Heritability of Brachydactyly Type A3 in Children, Adolescents, and Young Adults from an Endogamous Population in Eastern Nepal

• Published in: Human biology Vol. 79; no. 6; pp. 609 - 622
• Main Authors: Williams, Kimberly D., Blangero, John, Cottom, Carol R., Lawrence, Sharon, Choh, Audrey C., Czerwinski, Stefan A., Lee, Miryoung, Duren, Dana L., Sherwood, Richard J., Dyer, Thomas D., Jha, Bharat, Subedi, Janardan, Williams-Blangero, Sarah, Towne, Bradford
• Format: Journal Article
• Language: English
• Published: United States Wayne State University Press 01.12.2007
• Subjects: Abnormalities; Adolescent; Adult; Bones; BRACHYDACTYLY; BRACHYDACTYLY TYPE A3 (BDA3); Child; Child growth; Child, Preschool; Children; Evaluation; Female; Finger Phalanges - abnormalities; Finger Phalanges - diagnostic imaging; Genetic aspects; Genetics; Genetics, Population - methods; Hand Deformities, Congenital - diagnostic imaging; Hand Deformities, Congenital - epidemiology; Hand Deformities, Congenital - genetics; Heredity; Heritability; Human biology; Human genetics; Human subjects; Humans; JIRELS; Male; Males; Medical genetics; Medical research; Minority & ethnic groups; Musculoskeletal abnormalities; NEPAL; Nepal - epidemiology; PHALANGES; Phalanges (Bones); Phenotype; Phenotypic traits; Population genetics; Prevalence; Quantitative genetics; Radiography; s; SKELETAL ANOMALIES OF THE HAND; Studies; Nepal

Brachymesophalangia-V (BMP-V), a short and broad middle phalanx of the fifth digit, is the most common of all skeletal anomalies of the hand. When this feature appears alone, it is clinically known as brachydactyly type A3 (BDA3). A high prevalence of BDA3 has been observed among the children of the...