Regulation and quantification of cellular mitochondrial morphology and content

• Published in: Current pharmaceutical design Vol. 20; no. 35; p. 5634
• Main Authors: Tronstad, Karl J, Nooteboom, Marco, Nilsson, Linn I H, Nikolaisen, Julie, Sokolewicz, Maciek, Grefte, Sander, Pettersen, Ina K N, Dyrstad, Sissel, Hoel, Fredrik, Willems, Peter H G M, Koopman, Werner J H
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2014
• Subjects: Animals; Cell Death - physiology; Cell Shape - physiology; Cell Survival - physiology; Energy Metabolism - physiology; Humans; Mitochondria - physiology; Mitochondria - ultrastructure

Mitochondria play a key role in signal transduction, redox homeostasis and cell survival, which extends far beyond their classical functioning in ATP production and energy metabolism. In living cells, mitochondrial content ("mitochondrial mass") depends on the cell-controlled balance betwe...