Phenylephrine versus ephedrine on cerebral perfusion during carotid endarterectomy (PEPPER): study protocol for a randomized controlled trial - Pennekamp, Claire WA; Immink, Rogier V; Buhre, Wolfgang F; Moll, Frans L; de Borst, Gert Jan (Trials, 2013)
Keywords: Biomedicine; Carotid Artery Diseases - diagnosis; Carotid Artery Diseases - physiopathology; Carotid Artery Diseases - surgery; Cerebrovascular Circulation - drug effects; Clinical Protocols; Comparative analysis; Endarterectomy; Endarterectomy, Carotid - adverse effects; Ephedrine; Ephedrine - administration & dosage; Health Sciences; Hemodynamics - drug effects; Homeostasis; Humans; Hypotension - diagnosis; Hypotension - drug therapy; Hypotension - etiology; Hypotension - physiopathology; Laws, regulations and rules; Medicine; Medicine & Public Health; Middle Cerebral Artery - diagnostic imaging; Middle Cerebral Artery - drug effects; Middle Cerebral Artery - physiopathology; Monitoring, Intraoperative - methods; Netherlands; Phenylephrine; Phenylephrine - administration & dosage; Prospective Studies; Research Design; Spectroscopy, Near-Infrared; Statistics for Life Sciences; Study Protocol; Time Factors; Treatment Outcome; Ultrasonography, Doppler, Transcranial; Vasoconstrictor Agents - administration & dosage; Cerebral oxygenation; Carotid endarterectomy; Intraoperative hypotension; Phenylephrine; Ephedrine