Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA)

• Published in: Annals of the rheumatic diseases Vol. 72; no. 6; pp. 901 - 907
• Main Authors: Hughes-Austin, Jan M, Deane, Kevin D, Derber, Lezlie A, Kolfenbach, Jason R, Zerbe, Gary O, Sokolove, Jeremy, Lahey, Lauren J, Weisman, Michael H, Buckner, Jane H, Mikuls, Ted R, O'Dell, James R, Keating, Richard M, Gregersen, Peter K, Robinson, William H, Holers, V Michael, Norris, Jill M
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and European League Against Rheumatism 01.06.2013; BMJ Publishing Group LTD
• Subjects: Adult; Aged; Arthritis, Rheumatoid - genetics; Arthritis, Rheumatoid - immunology; Autoantibodies - immunology; Autoimmunity - genetics; Autoimmunity - immunology; Biomarkers; C-Reactive Protein - immunology; Chemokines; Chemokines - immunology; Cohort Studies; Cytokines; Cytokines - immunology; Female; Genetic Predisposition to Disease; Genotype & phenotype; Granulocyte-Macrophage Colony-Stimulating Factor - immunology; Health risk assessment; Humans; Inflammation; Inflammation - immunology; Interferon-gamma - immunology; Interleukin-2 - immunology; Interleukin-6 - immunology; Interleukin-9 - immunology; Logistic Models; Male; Middle Aged; Peptides, Cyclic - immunology; Phenotype; Population; Prospective Studies; Rheumatoid arthritis; Rheumatoid Factor - immunology; Rheumatology; Studies; Tumor necrosis factor-TNF

Objective We investigated whether rheumatoid arthritis (RA)-related autoantibodies were associated with systemic inflammation in a prospective cohort of first-degree relatives (FDRs) of RA probands, a population without RA but at increased risk for its future development. Methods We studied 44 autoa...