Nitric oxide modulation of the basal ganglia circuitry: therapeutic implication for Parkinson's disease and other motor disorders

• Published in: CNS & neurological disorders drug targets Vol. 10; no. 7; p. 777
• Main Authors: Pierucci, Massimo, Galati, Salvatore, Valentino, Mario, Di Matteo, Vincenzo, Benigno, Arcangelo, Pitruzzella, Alessandro, Muscat, Richard, Di Giovanni, Giuseppe
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.11.2011
• Subjects: Animals; Basal Ganglia - drug effects; Basal Ganglia - metabolism; Basal Ganglia - physiology; Basal Ganglia Diseases - drug therapy; Basal Ganglia Diseases - metabolism; Humans; Movement Disorders - drug therapy; Movement Disorders - metabolism; Nerve Net - drug effects; Nerve Net - metabolism; Nitric Oxide - physiology; Parkinson Disease - drug therapy; Parkinson Disease - metabolism

Several recent studies have emphasized a crucial role for the nitrergic system in movement control and the pathophysiology of the basal ganglia (BG). These observations are supported by anatomical evidence demonstrating the presence of nitric oxide synthase (NOS) in all the basal ganglia nuclei. In...