Fibrosis, gene expression and orbital inflammatory disease

• Published in: British journal of ophthalmology Vol. 99; no. 10; pp. 1424 - 1429
• Main Authors: Rosenbaum, James T, Choi, Dongseok, Wilson, David J, Grossniklaus, Hans E, Harrington, Christina A, Dailey, Roger A, Ng, John D, Steele, Eric A, Czyz, Craig N, Foster, Jill A, Tse, David, Alabiad, Chris, Dubovy, Sander, Parekh, Prashant, Harris, Gerald J, Kazim, Michael, Patel, Payal, White, Valerie, Dolman, Peter, Edward, Deepak P, Alkatan, Hind, al Hussain, Hailah, Selva, Dinesh, Yeatts, Patrick, Korn, Bobby, Kikkawa, Don, Stauffer, Patrick, Planck, Stephen R
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.10.2015
• Subjects: Adipocytes; Adult; Age; Biopsy; Eye diseases; Female; Fibrosis - genetics; Fibrosis - pathology; Gene Expression; Gene Expression Profiling - methods; Humans; Inflammation; Inflammatory diseases; Lacrimal Apparatus - pathology; Male; Microarray Analysis - methods; Middle Aged; Orbit - pathology; Orbital Pseudotumor - diagnosis; Orbital Pseudotumor - genetics; Pathogenesis; Pathology; Pulmonary fibrosis; RNA - genetics; Sarcoidosis; Scleroderma; Thyroid gland; Orbit; Inflammation; Lacrimal gland

Background/aimsTo clarify the pathogenesis of fibrosis in inflammatory orbital diseases, we analysed the gene expression in orbital biopsies and compared our results with those reported for idiopathic pulmonary fibrosis.MethodsWe collected 140 biopsies from 138 patients (58 lacrimal glands; 82 orbit...