Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor-β phosphorylation, and microvessel density in gastric cancer

• Published in: BMC cancer Vol. 10; no. 1; p. 659
• Main Authors: Suzuki, Shioto, Dobashi, Yoh, Hatakeyama, Yayoi, Tajiri, Ryosuke, Fujimura, Takashi, Heldin, Carl H, Ooi, Akishi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.11.2010; BioMed Central; BMC
• Subjects: Adenocarcinoma - blood supply; Adenocarcinoma - chemistry; Adenocarcinoma - mortality; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Adult; Aged; Aged, 80 and over; Antigens, CD34 - analysis; Chi-Square Distribution; Female; Gastrectomy; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - analysis; Immunohistochemistry; Japan; Kaplan-Meier Estimate; Male; MEDICIN; MEDICINE; Microvessels - chemistry; Microvessels - pathology; Middle Aged; Neoplasm Invasiveness; Neovascularization, Pathologic - metabolism; Neovascularization, Pathologic - pathology; Pericytes - chemistry; Pericytes - pathology; Phosphorylation; Proto-Oncogene Proteins c-sis - analysis; Receptor, Platelet-Derived Growth Factor beta - analysis; Stomach Neoplasms - blood supply; Stomach Neoplasms - chemistry; Stomach Neoplasms - mortality; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Treatment Outcome; Vascular Endothelial Growth Factor A - analysis; Japan

Angiogenesis is important in the growth and metastasis of various kinds of solid tumors, including gastric cancers. The angiogenic process is triggered by several key growth factors, including vascular endothelial growth factor (VEGF)-A and platelet-derived growth factor (PDGF)-B, that are secreted...