Prevalence of interferon type I signature in CD14 monocytes of patients with Sjögren's syndrome and association with disease activity and BAFF gene expression

• Published in: Annals of the rheumatic diseases Vol. 72; no. 5; pp. 728 - 735
• Main Authors: Brkic, Zana, Maria, Naomi I, van Helden-Meeuwsen, Cornelia G, van de Merwe, Joop P, van Daele, Paul L, Dalm, Virgil A, Wildenberg, Manon E, Beumer, Wouter, Drexhage, Hemmo A, Versnel, Marjan A
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and European League Against Rheumatism 01.05.2013; Elsevier Limited; BMJ Group
• Series: Extended report
• Subjects: Adult; Aged; Autoimmune diseases; B-Cell Activating Factor - genetics; Biomarkers - metabolism; Clinical and Epidemiological Research; Dendritic cells; Disease; Female; Gene expression; Gene Expression - immunology; Hepatitis; Histopathology; Humans; Interferon Type I - metabolism; Lipopolysaccharide Receptors - metabolism; Male; Middle Aged; Monocytes - immunology; Monocytes - metabolism; Pathogenesis; Prevalence; Real-Time Polymerase Chain Reaction; RNA, Messenger - metabolism; Sjogren's Syndrome - epidemiology; Sjogren's Syndrome - immunology; Studies; Up-Regulation - immunology

Objective To determine the prevalence of upregulation of interferon (IFN) type I inducible genes, the so called ‘IFN type I signature’, in CD14 monocytes in 69 patients with primary Sjögren's syndrome (pSS) and 44 healthy controls (HC) and correlate it with disease manifestations and expression...