Agent-based dynamic knowledge representation of Pseudomonas aeruginosa virulence activation in the stressed gut: Towards characterizing host-pathogen interactions in gut-derived sepsis

• Published in: Theoretical biology and medical modelling Vol. 8; no. 1; p. 33
• Main Authors: Seal, John B, Alverdy, John C, Zaborina, Olga, An, Gary
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.09.2011; BioMed Central
• Subjects: Animals; Behavior; Complications and side effects; Computer Simulation; Design of experiments; Disease; Gastrointestinal Tract - microbiology; Gastrointestinal Tract - pathology; Genetic aspects; Host-Pathogen Interactions; Humans; Infections; Intestines - blood supply; Intestines - pathology; Ischemia - complications; Ischemia - pathology; Mathematical models; Metabolism; Mice; Models, Biological; Mortality; Nosocomial infections; Pathogenesis; Phosphates - deficiency; Pseudomonas aeruginosa - pathogenicity; Pseudomonas aeruginosa infections; Risk factors; Sepsis; Sepsis - complications; Sepsis - microbiology; Sepsis - pathology; Software; Stress, Physiological; Studies; Virulence; Virulence (Microbiology); United States

There is a growing realization that alterations in host-pathogen interactions (HPI) can generate disease phenotypes without pathogen invasion. The gut represents a prime region where such HPI can arise and manifest. Under normal conditions intestinal microbial communities maintain a stable, mutually...