Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders

• Published in: Current medicinal chemistry Vol. 16; no. 2; p. 157
• Main Authors: Blaylock, R L, Strunecka, A
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 2009
• Subjects: Autistic Disorder - etiology; Autistic Disorder - immunology; Autistic Disorder - prevention & control; Brain - physiology; Brain - physiopathology; Child; Child, Preschool; Environmental Pollutants - toxicity; Glutamic Acid - metabolism; Humans; Immune System Diseases - genetics; Immune System Diseases - immunology; Microglia - immunology; Microglia - metabolism; Synaptic Transmission

Despite the great number of observations being made concerning cellular and the molecular dysfunctions associated with autism spectrum disorders (ASD), the basic central mechanism of these disorders has not been proposed in the major scientific literature. Our review brings evidence that most hetero...