Microfibrillar-associated protein 4 modulates airway smooth muscle cell phenotype in experimental asthma

• Published in: Thorax Vol. 70; no. 9; pp. 862 - 872
• Main Authors: Pilecki, Bartosz, Schlosser, Anders, Wulf-Johansson, Helle, Trian, Thomas, Moeller, Jesper B, Marcussen, Niels, Aguilar-Pimentel, Juan A, de Angelis, Martin Hrabe, Vestbo, Jorgen, Berger, Patrick, Holmskov, Uffe, Sorensen, Grith L
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.09.2015
• Subjects: Animals; Antibodies; Asthma; Asthma - metabolism; Blotting, Western; Carrier Proteins - metabolism; Cell Adhesion; Cell adhesion & migration; Cell Culture Techniques; Cell Proliferation; Cytokines; Disease Models, Animal; Extracellular Matrix Proteins - metabolism; Female; Glycoproteins - metabolism; Humans; Kinases; Lung - metabolism; Mice; Myocytes, Smooth Muscle - metabolism; Penicillin; Phenotype; Proteins; Real-Time Polymerase Chain Reaction; Signal transduction; Smooth muscle; Asthma Mechanisms

BackgroundRecently, several proteins of the extracellular matrix have been characterised as active contributors to allergic airway disease. Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein abundant in the lung, whose biological functions remain poorly understood. In the...