Lipoxygenase: an emerging target for stroke therapy
Neuroprotection as approach to stroke therapy has recently seen a revival of sorts, fueled in part by the continuing necessity to improve acute stroke care, and in part by the identification of novel drug targets. 12/15- Lipoxygenase (12/15-LOX), one of the key enzymes of the arachidonic acid cascad...
Saved in:
| Published in | CNS & neurological disorders drug targets Vol. 12; no. 2; p. 191 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United Arab Emirates
01.03.2013
|
| Subjects | |
| Online Access | Get more information |
| ISSN | 1996-3181 |
| DOI | 10.2174/18715273112119990053 |
Cover
Loading…
| Abstract | Neuroprotection as approach to stroke therapy has recently seen a revival of sorts, fueled in part by the continuing necessity to improve acute stroke care, and in part by the identification of novel drug targets. 12/15- Lipoxygenase (12/15-LOX), one of the key enzymes of the arachidonic acid cascade, contributes to both neuronal cell death and vascular injury. Inhibition of 12/15-LOX may thus provide multifactorial protection against ischemic injury. Targeting 12/15-LOX and related eicosanoid pathways is the subject of this brief review. |
|---|---|
| AbstractList | Neuroprotection as approach to stroke therapy has recently seen a revival of sorts, fueled in part by the continuing necessity to improve acute stroke care, and in part by the identification of novel drug targets. 12/15- Lipoxygenase (12/15-LOX), one of the key enzymes of the arachidonic acid cascade, contributes to both neuronal cell death and vascular injury. Inhibition of 12/15-LOX may thus provide multifactorial protection against ischemic injury. Targeting 12/15-LOX and related eicosanoid pathways is the subject of this brief review. |
| Author | van Leyen, Klaus |
| Author_xml | – sequence: 1 givenname: Klaus surname: van Leyen fullname: van Leyen, Klaus email: klaus_vanleyen@hms.harvard.edu organization: Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, 149 13th St., R. 2401, Charlestown, MA 02129, USA. klaus_vanleyen@hms.harvard.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23394536$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1jstKxTAURYMo3of-gUh-oJqT07ycycUXFJzo-JImp7Vq05JWsH_vBXW012Cx2Bt2nIZEjF2AuJJgymuwBpQ0CCABnHNCKDxi6wPqAsHCim2m6V2IUiOYU7aSiK5UqNcMq24cvpeWkp_ohvvEqafcdqnls88tzbwZMp_mPHwQn98o-3E5YyeN_5zo_G-37PX-7mX3WFTPD0-726qolVZzEQVYFzXIEGIsPdZOS0MeyQo0FEOtQIXSBRISGq0D1Q3oSDZY7yMe5C27_O2OX3VPcT_mrvd52f-_lz_eXUfs |
| CitedBy_id | crossref_primary_10_1007_s00011_023_01770_8 crossref_primary_10_1007_s12975_016_0509_z crossref_primary_10_1080_00207454_2019_1645142 crossref_primary_10_1038_s41598_020_69831_0 crossref_primary_10_1021_acs_jmedchem_8b01987 crossref_primary_10_3390_jcm6020022 crossref_primary_10_1080_26395940_2023_2292104 crossref_primary_10_31857_S1234567824080111 crossref_primary_10_1016_j_expneurol_2018_11_010 crossref_primary_10_1159_000350230 crossref_primary_10_1002_anie_202418291 crossref_primary_10_1016_j_bmc_2016_08_063 crossref_primary_10_1021_acsomega_7b01622 crossref_primary_10_1248_bpb_b23_00793 crossref_primary_10_1016_j_neuroscience_2017_07_015 crossref_primary_10_1002_chem_202402279 crossref_primary_10_1016_j_arres_2021_100023 crossref_primary_10_1016_j_ejmech_2016_07_010 crossref_primary_10_1002_bmc_5614 crossref_primary_10_3390_metabo11080498 crossref_primary_10_1134_S0021364024600460 crossref_primary_10_1016_j_bbalip_2016_11_008 crossref_primary_10_1080_14728222_2024_2446319 crossref_primary_10_2319_103123_730_1 crossref_primary_10_1016_j_jff_2022_105197 crossref_primary_10_1002_anie_201606876 crossref_primary_10_1038_jcbfm_2015_169 crossref_primary_10_1016_j_bioorg_2019_01_071 crossref_primary_10_1016_j_bbalip_2014_10_002 crossref_primary_10_1016_j_bmc_2016_01_042 crossref_primary_10_1016_j_jmgm_2015_12_001 crossref_primary_10_1016_j_redox_2015_08_006 crossref_primary_10_1021_jm401915r crossref_primary_10_1080_1028415X_2017_1347373 crossref_primary_10_1002_ange_201606876 crossref_primary_10_1002_ange_202418291 crossref_primary_10_1016_j_gene_2015_07_073 crossref_primary_10_1016_j_biopha_2020_110151 crossref_primary_10_3390_molecules23071621 crossref_primary_10_1111_jnc_15308 crossref_primary_10_1161_STROKEAHA_116_014790 crossref_primary_10_1248_yakushi_23_00207 crossref_primary_10_3390_molecules26165001 crossref_primary_10_3389_fneur_2022_821082 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM |
| DOI | 10.2174/18715273112119990053 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1996-3181 |
| ExternalDocumentID | 23394536 |
| Genre | Journal Article Review Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NINDS NIH HHS grantid: R01 NS069939 – fundername: NINDS NIH HHS grantid: R01 NS049430 – fundername: NINDS NIH HHS grantid: R01NS069939 – fundername: NINDS NIH HHS grantid: R01NS049430 |
| GroupedDBID | --- .5. 0R~ 29B 36B 4.4 5GY AAEGP ABEEF ABVDF ACGFS ACITR AFUQM AGJNZ ALMA_UNASSIGNED_HOLDINGS ANTIV C1A CGR CS3 CUY CVF EBS ECM EIF EJD F5P GH2 HZ~ IPNFZ KCGFV NPM O9- RIG |
| ID | FETCH-LOGICAL-b565t-d0189d612ccdd4a3b9627ea3e8037edcb515c49ce021f66cebf16de8c8aad3962 |
| IngestDate | Thu May 23 23:18:31 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-b565t-d0189d612ccdd4a3b9627ea3e8037edcb515c49ce021f66cebf16de8c8aad3962 |
| OpenAccessLink | http://www.eurekaselect.com/article/50425 |
| PMID | 23394536 |
| ParticipantIDs | pubmed_primary_23394536 |
| PublicationCentury | 2000 |
| PublicationDate | 2013-03-01 |
| PublicationDateYYYYMMDD | 2013-03-01 |
| PublicationDate_xml | – month: 03 year: 2013 text: 2013-03-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United Arab Emirates |
| PublicationPlace_xml | – name: United Arab Emirates |
| PublicationTitle | CNS & neurological disorders drug targets |
| PublicationTitleAlternate | CNS Neurol Disord Drug Targets |
| PublicationYear | 2013 |
| References | 21353711 - Trends Neurosci. 2011 Apr;34(4):198-209 12395100 - Neuroreport. 2002 Oct 28;13(15):1963-6 18840431 - Exp Eye Res. 2009 Feb;88(2):133-9 18309145 - Stroke. 2008 Apr;39(4):1389-91 12521597 - Free Radic Biol Med. 2003 Jan 15;34(2):145-69 19091170 - Curr Cardiol Rep. 2009 Jan;11(1):12-20 18323512 - Stroke. 2008 Apr;39(4):1109-14 19853588 - Brain Res. 2010 Jan 11;1307:149-57 16443152 - Free Radic Biol Med. 2006 Feb 1;40(3):376-87 9759730 - Nature. 1998 Sep 24;395(6700):392-5 17942241 - Neuroscience. 2007 Dec 12;150(3):585-91 16282974 - Nat Genet. 2006 Jan;38(1):68-74 20689558 - Cell Death Differ. 2011 Feb;18(2):282-92 20670828 - Neuron. 2010 Jul 29;67(2):181-98 17960827 - J Neurosci Res. 2008 Mar;86(4):904-9 10657944 - Am J Respir Cell Mol Biol. 2000 Feb;22(2):226-34 20138164 - Brain Res. 2010 Apr 6;1323:174-83 9854309 - Trends Cell Biol. 1998 Nov;8(11):436 15686484 - J Neurochem. 2005 Feb;92(4):824-30 17687131 - N Engl J Med. 2007 Aug 9;357(6):562-71 16500106 - Bioorg Med Chem. 2006 Jun 15;14(12):4295-301 21957234 - J Neurosci. 2011 Sep 28;31(39):13710-21 11740205 - J Cereb Blood Flow Metab. 2001 Dec;21(12):1436-41 15853750 - Curr Drug Targets Cardiovasc Haematol Disord. 2005 Apr;5(2):177-84 12125346 - Methods Enzymol. 2002;352:183-90 23192915 - Ann Neurol. 2013 Jan;73(1):129-35 9445321 - Stroke. 1998 Jan;29(1):12-7 16005201 - Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct;73(3-4):141-62 15033436 - Brain Res. 2004 Apr 9;1004(1-2):198-202 20801095 - Arch Biochem Biophys. 2010 Nov 15;503(2):161-74 10446122 - J Biol Chem. 1999 Aug 20;274(34):23679-82 14770184 - Nat Genet. 2004 Mar;36(3):233-9 18233953 - Annu Rev Pathol. 2008;3:279-312 12194501 - Neuroscientist. 2002 Aug;8(4):323-34 20357438 - Cerebrovasc Dis. 2010;29(6):528-37 15487674 - Sci Am. 2004 Oct;291(4):82-9 10560610 - Prostaglandins Other Lipid Mediat. 1999 Oct;58(2-4):65-75 11231012 - FEBS Lett. 2001 Jan 26;489(1):51-4 15086555 - J Invest Dermatol. 2004 Mar;122(3):691-8 18308347 - Neuropharmacology. 2008 Sep;55(3):363-89 15637312 - Stroke. 2005 Feb;36(2):182-5 21423332 - Transl Stroke Res. 2011 Mar;2(1):33-41 11158633 - Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1294-9 16923160 - J Neurochem. 2006 Sep;98(5):1474-86 18635843 - Stroke. 2008 Sep;39(9):2538-43 663662 - Science. 1978 Jul 28;201(4353):358-60 14672754 - Life Sci. 2004 Jan 9;74(8):969-85 17622306 - Mol Med. 2007 Jul-Aug;13(7-8):350-5 19737346 - J Neurochem. 2009 Nov;111(3):882-9 20059330 - Annu Rev Med. 2010;61:17-33 2180770 - FASEB J. 1990 Apr 1;4(6):1624-33 18384889 - Trends Pharmacol Sci. 2008 May;29(5):268-75 7903353 - J Neurochem. 1994 Jan;62(1):376-9 21719775 - Stroke. 2011 Aug;42(8):2308-14 18202310 - Stroke. 2008 Feb;39(2):521-2 15910986 - J Neurosci Methods. 2005 Jun 15;144(2):257-63 17826100 - Bioorg Med Chem. 2007 Nov 15;15(22):6900-8 21356152 - Expert Rev Mol Med. 2011;13:e7 18202309 - Stroke. 2008 Feb;39(2):523-4 9403693 - Nature. 1997 Dec 11;390(6660):622-5 22709986 - Neurobiol Dis. 2012 Oct;48(1):58-65 19542051 - Stroke. 2009 Sep;40(9):3121-6 17167069 - FASEB J. 2007 Mar;21(3):743-53 20068575 - J Cereb Blood Flow Metab. 2010 Jun;30(6):1157-67 6318 - FEBS Lett. 1975 Dec 1;60(1):149-52 21867913 - Chem Biol. 2011 Aug 26;18(8):976-87 14698463 - Neurosci Lett. 2004 Jan 9;354(2):163-5 20368741 - Nat Rev Neurol. 2010 May;6(5):256-65 12432925 - Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:303-12 9160751 - Cell. 1997 May 16;89(4):597-606 17053180 - Stroke. 2006 Dec;37(12):3014-8 6719118 - Science. 1984 May 25;224(4651):886-9 17272759 - Stroke. 2007 Mar;38(3):1063-8 15637315 - Stroke. 2005 Feb;36(2):189-92 21673716 - J Cereb Blood Flow Metab. 2011 Nov;31(11):2218-30 9414270 - Blood. 1998 Jan 1;91(1):64-74 22155783 - Mol Pharmacol. 2012 Mar;81(3):420-30 3087141 - Adv Enzymol Relat Areas Mol Biol. 1986;58:191-272 22700906 - Science. 2012 Jun 15;336(6087):1386-7 21427623 - J Trauma. 2011 Nov;71(5):1211-8 15180492 - Curr Drug Metab. 2004 Jun;5(3):225-34 15450084 - Eur J Neurosci. 2004 Oct;20(8):2049-58 5473492 - Biochim Biophys Acta. 1970 Oct 6;218(1):1-10 2834836 - Stroke. 1988 Apr;19(4):480-5 18549870 - Am J Cardiol. 2008 Jun 16;101(12A):34F-40F 12204769 - Life Sci. 2002 Sep 20;71(18):2105-17 20494126 - Biochem Biophys Res Commun. 2010 May 21;396(1):135-9 9473716 - Brain Res Mol Brain Res. 1998 Jan;53(1-2):333-8 11526430 - Cell Death Differ. 2001 Aug;8(8):776-84 10432118 - Nature. 1999 Jul 22;400(6742):378-82 21838667 - Cardiovasc Hematol Agents Med Chem. 2011 Jul 1;9(3):154-64 21620406 - Atherosclerosis. 2011 Sep;218(1):181-7 20640551 - Age (Dordr). 2010 Sep;32(3):271-82 8683259 - J Neurosurg. 1996 Jul;85(1):112-6 11498518 - Br J Pharmacol. 2001 Aug;133(8):1323-9 12909283 - Brain Res Bull. 2003 Aug 30;61(4):399-406 22074807 - Neurobiol Aging. 2012 Mar;33(3):629.e1-3 16480270 - J Med Chem. 2006 Feb 23;49(4):1356-63 22542947 - Exp Neurol. 2012 Jul;236(1):122-30 1720576 - Stroke. 1991 Dec;22(12):1548-53 11207368 - Cell. 2001 Jan 26;104(2):281-90 6309072 - Ann Neurol. 1983 Jun;13(6):625-32 12917400 - J Biol Chem. 2003 Oct 31;278(44):43508-15 20157789 - Mol Neurobiol. 2010 Jun;41(2-3):172-9 16453316 - Ann Neurol. 2006 Mar;59(3):467-77 18439837 - Pharmacol Res. 2008 Apr;57(4):266-73 19840779 - Brain Res. 2010 Jan 11;1307:22-7 20673332 - J Neuroinflammation. 2010;7:42 16834755 - CNS Drug Rev. 2006 Spring;12(1):9-20 19422397 - Br J Pharmacol. 2009 Oct;158(4):972-81 18202308 - Stroke. 2008 Feb;39(2):525 22356734 - Antioxid Redox Signal. 2012 Sep 1;17(5):719-32 9292733 - Neuron. 1997 Aug;19(2):453-63 20868723 - Biochimie. 2011 Jan;93(1):46-51 18545259 - J Cereb Blood Flow Metab. 2008 Oct;28(10):1686-96 16166580 - Stroke. 2005 Oct;36(10):2258-64 12923200 - J Biol Chem. 2003 Oct 31;278(44):43807-17 18762024 - Cell Metab. 2008 Sep;8(3):237-48 17261713 - Stroke. 2007 Feb;38(2 Suppl):674-6 17608719 - FEBS J. 2007 Jul;274(14):3503-12 21835339 - Neuron. 2011 Aug 11;71(3):406-24 20229265 - Pflugers Arch. 2010 Jul;460(2):525-42 19808012 - Prostaglandins Other Lipid Mediat. 2010 Apr;91(3-4):104-12 |
| References_xml | – reference: 6318 - FEBS Lett. 1975 Dec 1;60(1):149-52 – reference: 9759730 - Nature. 1998 Sep 24;395(6700):392-5 – reference: 22356734 - Antioxid Redox Signal. 2012 Sep 1;17(5):719-32 – reference: 1720576 - Stroke. 1991 Dec;22(12):1548-53 – reference: 17826100 - Bioorg Med Chem. 2007 Nov 15;15(22):6900-8 – reference: 9414270 - Blood. 1998 Jan 1;91(1):64-74 – reference: 19840779 - Brain Res. 2010 Jan 11;1307:22-7 – reference: 15910986 - J Neurosci Methods. 2005 Jun 15;144(2):257-63 – reference: 15086555 - J Invest Dermatol. 2004 Mar;122(3):691-8 – reference: 19422397 - Br J Pharmacol. 2009 Oct;158(4):972-81 – reference: 16923160 - J Neurochem. 2006 Sep;98(5):1474-86 – reference: 12432925 - Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:303-12 – reference: 20059330 - Annu Rev Med. 2010;61:17-33 – reference: 16834755 - CNS Drug Rev. 2006 Spring;12(1):9-20 – reference: 18384889 - Trends Pharmacol Sci. 2008 May;29(5):268-75 – reference: 15033436 - Brain Res. 2004 Apr 9;1004(1-2):198-202 – reference: 20157789 - Mol Neurobiol. 2010 Jun;41(2-3):172-9 – reference: 8683259 - J Neurosurg. 1996 Jul;85(1):112-6 – reference: 12194501 - Neuroscientist. 2002 Aug;8(4):323-34 – reference: 20801095 - Arch Biochem Biophys. 2010 Nov 15;503(2):161-74 – reference: 19542051 - Stroke. 2009 Sep;40(9):3121-6 – reference: 663662 - Science. 1978 Jul 28;201(4353):358-60 – reference: 21427623 - J Trauma. 2011 Nov;71(5):1211-8 – reference: 6309072 - Ann Neurol. 1983 Jun;13(6):625-32 – reference: 10657944 - Am J Respir Cell Mol Biol. 2000 Feb;22(2):226-34 – reference: 16500106 - Bioorg Med Chem. 2006 Jun 15;14(12):4295-301 – reference: 11740205 - J Cereb Blood Flow Metab. 2001 Dec;21(12):1436-41 – reference: 15637315 - Stroke. 2005 Feb;36(2):189-92 – reference: 18233953 - Annu Rev Pathol. 2008;3:279-312 – reference: 9403693 - Nature. 1997 Dec 11;390(6660):622-5 – reference: 22074807 - Neurobiol Aging. 2012 Mar;33(3):629.e1-3 – reference: 18202308 - Stroke. 2008 Feb;39(2):525 – reference: 15487674 - Sci Am. 2004 Oct;291(4):82-9 – reference: 2834836 - Stroke. 1988 Apr;19(4):480-5 – reference: 9292733 - Neuron. 1997 Aug;19(2):453-63 – reference: 15450084 - Eur J Neurosci. 2004 Oct;20(8):2049-58 – reference: 7903353 - J Neurochem. 1994 Jan;62(1):376-9 – reference: 10560610 - Prostaglandins Other Lipid Mediat. 1999 Oct;58(2-4):65-75 – reference: 14770184 - Nat Genet. 2004 Mar;36(3):233-9 – reference: 17053180 - Stroke. 2006 Dec;37(12):3014-8 – reference: 21838667 - Cardiovasc Hematol Agents Med Chem. 2011 Jul 1;9(3):154-64 – reference: 10432118 - Nature. 1999 Jul 22;400(6742):378-82 – reference: 9473716 - Brain Res Mol Brain Res. 1998 Jan;53(1-2):333-8 – reference: 21719775 - Stroke. 2011 Aug;42(8):2308-14 – reference: 23192915 - Ann Neurol. 2013 Jan;73(1):129-35 – reference: 12521597 - Free Radic Biol Med. 2003 Jan 15;34(2):145-69 – reference: 20640551 - Age (Dordr). 2010 Sep;32(3):271-82 – reference: 16453316 - Ann Neurol. 2006 Mar;59(3):467-77 – reference: 18323512 - Stroke. 2008 Apr;39(4):1109-14 – reference: 21423332 - Transl Stroke Res. 2011 Mar;2(1):33-41 – reference: 11158633 - Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1294-9 – reference: 12917400 - J Biol Chem. 2003 Oct 31;278(44):43508-15 – reference: 22155783 - Mol Pharmacol. 2012 Mar;81(3):420-30 – reference: 20229265 - Pflugers Arch. 2010 Jul;460(2):525-42 – reference: 18840431 - Exp Eye Res. 2009 Feb;88(2):133-9 – reference: 9445321 - Stroke. 1998 Jan;29(1):12-7 – reference: 12923200 - J Biol Chem. 2003 Oct 31;278(44):43807-17 – reference: 22700906 - Science. 2012 Jun 15;336(6087):1386-7 – reference: 17608719 - FEBS J. 2007 Jul;274(14):3503-12 – reference: 16480270 - J Med Chem. 2006 Feb 23;49(4):1356-63 – reference: 18202310 - Stroke. 2008 Feb;39(2):521-2 – reference: 17272759 - Stroke. 2007 Mar;38(3):1063-8 – reference: 17687131 - N Engl J Med. 2007 Aug 9;357(6):562-71 – reference: 21353711 - Trends Neurosci. 2011 Apr;34(4):198-209 – reference: 20368741 - Nat Rev Neurol. 2010 May;6(5):256-65 – reference: 18635843 - Stroke. 2008 Sep;39(9):2538-43 – reference: 12125346 - Methods Enzymol. 2002;352:183-90 – reference: 15637312 - Stroke. 2005 Feb;36(2):182-5 – reference: 18308347 - Neuropharmacology. 2008 Sep;55(3):363-89 – reference: 17960827 - J Neurosci Res. 2008 Mar;86(4):904-9 – reference: 11526430 - Cell Death Differ. 2001 Aug;8(8):776-84 – reference: 20068575 - J Cereb Blood Flow Metab. 2010 Jun;30(6):1157-67 – reference: 20357438 - Cerebrovasc Dis. 2010;29(6):528-37 – reference: 17622306 - Mol Med. 2007 Jul-Aug;13(7-8):350-5 – reference: 21356152 - Expert Rev Mol Med. 2011;13:e7 – reference: 18439837 - Pharmacol Res. 2008 Apr;57(4):266-73 – reference: 20673332 - J Neuroinflammation. 2010;7:42 – reference: 11231012 - FEBS Lett. 2001 Jan 26;489(1):51-4 – reference: 20670828 - Neuron. 2010 Jul 29;67(2):181-98 – reference: 18762024 - Cell Metab. 2008 Sep;8(3):237-48 – reference: 15853750 - Curr Drug Targets Cardiovasc Haematol Disord. 2005 Apr;5(2):177-84 – reference: 2180770 - FASEB J. 1990 Apr 1;4(6):1624-33 – reference: 21673716 - J Cereb Blood Flow Metab. 2011 Nov;31(11):2218-30 – reference: 17261713 - Stroke. 2007 Feb;38(2 Suppl):674-6 – reference: 20138164 - Brain Res. 2010 Apr 6;1323:174-83 – reference: 19091170 - Curr Cardiol Rep. 2009 Jan;11(1):12-20 – reference: 21620406 - Atherosclerosis. 2011 Sep;218(1):181-7 – reference: 20868723 - Biochimie. 2011 Jan;93(1):46-51 – reference: 15180492 - Curr Drug Metab. 2004 Jun;5(3):225-34 – reference: 17167069 - FASEB J. 2007 Mar;21(3):743-53 – reference: 11498518 - Br J Pharmacol. 2001 Aug;133(8):1323-9 – reference: 17942241 - Neuroscience. 2007 Dec 12;150(3):585-91 – reference: 15686484 - J Neurochem. 2005 Feb;92(4):824-30 – reference: 16166580 - Stroke. 2005 Oct;36(10):2258-64 – reference: 9854309 - Trends Cell Biol. 1998 Nov;8(11):436 – reference: 10446122 - J Biol Chem. 1999 Aug 20;274(34):23679-82 – reference: 20494126 - Biochem Biophys Res Commun. 2010 May 21;396(1):135-9 – reference: 19853588 - Brain Res. 2010 Jan 11;1307:149-57 – reference: 9160751 - Cell. 1997 May 16;89(4):597-606 – reference: 22542947 - Exp Neurol. 2012 Jul;236(1):122-30 – reference: 6719118 - Science. 1984 May 25;224(4651):886-9 – reference: 21835339 - Neuron. 2011 Aug 11;71(3):406-24 – reference: 16282974 - Nat Genet. 2006 Jan;38(1):68-74 – reference: 19808012 - Prostaglandins Other Lipid Mediat. 2010 Apr;91(3-4):104-12 – reference: 11207368 - Cell. 2001 Jan 26;104(2):281-90 – reference: 14698463 - Neurosci Lett. 2004 Jan 9;354(2):163-5 – reference: 22709986 - Neurobiol Dis. 2012 Oct;48(1):58-65 – reference: 12204769 - Life Sci. 2002 Sep 20;71(18):2105-17 – reference: 12909283 - Brain Res Bull. 2003 Aug 30;61(4):399-406 – reference: 21867913 - Chem Biol. 2011 Aug 26;18(8):976-87 – reference: 18545259 - J Cereb Blood Flow Metab. 2008 Oct;28(10):1686-96 – reference: 20689558 - Cell Death Differ. 2011 Feb;18(2):282-92 – reference: 16443152 - Free Radic Biol Med. 2006 Feb 1;40(3):376-87 – reference: 3087141 - Adv Enzymol Relat Areas Mol Biol. 1986;58:191-272 – reference: 18549870 - Am J Cardiol. 2008 Jun 16;101(12A):34F-40F – reference: 19737346 - J Neurochem. 2009 Nov;111(3):882-9 – reference: 18202309 - Stroke. 2008 Feb;39(2):523-4 – reference: 14672754 - Life Sci. 2004 Jan 9;74(8):969-85 – reference: 21957234 - J Neurosci. 2011 Sep 28;31(39):13710-21 – reference: 18309145 - Stroke. 2008 Apr;39(4):1389-91 – reference: 12395100 - Neuroreport. 2002 Oct 28;13(15):1963-6 – reference: 16005201 - Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct;73(3-4):141-62 – reference: 5473492 - Biochim Biophys Acta. 1970 Oct 6;218(1):1-10 |
| SSID | ssj0046317 |
| Score | 2.217289 |
| SecondaryResourceType | review_article |
| Snippet | Neuroprotection as approach to stroke therapy has recently seen a revival of sorts, fueled in part by the continuing necessity to improve acute stroke care,... |
| SourceID | pubmed |
| SourceType | Index Database |
| StartPage | 191 |
| SubjectTerms | Animals Arachidonic Acid - metabolism Enzyme Inhibitors - therapeutic use Humans Lipoxygenase - metabolism Models, Biological Stroke - drug therapy Stroke - enzymology Stroke - pathology |
| Title | Lipoxygenase: an emerging target for stroke therapy |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/23394536 |
| Volume | 12 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ1LS8QwEMeDj4sX8f2WHGQvbtc-0mzrTURZfOFhF7xJHlMQtbu4FVw_vZOkdbuLinoppSkh9NdMZkLmP4QcCCZ90AHzJIsTDFBi7QkBocd56EsWgGTKbOhf3_BOj13cxXfjwok2u6SQLfX-ZV7Jf6jiM-RqsmT_QPazU3yA98gXr0gYr79ifPUw6L-NsFm4FHOcqybf19Ydcke87SnCYfHSf4TDoiYgUGkT3Lgw3qpaVlZQl4Kcw0P98lp19Ol62zq_MHLW6vJJTG4cmCIO1cmpFjhjZw4g45wOJqxhWKMe1kxb4KpqTZtcE9KY6B8DL6PlFljJOFzifKcBXKMweLYYwihKWexUT35unRLCrppmySyGBKbGqdmYcYsu4-gHucxIM6Cjr4ZjdJ_LLqZiCOtLdJfIYhkE0BNHdJnMQL5CGrdORXzUpN1xUtywSRv0dqwvPlolUR37MRU5raBTx4oidOqg0xL6Gumdn3VPO15Z-8KT6GIXnvaDJNXofiqlNRORNEWSQESQ-FEbtJLohyqWKkAfLeNcgcwCriFRiRA6wpfXyVzez2GTUME4iHbaVhBmzNc6CbhkWaq4wAmpEr1FNtzHuB84gZP76jNtf9uyQxbGv9Qumc9wRsEeumeF3LdgPgC03DhT |
| linkProvider | National Library of Medicine |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Lipoxygenase%3A+an+emerging+target+for+stroke+therapy&rft.jtitle=CNS+%26+neurological+disorders+drug+targets&rft.au=van+Leyen%2C+Klaus&rft.date=2013-03-01&rft.eissn=1996-3181&rft.volume=12&rft.issue=2&rft.spage=191&rft_id=info:doi/10.2174%2F18715273112119990053&rft_id=info%3Apmid%2F23394536&rft_id=info%3Apmid%2F23394536&rft.externalDocID=23394536 |