Pathobiology of liver fibrosis: a translational success story

• Published in: Gut Vol. 64; no. 5; pp. 830 - 841
• Main Authors: Lee, Youngmin A, Wallace, Michael C, Friedman, Scott L
• Format: Journal Article Book Review
• Language: English
• Published: England BMJ Publishing Group LTD 01.05.2015
• Subjects: Chronic illnesses; Clinical trials; Clinical Trials as Topic - methods; Drug Discovery - methods; Family medical history; Fibroblasts; Gastrointestinal surgery; Growth factors; Hepatic Stellate Cells - physiology; Hepatitis; Hepatitis B virus; Humans; Liver cancer; Liver cirrhosis; Liver Cirrhosis - drug therapy; Liver Cirrhosis - pathology; Liver diseases; Mortality; Patient Selection; Rodents; Stem cells; Translational Medical Research - methods; FATTY LIVER; EXTRACELLULAR MATRIX; HEPATIC STELLATE CELL; CIRRHOSIS; HEPATIC FIBROSIS

Reversibility of hepatic fibrosis and cirrhosis following antiviral therapy for hepatitis B or C has advanced the prospect of developing antifibrotic therapies for patients with chronic liver diseases, especially non-alcoholic steatohepatitis. Mechanisms of fibrosis have focused on hepatic stellate...