Claudin-1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study

• Published in: Breast cancer research : BCR Vol. 7; no. 2; pp. R296 - R305
• Main Authors: Tokés, Anna-Mária, Kulka, Janina, Paku, Sándor, Szik, Agnes, Páska, Csilla, Novák, Pál Kaposi, Szilák, László, Kiss, András, Bögi, Krisztina, Schaff, Zsuzsa
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.01.2005; National Library of Medicine - MEDLINE Abstracts; BioMed Central
• Subjects: Adult; Aged; Aged, 80 and over; Analysis; Breast Diseases - genetics; Breast Neoplasms - genetics; Cell Differentiation; Claudin-1; Claudin-3; Claudin-4; Female; Genes; Humans; Immunohistochemistry; Membrane Proteins - biosynthesis; Membrane Proteins - physiology; Messenger RNA; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Polymerase Chain Reaction; RNA, Messenger - analysis; RNA, Messenger - biosynthesis; Tight Junctions

We compared levels of protein and mRNA expression of three members of the claudin (CLDN) family in malignant breast tumours and benign lesions. Altogether, 56 sections from 52 surgically resected breast specimens were analyzed for CLDN1, CLDN3 and CLDN4 expression by immunohistochemistry. mRNA was a...