Long term treatment of myasthenia gravis with azathioprine

• Published in: Postgraduate medical journal Vol. 66; no. 772; pp. 102 - 105
• Main Authors: Fonseca, V., Havard, C. W.
• Format: Journal Article
• Language: English
• Published: England The Fellowship of Postgraduate Medicine 01.02.1990; Oxford University Press; BMJ Group
• Subjects: Adult; Azathioprine - adverse effects; Azathioprine - therapeutic use; Drug Therapy, Combination; Female; Humans; Hypertension, Portal - chemically induced; Jaundice - chemically induced; Long-Term Care; Male; Middle Aged; Myasthenia Gravis - drug therapy; Prednisolone - therapeutic use; Pyridostigmine Bromide - therapeutic use

Twenty-seven patients with myasthenia gravis have been treated with azathioprine in conjunction with pyridostigmine and prednisolone for a total of 138 patient years. Side effects necessitated discontinuation of treatment in only four patients. Treatment with azathioprine was associated with marked...