Pro-inflammatory gene expression and neurotoxic effects of activated microglia are attenuated by absence of CCAAT/enhancer binding protein β

• Published in: Journal of neuroinflammation Vol. 8; no. 1; p. 156
• Main Authors: Straccia, Marco, Gresa-Arribas, Núria, Dentesano, Guido, Ejarque-Ortiz, Aroa, Tusell, Josep M, Serratosa, Joan, Solà, Carme, Saura, Josep
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.11.2011; BioMed Central; BMC
• Subjects: Animals; Astrocytes - cytology; Astrocytes - drug effects; Astrocytes - physiology; CCAAT-Enhancer-Binding Protein-beta - genetics; CCAAT-Enhancer-Binding Protein-beta - metabolism; Cells, Cultured; Coculture Techniques; Cytokines - genetics; Cytokines - metabolism; Expressió gènica; Female; Gene Expression; Inflamació; Inflammation; Inflammation - genetics; Inflammation - metabolism; Interferon-gamma - pharmacology; Lipopolysaccharides - pharmacology; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia - cytology; Microglia - drug effects; Microglia - physiology; Neurons - cytology; Neurons - physiology; Neurotoxicologia; Neurotoxicology; Nitric Oxide - metabolism; Nitric Oxide Synthase Type II - genetics; Nitric Oxide Synthase Type II - metabolism; Pregnancy

Microglia and astrocytes respond to homeostatic disturbances with profound changes of gene expression. This response, known as glial activation or neuroinflammation, can be detrimental to the surrounding tissue. The transcription factor CCAAT/enhancer binding protein β (C/EBPβ) is an important regul...