Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice

• Published in: Gut Vol. 45; no. 6; pp. 864 - 873
• Main Authors: McCafferty, D-M, Miampamba, M, Sihota, E, Sharkey, K A, Kubes, P
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.12.1999; BMJ; BMJ Publishing Group LTD
• Subjects: Acute Disease; Animals; Biological and medical sciences; Biopsy; Chronic Disease; Colitis - chemically induced; Colitis - enzymology; Crohns disease; Deoxyribonucleic acid; DNA; epithelial permeability; Female; Fluorescent Antibody Technique; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression; Inflammation; Inflammatory bowel disease; Laboratories; Male; Medical research; Medical sciences; Mice; Mice, Mutant Strains; Neutrophils; Neutrophils - enzymology; Nitric oxide; nitric oxide synthase; Nitric Oxide Synthase - deficiency; Nitric Oxide Synthase - genetics; Nitric Oxide Synthase - physiology; Nitric Oxide Synthase Type II; Other diseases. Semiology; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Rodents; Stem cells; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Studies; Trinitrobenzenesulfonic Acid; New Jersey; Enzyme; Induction; Leukocyte; Pathogenesis; Rodentia; Nitric-oxide synthase; Vertebrata; Experimental disease; Mammalia; Mouse; Animal; Digestive diseases; Intestinal disease; Oxidoreductases; Colitis

BACKGROUND Studies using inhibitors of nitric oxide synthase (NOS) to date are inconclusive regarding the role of inducible NOS (iNOS) in intestinal inflammation. AIMS (1) To examine the role of iNOS in the development of chronic intestinal inflammation; (2) to identify the cellular source(s) of iNO...