Mesenteric fat as a source of C reactive protein and as a target for bacterial translocation in Crohn's disease

• Published in: Gut Vol. 61; no. 1; pp. 78 - 85
• Main Authors: Peyrin-Biroulet, Laurent, Gonzalez, Florent, Dubuquoy, Laurent, Rousseaux, Christel, Dubuquoy, Caroline, Decourcelle, Cécilia, Saudemont, Alain, Tachon, Mickael, Béclin, Elodie, Odou, Marie-Françoise, Neut, Christel, Colombel, Jean-Frédéric, Desreumaux, Pierre
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.01.2012; BMJ Publishing Group; BMJ Publishing Group LTD; BMJ Group
• Series: Original article
• Subjects: 6-mercaptopurine; 6-trinitrobenzene sulfonic acid; Abdominal Fat - metabolism; Abdominal Fat - microbiology; acute hepatitis; Adipocytes; Adult; alcoholic liver disease; Animals; anti-bacterial mucosal immunity; anti-bacterial peptide; antibacterial peptide; antibiotic therapy; antibiotics: clinical trials; azathioprine; bacteraemia; Bacteria; bacterial adherence; bacterial infection; bacterial overgrowth; bacterial pathogenesis; Bacterial Translocation; Biological and medical sciences; Biopsy; Biosynthesis; Body mass index; C Reactive protein; C-Reactive Protein - metabolism; cell biology; Cell Line; Colitis, Ulcerative - metabolism; Colitis, Ulcerative - microbiology; Crohn Disease - metabolism; Crohn Disease - microbiology; Crohn's disease; Crohns disease; Cytokines; Escherichia coli; Escherichia coli - metabolism; Escherichia coli - physiology; Female; gastric neoplasia; Gastroenterology. Liver. Pancreas. Abdomen; genetic polymorphisms; Genotype & phenotype; Gram-negative bacteria; gut inflammation; Helicobacter pylori; Humans; IBD; IBD basic research; IBD clinical; IBD models; Ileitis - metabolism; Ileitis - microbiology; Inflammation; Inflammatory Bowel Disease; Interleukin-6 - metabolism; Lipopolysaccharides - metabolism; Lymph Nodes - microbiology; Lymphatic system; Male; Medical sciences; mesenteric fat; Mesentery - metabolism; Mesentery - microbiology; Mice; mucosal immunology; non-alcoholic steatohepatitis; non-ulcer dyspepsia; Other diseases. Semiology; Prospective Studies; Proteins; Rodents; small intestine; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Streptococcus infections; Studies; Surgery; thiopurine methyltransferase; TNF-alpha; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; ulcerative colitis; Infection; Translocation; Crohn disease; Gastroenterology; Bacteriosis; Fat; Digestive diseases; Intestinal disease; Mesentery; C reactive protein; Inflammatory disease

ObjectiveMesenteric fat hyperplasia is a hallmark of Crohn's disease (CD), and C reactive protein (CRP) is correlated with disease activity. The authors investigated whether mesenteric adipocytes may be a source of CRP in CD and whether inflammatory and bacterial triggers may stimulate its prod...