Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress

• Published in: Gut Vol. 53; no. 8; pp. 1102 - 1108
• Main Authors: Posserud, I, Agerforz, P, Ekman, R, Björnsson, E S, Abrahamsson, H, Simrén, M
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.08.2004; BMJ; BMJ Publishing Group LTD; Copyright 2004 by Gut
• Subjects: ACTH; Adrenocorticotropic Hormone; Adrenocorticotropic Hormone - blood; Adult; Aged; alternating type IBS; Anxiety; Anxiety - physiopathology; Arousal; Arousal - physiology; Biological and medical sciences; blood; constipation predominant irritable bowel syndrome; corticotropin releasing factor; Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone - blood; CRF; Defecation; diarrhoea predominant irritable bowel syndrome; Epinephrine; Epinephrine - blood; Female; Gastroenterologi och hepatologi; Gastroenterology and Hepatology; Gastroenterology. Liver. Pancreas. Abdomen; HAD scale; Heart Rate; Heart Rate - physiology; Hormones; hospital anxiety and depression scale; Humans; Hydrocortisone; Hydrocortisone - blood; IBS; IBS-A; IBS-C; IBS-D; interquartile range; IQR; Irritable Bowel Syndrome; Irritable Bowel Syndrome - physiopathology; Irritable Bowel Syndrome - psychology; Male; Medical sciences; Middle Aged; Nervous system; neuroendocrine response; Norepinephrine; Norepinephrine - blood; Other diseases. Semiology; Pain; Pain - physiopathology; Pathophysiology; physiology; physiopathology; Psychological; psychology; rectal sensitivity; Rectum; Rectum - physiopathology; Sensory Thresholds; Sensory Thresholds - physiology; Spielberger state trait anxiety inventory; STAI; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Stress; Stress response; Stress, Psychological - physiopathology; VAS; visual analogue scale; Human; Response; Irritable bowel syndrome; Gastroenterology; Digestive diseases; Intestinal disease; Stress

Background and aims: Stress often worsens the symptoms of irritable bowel syndrome (IBS). We hypothesised that this might be explained by altered neuroendocrine and visceral sensory responses to stress in IBS patients. Subjects and methods: Eighteen IBS patients and 22 control subjects were assessed...