinitely in culture and differentiate to any cell type in the body. However, advancement in deriving functional HSCs from PSCs has been slow. This is partly due to an incomplete understanding of the molecular mechanisms underlying normal hematopoiesis. In this review, we discuss the latest efforts to generate human PSC (hPSC)-derived HSCs capable of long-term engraftment. We review the regulation of the key transcription factors (TFs) in hematopoiesis and hematopoietic differentiation, the Homeobox (HOX) and GATA genes, and the interplay between them and microRNAs. We also propose that precise control of these master regulators during the course of hematopoietic differentiation is key to achieving functional hPSC-derived HSCs.Numerous human disorders of the blood system would directly or indirectly benefit from therapeutic approaches that reconstitute the hematopoietic system. Hematopoietic stem cells (HSCs), either from matched donors or ex vivo manipulated autologous tissues, are the most used cellular source of cell therapy for a wide range of disorders. Due to the scarcity of matched donors and the difficulty of ex vivo expansion of HSCs, there is a growing interest in harnessing the potential of pluripotent stem cells (PSCs) as a de novo source of HSCs. PSCs make an ideal source of cells for regenerative medicine in general and for treating blood disorders in particular because they could expand indefinitely in culture and differentiate to any cell type in the body. However, advancement in deriving functional HSCs from PSCs has been slow. This is partly due to an incomplete understanding of the molecular mechanisms underlying normal hematopoiesis. In this review, we discuss the latest efforts to generate human PSC (hPSC)-derived HSCs capable of long-term engraftment. We review the regulation of the key transcription factors (TFs) in hematopoiesis and hematopoietic differentiation, the Homeobox (HOX) and GATA genes, and the interplay between them and microRNAs. We also propose that precise control of these master regulators during the course of hematopoietic differentiation is key to achieving functional hPSC-derived HSCs.
Numerous human disorders of the blood system would directly or indirectly benefit from therapeutic approaches that reconstitute the hematopoietic system. Hematopoietic stem cells (HSCs), either from matched donors or ex vivo manipulated autologous tissues, are the most used cellular source of cell therapy for a wide range of disorders. Due to the scarcity of matched donors and the difficulty of ex vivo expansion of HSCs, there is a growing interest in harnessing the potential of pluripotent stem cells (PSCs) as a de novo source of HSCs. PSCs make an ideal source of cells for regenerative medicine in general and for treating blood disorders in particular because they could expand indefinitely in culture and differentiate to any cell type in the body. However, advancement in deriving functional HSCs from PSCs has been slow. This is partly due to an incomplete understanding of the molecular mechanisms underlying normal hematopoiesis. In this review, we discuss the latest efforts to generate human PSC (hPSC)-derived HSCs capable of long-term engraftment. We review the regulation of the key transcription factors (TFs) in hematopoiesis and hematopoietic differentiation, the Homeobox (HOX) and GATA genes, and the interplay between them and microRNAs. We also propose that precise control of these master regulators during the course of hematopoietic differentiation is key to achieving functional hPSC-derived HSCs.
Numerous human disorders of the blood system would directly or indirectly benefit from therapeutic approaches that reconstitute the hematopoietic system. Hematopoietic stem cells (HSCs), either from matched donors or ex vivo manipulated autologous tissues, are the most used cellular source of cell therapy for a wide range of disorders. Due to the scarcity of matched donors and the difficulty of ex vivo expansion of HSCs, there is a growing interest in harnessing the potential of pluripotent stem cells (PSCs) as a de novo source of HSCs. PSCs make an ideal source of cells for regenerative medicine in general and for treating blood disorders in particular because they could expand indefinitely in culture and differentiate to any cell type in the body. However, advancement in deriving functional HSCs from PSCs has been slow. This is partly due to an incomplete understanding of the molecular mechanisms underlying normal hematopoiesis. In this review, we discuss the latest efforts to generate human PSC (hPSC)-derived HSCs capable of long-term engraftment. We review the regulation of the key transcription factors (TFs) in hematopoiesis and hematopoietic differentiation, the Homeobox (HOX) and GATA genes, and the interplay between them and microRNAs. We also propose that precise control of these master regulators during the course of hematopoietic differentiation is key to achieving functional hPSC-derived HSCs.
Numerous human disorders of the blood system would directly or indirectly benefit from therapeutic approaches that reconstitute the hematopoietic system. Hematopoietic stem cells (HSCs), either from matched donors or manipulated autologous tissues, are the most used cellular source of cell therapy for a wide range of disorders. Due to the scarcity of matched donors and the difficulty of expansion of HSCs, there is a growing interest in harnessing the potential of pluripotent stem cells (PSCs) as a source of HSCs. PSCs make an ideal source of cells for regenerative medicine in general and for treating blood disorders in particular because they could expand indefinitely in culture and differentiate to any cell type in the body. However, advancement in deriving functional HSCs from PSCs has been slow. This is partly due to an incomplete understanding of the molecular mechanisms underlying normal hematopoiesis. In this review, we discuss the latest efforts to generate human PSC (hPSC)-derived HSCs capable of long-term engraftment. We review the regulation of the key transcription factors (TFs) in hematopoiesis and hematopoietic differentiation, the Homeobox (HOX) and GATA genes, and the interplay between them and microRNAs. We also propose that precise control of these master regulators during the course of hematopoietic differentiation is key to achieving functional hPSC-derived HSCs.
Author Heba Badraiq
Lorena V. Cortés-Medina
Mo Li
Khaled Alsayegh
Gerardo Ramos-Mandujano
Author_xml – sequence: 1
  givenname: Khaled
  orcidid: 0000-0003-2654-835X
  surname: Alsayegh
  fullname: Alsayegh, Khaled
  organization: King Abdullah International Medical Research Centre, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia
– sequence: 2
  givenname: Lorena V.
  orcidid: 0000-0001-7718-0730
  surname: Cortés-Medina
  fullname: Cortés-Medina, Lorena V.
  organization: Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
– sequence: 3
  givenname: Gerardo
  orcidid: 0000-0002-5019-4291
  surname: Ramos-Mandujano
  fullname: Ramos-Mandujano, Gerardo
  organization: Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
– sequence: 4
  givenname: Heba
  orcidid: 0000-0002-9518-3262
  surname: Badraiq
  fullname: Badraiq, Heba
  organization: King Abdullah International Medical Research Centre, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia
– sequence: 5
  givenname: Mo
  orcidid: 0000-0003-0827-8907
  surname: Li
  fullname: Li, Mo
  organization: Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32194342$$D View this record in MEDLINE/PubMed
BookMark eNqNkk1vEzEQhleoiH7AX0BGXLgE_LVfHEBRoA1SUREEidvIcWYTl117sb2JuPPD8SZtBZWQOFgeeZ5557U9p9mRdRaz7BmjLzkr5SsmqppTnlZRFKxmlJWsEJUoH2QnrCrzSS6r6ijFiZuM4HF2GsI1pZxWJX2UHQvOaikkP8m2c-xUdL0zGI0m70zToEcbjYrGWeIaMh86ZcmndvCmdzGlyJeIHZlh24bXZH71jSi7IhfTxZQsvLJBJ25fe650dD4QFchHFSJ68hnXQ6vGw8fZw0a1AZ_c7GfZ1_P3i9l8cnl18WE2vZws87KIE8mrqhZ5rRkylKpa6obxpkCZ84bKipdY5TWtBWpal2IluCpErlnNBddaN1qcZW8Ouv2w7HClk32vWui96ZT_CU4Z-DtjzQbWbgslLTiVPAm8uBHw7seAIUJngk53VxbdEICLiiVSUJnQ5_fQazd4m66XKCFFyWQ5Uk__dHRn5fZLEvD2AGjvQvDYgDZx_xvJoGmBURiHAP45BEmhvqdw2-R_an8dapfpQTaqC9qg1XinsImxh91uBzh4_K4CtqgjaNeB69EOvk2xHacE-k0Pa7QeQfk0Wi2CCcHuW8PYG7auHTpM8ZgYEAoIvVojyGTkN21D6C0
CitedBy_id crossref_primary_10_1007_s13353_024_00868_x
crossref_primary_10_2174_138920292006191206141546
crossref_primary_10_3389_fcell_2022_1002909
crossref_primary_10_1007_s11427_024_2816_0
crossref_primary_10_1089_scd_2020_0194
crossref_primary_10_1016_j_celrep_2020_108465
crossref_primary_10_1016_j_envpol_2025_126077
crossref_primary_10_1155_2021_9919422
crossref_primary_10_3389_fcell_2023_1188905
crossref_primary_10_1242_dev_192476
crossref_primary_10_1080_09674845_2021_1877926
crossref_primary_10_3389_fgene_2020_577053
crossref_primary_10_1016_j_humgen_2024_201318
crossref_primary_10_1039_D1BM00442E
crossref_primary_10_1371_journal_pone_0283934
crossref_primary_10_7554_eLife_86493
Cites_doi 10.1038/sj.onc.1210760
10.1073/pnas.0703082104
10.4049/jimmunol.0803670
10.1016/j.stemcr.2018.05.002
10.1128/MCB.25.7.2832-2845.2005
10.1038/sj.emboj.7600703
10.1038/cr.2011.186
10.1038/ni.2692
10.1182/blood-2008-07-169417
10.1073/pnas.0712312105
10.1182/blood-2006-02-003327
10.1016/j.cell.2017.04.018
10.1182/blood-2012-08-450494
10.1186/s13148-019-0617-1
10.1200/JCO.2000.18.6.1360
10.1242/jcs.096032
10.1186/scrt222
10.4414/smw.2011.13316
10.1038/nrm3393
10.1186/s13619-015-0018-7
10.1182/blood-2014-03-558825
10.1289/ehp.114-a160
10.1038/pr.2011.57
10.1074/jbc.M112.370437
10.18632/oncotarget.6198
10.1002/stem.2562
10.1084/jem.20041888
10.1126/science.1097434
10.1038/protex.2017.012
10.1038/cr.2012.4
10.1371/journal.pone.0152234
10.5966/sctm.2015-0324
10.1038/mt.2014.196
10.1038/ncomms1681
10.1101/gr.164830.113
10.1016/S0092-8674(02)00680-3
10.1182/blood-2003-03-0832
10.1016/j.stem.2008.06.001
10.1016/j.stemcr.2018.11.001
10.1073/pnas.0800090105
10.1038/nature22370
10.1101/gr.184978.114
10.1038/sj.leu.2404396
10.1073/pnas.1016218107
10.1038/nbt.2915
10.1016/j.cell.2018.03.006
10.1016/j.exphem.2008.06.001
10.1074/jbc.R113.488247
10.1634/stemcells.2005-0210
10.4143/crt.2014.46.3.209
10.1182/blood-2017-06-788695
10.1016/j.tcb.2015.10.002
10.1016/j.cell.2013.08.055
10.1038/onc.2010.484
10.1111/bjh.14378
10.1101/gr.2722704
10.1016/j.celrep.2012.11.003
10.1007/s12185-014-1568-0
10.1182/blood-2006-09-048322
10.1126/science.282.5391.1145
10.1101/gad.284109.116
10.1182/bloodadvances.2017013342
10.1002/stem.1036
10.1038/leu.2008.141
10.1182/blood.V96.4.1591
10.1182/blood-2011-03-341081
10.1016/j.it.2018.11.005
10.1016/j.molcel.2009.11.001
10.1002/stem.2332
10.1371/journal.pone.0142400
10.1182/blood-2011-01-331686
10.1016/j.devcel.2007.11.006
10.1182/blood-2012-08-451641
10.1007/s11033-007-9171-6
10.1038/sj.onc.1210755
10.1242/dev.021121
10.1111/j.1600-065X.2010.00954.x
10.1182/blood-2016-12-754051
10.1182/blood-2007-03-079681
10.1038/cdd.2016.111
10.1038/emboj.2011.390
10.1038/sj.emboj.7600702
10.1016/j.stemcr.2019.07.009
10.1038/ng1679
10.1182/blood-2011-12-396754
10.1242/dev.02731
10.1155/2017/1286246
10.1038/ncomms5372
10.1089/scd.2014.0318
10.1128/MCB.24.15.6824-6836.2004
10.4252/wjsc.v7.i3.583
10.1371/journal.pgen.1006887
10.1074/jbc.M110.157545
10.1182/blood-2014-11-612465
10.1534/genetics.114.173492
10.1182/blood-2008-01-136218
10.1182/blood-2011-05-352518
10.1182/blood-2008-06-162164
10.1073/pnas.0506216102
10.3324/haematol.2008.002436
10.1155/2018/3569493
10.1182/blood-2006-07-032847
10.1182/blood-2012-06-434407
10.1016/j.stem.2016.06.019
10.1186/scrt474
10.1038/mt.2012.49
10.1172/JCI61619
10.1016/j.celrep.2018.11.032
10.1152/physrev.00046.2011
10.1038/nature13547
10.4049/jimmunol.1801027
10.1387/ijdb.180206at
10.1093/nar/gks281
10.1182/blood-2016-09-687871
10.1073/pnas.0307612100
10.1016/j.cell.2006.07.024
10.4049/jimmunol.176.5.2924
10.1016/j.biocel.2011.12.004
10.1038/leu.2010.104
10.1242/dev.083147
10.1016/bs.ctdb.2016.01.004
10.1016/j.exphem.2016.06.005
10.1038/nrg.2016.156
10.1182/blood.V89.6.1922
10.1073/pnas.1432147100
10.1038/nature22326
10.1093/nar/gkt848
10.1016/j.stem.2014.06.016
10.2174/1574888X10666151026114241
10.1016/S0301-472X(00)00169-7
10.1182/blood-2008-11-190215
10.1242/dev.121.1.163
10.1093/nar/gkz267
10.1016/j.stem.2013.09.002
10.1073/pnas.0913574107
10.1182/blood-2012-08-450627
10.1016/j.transproceed.2016.03.014
10.1016/j.stem.2007.10.011
10.1002/pro.3122
10.1182/blood-2007-10-117622
10.1016/j.molcel.2012.10.008
10.1182/blood-2005-05-2003
10.1016/j.stem.2007.10.022
10.15252/emmm.201505301
10.1182/blood-2010-12-323212
10.1007/s00005-011-0147-9
10.1038/ncb3354
10.1038/nature09819
10.1016/j.stem.2010.07.016
10.1073/pnas.1718446115
10.1038/ncomms5330
ContentType Journal Article
Copyright 2019 Bentham Science Publishers.
Copyright Bentham Science Sep 2019
2019 Bentham Science Publishers 2019
Copyright_xml – notice: 2019 Bentham Science Publishers.
– notice: Copyright Bentham Science Sep 2019
– notice: 2019 Bentham Science Publishers 2019
DBID AAYXX
CITATION
NPM
7QL
7QO
7QP
7SS
7T7
7TK
7TM
7U9
8FD
C1K
FR3
H94
M7N
P64
RC3
7X8
5PM
DOI 10.2174/1389202920666191017163837
DatabaseName CrossRef
PubMed
Bacteriology Abstracts (Microbiology B)
Biotechnology Research Abstracts
Calcium & Calcified Tissue Abstracts
Entomology Abstracts (Full archive)
Industrial and Applied Microbiology Abstracts (Microbiology A)
Neurosciences Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Technology Research Database
Environmental Sciences and Pollution Management
Engineering Research Database
AIDS and Cancer Research Abstracts
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
PubMed
Virology and AIDS Abstracts
Technology Research Database
Nucleic Acids Abstracts
Neurosciences Abstracts
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
Entomology Abstracts
Genetics Abstracts
Biotechnology Research Abstracts
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
AIDS and Cancer Research Abstracts
Engineering Research Database
Industrial and Applied Microbiology Abstracts (Microbiology A)
Calcium & Calcified Tissue Abstracts
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
Virology and AIDS Abstracts


PubMed
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1875-5488
EndPage 452
ExternalDocumentID PMC7062042
32194342
10_2174_1389202920666191017163837
http_www_eurekaselect_com_openurl_content_php_genre_article_issn_1389_2029_volume_20_issue_6_spage_438
Genre Journal Article
Review
GroupedDBID -
0R
29F
2WC
4.4
5.
53G
5GY
AAEGP
ABPTK
ACGFS
ACIWK
ACPRK
ADACO
ADBBV
AENEX
AFRAH
AFUQM
AGJNZ
ALMA_UNASSIGNED_HOLDINGS
BAWUL
C1A
CS3
DIK
DU5
E3Z
EBS
EJD
F5P
GH2
GX1
HYE
HZ
KCGFV
O9-
OK1
P2P
RIG
RPM
---
.5.
0R~
AAYXX
ABEEF
ABJNI
AFHZU
ANTIV
AOIJS
CITATION
HZ~
IPNFZ
TR2
NPM
7QL
7QO
7QP
7SS
7T7
7TK
7TM
7U9
8FD
C1K
FR3
H94
M7N
P64
RC3
7X8
5PM
ID FETCH-LOGICAL-b576t-42889359c1e1e4a8bcf12f6e452f04827e859093ec0973d32a635c19232cccfc3
ISSN 1389-2029
IngestDate Thu Aug 21 18:40:50 EDT 2025
Fri Jul 11 04:35:50 EDT 2025
Thu Jul 17 16:51:34 EDT 2025
Thu Jan 02 22:58:36 EST 2025
Thu Apr 24 23:05:32 EDT 2025
Tue Jul 01 02:59:06 EDT 2025
Tue Jan 05 18:20:15 EST 2021
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6
Keywords engraftment
differentiation
embryonic stem cell
induced pluripotent stem cell
Hematopoiesis
transcription factors
GATA
HOX genes
microRNA
epigenetic regulation
Language English
License 2019 Bentham Science Publishers.
This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-b576t-42889359c1e1e4a8bcf12f6e452f04827e859093ec0973d32a635c19232cccfc3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0003-2654-835X
0000-0002-5019-4291
0000-0003-0827-8907
0000-0001-7718-0730
0000-0002-9518-3262
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC7062042
PMID 32194342
PQID 2334371474
PQPubID 2048057
PageCount 15
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_7062042
proquest_miscellaneous_2381620304
proquest_journals_2334371474
pubmed_primary_32194342
crossref_citationtrail_10_2174_1389202920666191017163837
crossref_primary_10_2174_1389202920666191017163837
benthamscience_primary_http_www_eurekaselect_com_openurl_content_php_genre_article_issn_1389_2029_volume_20_issue_6_spage_438
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20190901
PublicationDateYYYYMMDD 2019-09-01
PublicationDate_xml – month: 9
  year: 2019
  text: 20190901
  day: 1
PublicationDecade 2010
PublicationPlace United Arab Emirates
PublicationPlace_xml – name: United Arab Emirates
– name: Sharjah
PublicationTitle Current genomics
PublicationTitleAlternate CG
PublicationYear 2019
Publisher Bentham Science Publishers Ltd
Benham Science Publishers
Bentham Science Publishers
Publisher_xml – name: Bentham Science Publishers Ltd
– name: Benham Science Publishers
– name: Bentham Science Publishers
References Tran F.H. (ref=140) 2017; 26
Jackson M. (ref=47) 2016; 5
Pevny L. (ref=88) 1995; 121
Elcheva I. (ref=33) 2014; 5
Wang K.C. (ref=82) 2011; 472
Velu C.S. (ref=125) 2009; 113
Gerrits A. (ref=122) 2012; 119
Bowles K.M. (ref=46) 2006; 24
Bueno C. (ref=73) 2012; 22
Seifert A. (ref=66) 2015; 7
Chung N. (ref=74) 2009; 36
Espinoza J.L. (ref=55) 2018; 2
Takizawa H. (ref=8) 2011; 141
Lawrence H.J. (ref=68) 1997; 89
Porcher C. (ref=113) 2017; 129
Siena S. (ref=6) 2000; 18
Marshall C.J. (ref=135) 2000; 96
Li M. (ref=152) 2014; 289
Slany R.K. (ref=75) 2009; 94
Rodrigues N.P. (ref=118) 2012; 44
Campos-Sanchez E. (ref=5) 2019; 40
Timmermans F. (ref=27) 2009; 182
Lennartsson J. (ref=132) 2012; 92
Ramos-Mejía V. (ref=70) 2014; 124
Ooi A.G. (ref=123) 2010; 107
Liu G.H. (ref=155) 2014; 5
Zhao H. (ref=126) 2009; 113
Li M. (ref=43) 2012; 13
Dore L.C. (ref=127) 2008; 105
Zhang Y. (ref=107) 2012; 125
Huang K. (ref=89) 2015; 4
Kang H. (ref=95) 2018; 11
Rodriguez P. (ref=112) 2005; 24
Hoang T. (ref=115) 2016; 118
Tan Y.T. (ref=52) 2018; 115
Bhatlekar S. (ref=80) 2018; 2018
French A. (ref=28) 2015; 24
De Kumar B. (ref=78) 2015; 25
Kumar A. (ref=26) 2019; 202
Erfurth F.E. (ref=76) 2008; 105
Liso A. (ref=13) 2017; 2017
Cabezas-Wallscheid N. (ref=58) 2017; 169
Lugus J.J. (ref=86) 2007; 134
Sandler V.M. (ref=37) 2014; 511
Okuno Y. (ref=108) 2005; 25
Rodriguez A. (ref=120) 2004; 14
Yekta S. (ref=124) 2004; 304
Rice K.L. (ref=143) 2007; 26
Jagannathan-Bogdan M. (ref=2) 2013; 140
Argiropoulos B. (ref=44) 2007; 26
Mancini E. (ref=104) 2012; 31
Burda P. (ref=110) 2010; 24
Kim A.R. (ref=19) 2016; 44
Dou D.R. (ref=71) 2016; 18
Daniel M.G. (ref=1) 2016; 26
Real P.J. (ref=35) 2012; 20
Shojaei F. (ref=69) 2008; 36
Gutiérrez L. (ref=84) 2007; 110
Tsuzuki S. (ref=98) 2004; 24
Wu W. (ref=114) 2014; 24
Bartel D.P. (ref=119) 2018; 173
Guo S. (ref=15) 2010; 107
Weerkamp F. (ref=41) 2006; 20
Turkistany S.A. (ref=105) 2011; 59
Sugimura R. (ref=36) 2017; 545
Hu D. (ref=145) 2016; 30
Yan J. (ref=146) 2013; 121
Weinhold B. (ref=4) 2006; 114
Lis R. (ref=38) 2017; 545
Yang C.T. (ref=11) 2017; 35
Li Z. (ref=121) 2012; 3
Daikeler T. (ref=17) 2012; 71
Burda P. (ref=106) 2016; 11
Metcalf D. (ref=130) 2008; 111
Chadwick K. (ref=134) 2003; 102
Felli N. (ref=131) 2005; 102
Grass J.A. (ref=94) 2003; 100
Kennedy M. (ref=31) 2012; 2
Collins E.M. (ref=56) 2018; 62
Kaneko H. (ref=96) 2012; 287
Lamonica J.M. (ref=103) 2006; 108
Cypris O. (ref=150) 2019; 11
Ohmori S. (ref=92) 2015; 125
Kyba M. (ref=60) 2002; 109
Nishizawa M. (ref=149) 2016; 19
King N.M. (ref=21) 2014; 5
Ran D. (ref=34) 2013; 121
Truong V.A. (ref=151) 2019; 47
Chanda B. (ref=142) 2013; 155
Castano J. (ref=156); 13
Vodyanik M.A. (ref=25) 2006; 108
Bresnick E.H. (ref=45) 2012; 40
Hosoya T. (ref=87) 2010; 238
Rosenbauer F. (ref=109) 2006; 38
Moriguchi T. (ref=85) 2014; 100
Hong W. (ref=102) 2005; 24
Cioch M. (ref=18) 2016; 48
Schiedlmeier B. (ref=62) 2007; 104
Oshima M. (ref=64) 2011; 117
Watts M.J. (ref=20) 2016; 175
Wang L. (ref=61) 2005; 201
Ledran M.H. (ref=23) 2008; 3
Malinge S. (ref=117) 2013; 121
Slukvin I.I. (ref=24) 2006; 176
Sumi T. (ref=136) 2008; 135
Lim K.C. (ref=91) 2012; 122
Saxena S. (ref=53) 2017
He H. (ref=72) 2011; 30
Li M. (ref=153) 2011; 21
Alvarez-Dominguez J.R. (ref=77) 2017; 130
Zardo G. (ref=67) 2008; 22
(ref=51) 2019
Amabile G. (ref=48) 2013; 121
Deans C. (ref=3) 2015; 199
Takayama N. (ref=29) 2008; 111
Fujiwara T. (ref=93) 2009; 36
Dalby A. (ref=50) 2018; 11
Ackermann M. (ref=22) 2015; 7
Verheyen E.M. (ref=137) 2007; 13
Thomson J.A. (ref=9) 1998; 282
Lawrence H.J. (ref=40) 2005; 106
Toscano M.G. (ref=49) 2015; 23
Forrester L.M. (ref=63) 2012; 30
Sweeney C.L. (ref=54) 2016; 34
Katsumura K.R. (ref=101) 2017; 129
Chanda B. (ref=57) 2013; 155
Pal S. (ref=100) 2004; 101
Wang F. (ref=129) 2014; 42
Zhang X. (ref=81) 2009; 113
Sturgeon C.M. (ref=30) 2014; 32
Li M. (ref=42) 2017; 18
Suzuki K. (ref=154) 2014; 15
Huang Y. (ref=39) 2012; 119
Nostro M.C. (ref=139) 2008; 2
Chivu-Economescu M. (ref=12) 2017; 12
Matsunaga H. (ref=97) 2015; 10
Kurkewich J.L. (ref=128) 2017; 13
Lee J.Y. (ref=133) 2018; 41
Asangani I.A. (ref=148) 2013; 49
Weiss M.J. (ref=83) 1995; 23
Wilson N.K. (ref=99) 2010; 7
Gomes A.M. (ref=116) 2018; 25
Chen Z.H. (ref=79) 2017; 24
Sturgeon C.M. (ref=141) 2014; 32
Frelin C. (ref=90) 2013; 14
Michallet M. (ref=16) 2000; 28
Herviou L. (ref=144) 2016; 7
Doulatov S. (ref=32) 2013; 13
Tripic T. (ref=111) 2009; 113
Lim W.F. (ref=7) 2013; 4
Fan R. (ref=65) 2012; 119
Takahashi K. (ref=10) 2006; 126
Champlin R. (ref=14) 2011; 118
Yamaguchi H. (ref=147) 2014; 46
Lengerke C. (ref=138) 2008; 2
Kashyap V. (ref=59) 2011; 286
References_xml – volume: 26
  start-page: 6766
  year: 2007
  ident: ref=44
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1210760
– volume: 104
  start-page: 16952
  year: 2007
  ident: ref=62
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0703082104
– volume: 182
  start-page: 6879
  year: 2009
  ident: ref=27
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0803670
– volume: 11
  start-page: 197
  year: 2018
  ident: ref=95
  publication-title: Stem Cell Reports
  doi: 10.1016/j.stemcr.2018.05.002
– volume: 25
  start-page: 2832
  year: 2005
  ident: ref=108
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.25.7.2832-2845.2005
– volume: 24
  start-page: 2367
  year: 2005
  ident: ref=102
  publication-title: EMBO J
  doi: 10.1038/sj.emboj.7600703
– volume: 21
  start-page: 1740
  year: 2011
  ident: ref=153
  publication-title: Cell Res
  doi: 10.1038/cr.2011.186
– volume: 14
  start-page: 1037
  year: 2013
  ident: ref=90
  publication-title: Nat Immunol
  doi: 10.1038/ni.2692
– volume: 113
  start-page: 2191
  year: 2009
  ident: ref=111
  publication-title: Blood
  doi: 10.1182/blood-2008-07-169417
– volume: 105
  start-page: 3333
  year: 2008
  ident: ref=127
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0712312105
– volume: 108
  start-page: 2095
  year: 2006
  ident: ref=25
  publication-title: Blood
  doi: 10.1182/blood-2006-02-003327
– volume: 169
  start-page: 807
  year: 2017
  ident: ref=58
  publication-title: Cell
  doi: 10.1016/j.cell.2017.04.018
– volume: 121
  start-page: 4512
  year: 2013
  ident: ref=146
  publication-title: Blood
  doi: 10.1182/blood-2012-08-450494
– volume: 11
  start-page: 19
  year: 2019
  ident: ref=150
  publication-title: Clin Epigenetics
  doi: 10.1186/s13148-019-0617-1
– volume: 18
  start-page: 1360
  year: 2000
  ident: ref=6
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2000.18.6.1360
– volume: 125
  start-page: 5609
  year: 2012
  ident: ref=107
  publication-title: J Cell Sci
  doi: 10.1242/jcs.096032
– volume: 4
  start-page: 71
  year: 2013
  ident: ref=7
  publication-title: Stem Cell Res Ther
  doi: 10.1186/scrt222
– volume: 141
  year: 2011
  ident: ref=8
  publication-title: Swiss Med Wkly
  doi: 10.4414/smw.2011.13316
– volume: 13
  start-page: 524
  year: 2012
  ident: ref=43
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm3393
– volume: 4
  start-page: 4
  year: 2015
  ident: ref=89
  publication-title: Cell Regen (Lond)
  doi: 10.1186/s13619-015-0018-7
– volume: 124
  start-page: 3065
  year: 2014
  ident: ref=70
  publication-title: Blood
  doi: 10.1182/blood-2014-03-558825
– volume: 114
  start-page: A160
  year: 2006
  ident: ref=4
  publication-title: Environ Health Perspect
  doi: 10.1289/ehp.114-a160
– volume: 71
  start-page: 439
  year: 2012
  ident: ref=17
  publication-title: Pediatr Res
  doi: 10.1038/pr.2011.57
– volume: 287
  start-page: 21439
  year: 2012
  ident: ref=96
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M112.370437
– volume: 7
  start-page: 2284
  year: 2016
  ident: ref=144
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.6198
– volume: 35
  start-page: 886
  year: 2017
  ident: ref=11
  publication-title: Stem Cells
  doi: 10.1002/stem.2562
– volume: 201
  start-page: 1603
  year: 2005
  ident: ref=61
  publication-title: J Exp Med
  doi: 10.1084/jem.20041888
– volume: 304
  start-page: 594
  year: 2004
  ident: ref=124
  publication-title: Science
  doi: 10.1126/science.1097434
– year: 2017
  ident: ref=53
  publication-title: Efficient production of human hematopoietic cells from pluripotent stem cells through cAMP induction
  doi: 10.1038/protex.2017.012
– volume: 22
  start-page: 986
  year: 2012
  ident: ref=73
  publication-title: Cell Res
  doi: 10.1038/cr.2012.4
– volume: 11
  year: 2016
  ident: ref=106
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0152234
– volume: 5
  start-page: 981
  year: 2016
  ident: ref=47
  publication-title: Stem Cells Transl Med
  doi: 10.5966/sctm.2015-0324
– volume: 23
  start-page: 158
  year: 2015
  ident: ref=49
  publication-title: Mol Ther
  doi: 10.1038/mt.2014.196
– volume: 3
  start-page: 688
  year: 2012
  ident: ref=121
  publication-title: Nat Commun
  doi: 10.1038/ncomms1681
– volume: 24
  start-page: 1945
  year: 2014
  ident: ref=114
  publication-title: Genome Res
  doi: 10.1101/gr.164830.113
– volume: 109
  start-page: 29
  year: 2002
  ident: ref=60
  publication-title: Cell
  doi: 10.1016/S0092-8674(02)00680-3
– volume: 23
  start-page: 99
  year: 1995
  ident: ref=83
  publication-title: Exp Hematol
– volume: 102
  start-page: 906
  year: 2003
  ident: ref=134
  publication-title: Blood
  doi: 10.1182/blood-2003-03-0832
– volume: 3
  start-page: 85
  year: 2008
  ident: ref=23
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.06.001
– volume: 11
  start-page: 1462
  year: 2018
  ident: ref=50
  publication-title: Stem Cell Reports
  doi: 10.1016/j.stemcr.2018.11.001
– volume: 105
  start-page: 7517
  year: 2008
  ident: ref=76
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0800090105
– volume: 545
  start-page: 432
  year: 2017
  ident: ref=36
  publication-title: Nature
  doi: 10.1038/nature22370
– volume: 25
  start-page: 1229
  year: 2015
  ident: ref=78
  publication-title: Genome Res
  doi: 10.1101/gr.184978.114
– volume: 20
  start-page: 1967
  year: 2006
  ident: ref=41
  publication-title: Leukemia
  doi: 10.1038/sj.leu.2404396
– volume: 107
  start-page: 21505
  year: 2010
  ident: ref=123
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1016218107
– volume: 32
  start-page: 554
  year: 2014
  ident: ref=141
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.2915
– volume: 173
  start-page: 20
  year: 2018
  ident: ref=119
  publication-title: Cell
  doi: 10.1016/j.cell.2018.03.006
– volume: 36
  start-page: 1436
  year: 2008
  ident: ref=69
  publication-title: Exp Hematol
  doi: 10.1016/j.exphem.2008.06.001
– volume: 289
  start-page: 4594
  year: 2014
  ident: ref=152
  publication-title: J Biol Chem
  doi: 10.1074/jbc.R113.488247
– volume: 24
  start-page: 1359
  year: 2006
  ident: ref=46
  publication-title: Stem Cells
  doi: 10.1634/stemcells.2005-0210
– volume: 46
  start-page: 209
  year: 2014
  ident: ref=147
  publication-title: Cancer Res Treat
  doi: 10.4143/crt.2014.46.3.209
– volume: 130
  start-page: 1965
  year: 2017
  ident: ref=77
  publication-title: Blood
  doi: 10.1182/blood-2017-06-788695
– volume: 26
  start-page: 202
  year: 2016
  ident: ref=1
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2015.10.002
– volume: 155
  start-page: 215
  year: 2013
  ident: ref=57
  publication-title: Cell
  doi: 10.1016/j.cell.2013.08.055
– volume: 30
  start-page: 379
  year: 2011
  ident: ref=72
  publication-title: Oncogene
  doi: 10.1038/onc.2010.484
– volume: 175
  start-page: 771
  year: 2016
  ident: ref=20
  publication-title: Br J Haematol
  doi: 10.1111/bjh.14378
– volume: 14
  start-page: 1902
  year: 2004
  ident: ref=120
  publication-title: Genome Res
  doi: 10.1101/gr.2722704
– volume: 2
  start-page: 1722
  year: 2012
  ident: ref=31
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2012.11.003
– volume: 100
  start-page: 417
  year: 2014
  ident: ref=85
  publication-title: Int J Hematol
  doi: 10.1007/s12185-014-1568-0
– volume: 110
  start-page: 1933
  year: 2007
  ident: ref=84
  publication-title: Blood
  doi: 10.1182/blood-2006-09-048322
– volume: 282
  start-page: 1145
  year: 1998
  ident: ref=9
  publication-title: Science
  doi: 10.1126/science.282.5391.1145
– volume: 30
  start-page: 2021
  year: 2016
  ident: ref=145
  publication-title: Genes Dev
  doi: 10.1101/gad.284109.116
– volume: 2
  start-page: 390
  year: 2018
  ident: ref=55
  publication-title: Blood Adv
  doi: 10.1182/bloodadvances.2017013342
– volume: 30
  start-page: 379
  year: 2012
  ident: ref=63
  publication-title: Stem Cells
  doi: 10.1002/stem.1036
– volume: 22
  start-page: 1503
  year: 2008
  ident: ref=67
  publication-title: Leukemia
  doi: 10.1038/leu.2008.141
– volume: 96
  start-page: 1591
  year: 2000
  ident: ref=135
  publication-title: Blood
  doi: 10.1182/blood.V96.4.1591
– volume: 119
  start-page: 388
  year: 2012
  ident: ref=39
  publication-title: Blood
  doi: 10.1182/blood-2011-03-341081
– volume: 40
  start-page: 49
  year: 2019
  ident: ref=5
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2018.11.005
– volume: 36
  start-page: 667
  year: 2009
  ident: ref=93
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2009.11.001
– volume: 34
  start-page: 1513
  year: 2016
  ident: ref=54
  publication-title: Stem Cells
  doi: 10.1002/stem.2332
– volume: 32
  start-page: 554
  year: 2014
  ident: ref=30
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.2915
– volume: 10
  year: 2015
  ident: ref=97
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0142400
– volume: 119
  start-page: 377
  year: 2012
  ident: ref=122
  publication-title: Blood
  doi: 10.1182/blood-2011-01-331686
– volume: 13
  start-page: 755
  year: 2007
  ident: ref=137
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2007.11.006
– volume: 121
  start-page: 2882
  year: 2013
  ident: ref=34
  publication-title: Blood
  doi: 10.1182/blood-2012-08-451641
– volume: 36
  start-page: 227
  year: 2009
  ident: ref=74
  publication-title: Mol Biol Rep
  doi: 10.1007/s11033-007-9171-6
– volume: 26
  start-page: 6697
  year: 2007
  ident: ref=143
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1210755
– volume: 135
  start-page: 2969
  year: 2008
  ident: ref=136
  publication-title: Development
  doi: 10.1242/dev.021121
– volume: 238
  start-page: 110
  year: 2010
  ident: ref=87
  publication-title: Immunol Rev
  doi: 10.1111/j.1600-065X.2010.00954.x
– volume: 129
  start-page: 2051
  year: 2017
  ident: ref=113
  publication-title: Blood
  doi: 10.1182/blood-2016-12-754051
– volume: 111
  start-page: 485
  year: 2008
  ident: ref=130
  publication-title: Blood
  doi: 10.1182/blood-2007-03-079681
– volume: 24
  start-page: 212
  year: 2017
  ident: ref=79
  publication-title: Cell Death Differ
  doi: 10.1038/cdd.2016.111
– volume: 31
  start-page: 351
  year: 2012
  ident: ref=104
  publication-title: EMBO J
  doi: 10.1038/emboj.2011.390
– volume: 24
  start-page: 2354
  year: 2005
  ident: ref=112
  publication-title: EMBO J
  doi: 10.1038/sj.emboj.7600702
– volume: 13
  start-page: 515
  ident: ref=156
  publication-title: Stem Cell Reports
  doi: 10.1016/j.stemcr.2019.07.009
– volume: 38
  start-page: 27
  year: 2006
  ident: ref=109
  publication-title: Nat Genet
  doi: 10.1038/ng1679
– volume: 119
  start-page: e139
  year: 2012
  ident: ref=65
  publication-title: Blood
  doi: 10.1182/blood-2011-12-396754
– volume: 134
  start-page: 393
  year: 2007
  ident: ref=86
  publication-title: Development
  doi: 10.1242/dev.02731
– volume: 2017
  year: 2017
  ident: ref=13
  publication-title: Stem Cells Int
  doi: 10.1155/2017/1286246
– volume: 5
  start-page: 4372
  year: 2014
  ident: ref=33
  publication-title: Nat Commun
  doi: 10.1038/ncomms5372
– volume: 24
  start-page: 1082
  year: 2015
  ident: ref=28
  publication-title: Stem Cells Dev
  doi: 10.1089/scd.2014.0318
– volume: 24
  start-page: 6824
  year: 2004
  ident: ref=98
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.24.15.6824-6836.2004
– volume: 7
  start-page: 583
  year: 2015
  ident: ref=66
  publication-title: World J Stem Cells
  doi: 10.4252/wjsc.v7.i3.583
– volume: 13
  year: 2017
  ident: ref=128
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1006887
– volume: 286
  start-page: 3250
  year: 2011
  ident: ref=59
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M110.157545
– volume: 125
  start-page: 3306
  year: 2015
  ident: ref=92
  publication-title: Blood
  doi: 10.1182/blood-2014-11-612465
– volume: 199
  start-page: 887
  year: 2015
  ident: ref=3
  publication-title: Genetics
  doi: 10.1534/genetics.114.173492
– volume: 113
  start-page: 505
  year: 2009
  ident: ref=126
  publication-title: Blood
  doi: 10.1182/blood-2008-01-136218
– volume: 118
  start-page: 218
  year: 2011
  ident: ref=14
  publication-title: Blood
  doi: 10.1182/blood-2011-05-352518
– volume: 113
  start-page: 2526
  year: 2009
  ident: ref=81
  publication-title: Blood
  doi: 10.1182/blood-2008-06-162164
– volume: 102
  start-page: 18081
  year: 2005
  ident: ref=131
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0506216102
– volume: 94
  start-page: 984
  year: 2009
  ident: ref=75
  publication-title: Haematologica
  doi: 10.3324/haematol.2008.002436
– volume: 2018
  year: 2018
  ident: ref=80
  publication-title: Stem Cells Int
  doi: 10.1155/2018/3569493
– volume: 108
  start-page: 3736
  year: 2006
  ident: ref=103
  publication-title: Blood
  doi: 10.1182/blood-2006-07-032847
– volume: 121
  start-page: 1255
  year: 2013
  ident: ref=48
  publication-title: Blood
  doi: 10.1182/blood-2012-06-434407
– volume: 19
  start-page: 341
  year: 2016
  ident: ref=149
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2016.06.019
– volume: 5
  start-page: 85
  year: 2014
  ident: ref=21
  publication-title: Stem Cell Res Ther
  doi: 10.1186/scrt474
– volume: 20
  start-page: 1443
  year: 2012
  ident: ref=35
  publication-title: Mol Ther
  doi: 10.1038/mt.2012.49
– volume: 122
  start-page: 3705
  year: 2012
  ident: ref=91
  publication-title: J Clin Invest
  doi: 10.1172/JCI61619
– volume: 25
  start-page: 2821
  year: 2018
  ident: ref=116
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2018.11.032
– volume: 92
  start-page: 1619
  year: 2012
  ident: ref=132
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00046.2011
– volume: 511
  start-page: 312
  year: 2014
  ident: ref=37
  publication-title: Nature
  doi: 10.1038/nature13547
– volume: 202
  start-page: 770
  year: 2019
  ident: ref=26
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1801027
– volume: 62
  start-page: 847
  year: 2018
  ident: ref=56
  publication-title: Int J Dev Biol
  doi: 10.1387/ijdb.180206at
– volume: 40
  start-page: 5819
  year: 2012
  ident: ref=45
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gks281
– volume: 129
  start-page: 2092
  year: 2017
  ident: ref=101
  publication-title: Blood
  doi: 10.1182/blood-2016-09-687871
– volume: 101
  start-page: 980
  year: 2004
  ident: ref=100
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0307612100
– volume: 126
  start-page: 663
  year: 2006
  ident: ref=10
  publication-title: Cell
  doi: 10.1016/j.cell.2006.07.024
– volume: 176
  start-page: 2924
  year: 2006
  ident: ref=24
  publication-title: J Immunol
  doi: 10.4049/jimmunol.176.5.2924
– volume: 44
  start-page: 457
  year: 2012
  ident: ref=118
  publication-title: Int J Biochem Cell Biol
  doi: 10.1016/j.biocel.2011.12.004
– volume: 41
  start-page: 971
  year: 2018
  ident: ref=133
  publication-title: Mol Cells
– volume: 24
  start-page: 1249
  year: 2010
  ident: ref=110
  publication-title: Leukemia
  doi: 10.1038/leu.2010.104
– year: 2019
  ident: ref=51
  publication-title: Cell Stem Cell
– volume: 140
  start-page: 2463
  year: 2013
  ident: ref=2
  publication-title: Development
  doi: 10.1242/dev.083147
– volume: 155
  start-page: 215
  year: 2013
  ident: ref=142
  publication-title: Cell
  doi: 10.1016/j.cell.2013.08.055
– volume: 118
  start-page: 163
  year: 2016
  ident: ref=115
  publication-title: Curr Top Dev Biol
  doi: 10.1016/bs.ctdb.2016.01.004
– volume: 44
  start-page: 887
  year: 2016
  ident: ref=19
  publication-title: Exp Hematol
  doi: 10.1016/j.exphem.2016.06.005
– volume: 18
  start-page: 180
  year: 2017
  ident: ref=42
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg.2016.156
– volume: 89
  start-page: 1922
  year: 1997
  ident: ref=68
  publication-title: Blood
  doi: 10.1182/blood.V89.6.1922
– volume: 100
  start-page: 8811
  year: 2003
  ident: ref=94
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1432147100
– volume: 545
  start-page: 439
  year: 2017
  ident: ref=38
  publication-title: Nature
  doi: 10.1038/nature22326
– volume: 42
  start-page: 442
  year: 2014
  ident: ref=129
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkt848
– volume: 15
  start-page: 31
  year: 2014
  ident: ref=154
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2014.06.016
– volume: 12
  start-page: 124
  year: 2017
  ident: ref=12
  publication-title: Curr Stem Cell Res Ther
  doi: 10.2174/1574888X10666151026114241
– volume: 28
  start-page: 858
  year: 2000
  ident: ref=16
  publication-title: Exp Hematol
  doi: 10.1016/S0301-472X(00)00169-7
– volume: 113
  start-page: 4720
  year: 2009
  ident: ref=125
  publication-title: Blood
  doi: 10.1182/blood-2008-11-190215
– volume: 121
  start-page: 163
  year: 1995
  ident: ref=88
  publication-title: Development
  doi: 10.1242/dev.121.1.163
– volume: 47
  year: 2019
  ident: ref=151
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkz267
– volume: 13
  start-page: 459
  year: 2013
  ident: ref=32
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.09.002
– volume: 107
  start-page: 14229
  year: 2010
  ident: ref=15
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0913574107
– volume: 121
  start-page: 2440
  year: 2013
  ident: ref=117
  publication-title: Blood
  doi: 10.1182/blood-2012-08-450627
– volume: 48
  start-page: 1814
  year: 2016
  ident: ref=18
  publication-title: Transplant Proc
  doi: 10.1016/j.transproceed.2016.03.014
– volume: 2
  start-page: 60
  year: 2008
  ident: ref=139
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2007.10.011
– volume: 26
  start-page: 650
  year: 2017
  ident: ref=140
  publication-title: Protein Sci
  doi: 10.1002/pro.3122
– volume: 111
  start-page: 5298
  year: 2008
  ident: ref=29
  publication-title: Blood
  doi: 10.1182/blood-2007-10-117622
– volume: 49
  start-page: 80
  year: 2013
  ident: ref=148
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2012.10.008
– volume: 106
  start-page: 3988
  year: 2005
  ident: ref=40
  publication-title: Blood
  doi: 10.1182/blood-2005-05-2003
– volume: 2
  start-page: 72
  year: 2008
  ident: ref=138
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2007.10.022
– volume: 7
  start-page: 1388
  year: 2015
  ident: ref=22
  publication-title: EMBO Mol Med
  doi: 10.15252/emmm.201505301
– volume: 117
  start-page: e142
  year: 2011
  ident: ref=64
  publication-title: Blood
  doi: 10.1182/blood-2010-12-323212
– volume: 59
  start-page: 431
  year: 2011
  ident: ref=105
  publication-title: Arch Immunol Ther Exp (Warsz)
  doi: 10.1007/s00005-011-0147-9
– volume: 18
  start-page: 595
  year: 2016
  ident: ref=71
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb3354
– volume: 472
  start-page: 120
  year: 2011
  ident: ref=82
  publication-title: Nature
  doi: 10.1038/nature09819
– volume: 7
  start-page: 532
  year: 2010
  ident: ref=99
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2010.07.016
– volume: 115
  start-page: 2180
  year: 2018
  ident: ref=52
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1718446115
– volume: 5
  start-page: 4330
  year: 2014
  ident: ref=155
  publication-title: Nat Commun
  doi: 10.1038/ncomms5330
SSID ssj0020870
Score 2.301659
SecondaryResourceType review_article
Snippet Numerous human disorders of the blood system would directly or indirectly benefit from therapeutic approaches that reconstitute the hematopoietic system....
SourceID pubmedcentral
proquest
pubmed
crossref
benthamscience
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 438
SubjectTerms Autografts
Blood
Cell culture
Cell differentiation
Cell therapy
Current Genomics
Disorders
Engraftment
Gene regulation
Hematological diseases
Hematopoiesis
Hematopoietic stem cells
Hematopoietic system
Homeobox
miRNA
Molecular modelling
Pluripotency
Regenerative medicine
Stem cell transplantation
Stem cells
Tissue engineering
Transcription factors
Title Hematopoietic Differentiation of Human Pluripotent Stem Cells: HOX and GATA Transcription Factors as Master Regulators
URI http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1389-2029&volume=20&issue=6&spage=438
https://www.ncbi.nlm.nih.gov/pubmed/32194342
https://www.proquest.com/docview/2334371474
https://www.proquest.com/docview/2381620304
https://pubmed.ncbi.nlm.nih.gov/PMC7062042
Volume 20
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1tb9MwELbKEAgkEO8UBvIkvlVheWua8q2a1lXQbQhaqd8sJ3HUjjYpTUo1JH4Vf5A7281LYWjwJYry4li5x-c7--45Qt6YnolLC8KAucszYCQ6RhBZkRFbbqcjfDeOIlzvOD3zBmP3_aQ9aTR-VqKW1nnwNvz-x7yS_5EqXAO5YpbsP0i2aBQuwDnIF44gYTheS8YDJFxNl-kMMxFBe6laJ_msMAPVEv3H-RpUQ5rjtv_nXCxaR2I-l6Fwg_OJ3D046Y16iue8UCJ9XYiHZ61TjmwKIAlZtj7V-z8XddpSJHtdVELne_OMXwq1g_NhCtNQVGx3YPF6uT-fGbhPpLLShik0w8uY2098kcJ96N36gsv64K0TTJaO0nLxNVrx2Vc1eQa8un5hlQFaepFOJFO-KDRZmQxQUcoORmKZemVEqGvgZxngbflVTW6bFcRW1bKrGGR2pwt0x3DlAtrH5pHZHvxJS1IIoedezpHbuICzc9YfD4dsdDwZ3SA3bfBNZIb5pIgrsk2_o1LTdadvkwP9qcMrP3SX3AtAVPAjtN1Tt5J-c312I3grJtHoAbmvfRnaU8B8SBoieURuqeqml4_Jtxo86Q48aRpTCU9agSdFeFIJz3cUwElB_BTBSWvgpBqclGdUgZOW4HxCxv3j0dHA0GU-jACc3dwAB9jH_PDQEpZwuR-EsWXHnnDbdmwiS63w212z64gQqaUix-ZgJIfomdhhGMah85TsJWkinhMK0gjbYPLGXcFdHnq-KQSSLoJUkLbIbZIf9f_MlorTRWa3sc1mw8R6Jb7wTBahYqAamK5ixzB1BAtfL6dLJsc90-OeISAZypahcJkCI5wzCUTmMQlCBiBsEn8rVhZqDn4sBTNn4IsjRNiVEGkSu3h12-lrvLS_xQ7TeitjtuO4yNPZgd9xUNyGWQW3Cnki0jU-41uejWETTfJMQa34qgNGjuu4dpN0aiAsHkDG-vqdZDaVzPUdE8tf2C_-3q2X5E6pKPbJXr5ai1dg-ufBaznUfgFmugWF
linkProvider Geneva Foundation for Medical Education and Research
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Hematopoietic+Differentiation+of+Human+Pluripotent+Stem+Cells%3A+HOX+and+GATA+Transcription+Factors+as+Master+Regulators&rft.jtitle=Current+genomics&rft.au=Alsayegh%2C+Khaled&rft.au=Cort%C3%A9s-Medina%2C+Lorena+V&rft.au=Ramos-Mandujano%2C+Gerardo&rft.au=Badraiq%2C+Heba&rft.date=2019-09-01&rft.pub=Benham+Science+Publishers&rft.issn=1389-2029&rft.eissn=1875-5488&rft.volume=20&rft.issue=6&rft.spage=438&rft_id=info:doi/10.2174%2F1389202920666191017163837&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1389-2029&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1389-2029&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1389-2029&client=summon