Screening for an ivermectin slow-release formulation suitable for malaria vector control

• Published in: Malaria journal Vol. 14; no. 1; p. 102
• Main Authors: Chaccour, Carlos, Barrio, Ángel Irigoyen, Royo, Ana Gloria Gil, Urbistondo, Diego Martinez, Slater, Hannah, Hammann, Felix, Del Pozo, Jose Luis
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.03.2015; BioMed Central
• Subjects: Analysis; Animals; Anopheles; Anopheles - drug effects; Antihelmintics; Antihelmíntics; Control; Delayed-Action Preparations - administration & dosage; Delayed-Action Preparations - pharmacokinetics; Delayed-Action Preparations - pharmacology; Delayed-Action Preparations - toxicity; Drug Implants; Health aspects; Insect Vectors - drug effects; Insectes vectors; Insecticides - administration & dosage; Insecticides - pharmacokinetics; Insecticides - pharmacology; Insecticides - toxicity; Insects as carriers of disease; Ivermectin - administration & dosage; Ivermectin - pharmacokinetics; Ivermectin - pharmacology; Ivermectin - toxicity; Malaria; Malaria - prevention & control; Malaria - transmission; Male; Malària; Medicina preventiva; Pesticide resistance; Preventive medicine; Rabbits; Silicones

The prospect of eliminating malaria is challenged by emerging insecticide resistance and vectors with outdoor and/or crepuscular activity. Ivermectin can simultaneously tackle these issues by killing mosquitoes feeding on treated animals and humans. A single oral dose, however, confers only short-li...