The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases

• Published in: Current genomics Vol. 15; no. 1; pp. 38 - 51
• Main Authors: Saez, Isabel, Vilchez, David
• Format: Journal Article
• Language: English
• Published: Bentham Science Publishers Ltd 01.02.2014

Damaged and misfolded proteins accumulate during the aging process, impairing cell function and tissue homeostasis. These perturbations to protein homeostasis (proteostasis) are hallmarks of age-related neurodegenerative disorders such as Alzheimer's, Parkinson's or Huntington's disea...