Traumatic brain injury and grey matter concentration: a preliminary voxel based morphometry study

• Published in: Journal of neurology, neurosurgery and psychiatry Vol. 76; no. 7; pp. 984 - 988
• Main Authors: Gale, S D, Baxter, L, Roundy, N, Johnson, S C
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.07.2005; BMJ; BMJ Publishing Group LTD; BMJ Group
• Subjects: Adult; Attention Deficit Disorder with Hyperactivity - diagnosis; Attention Deficit Disorder with Hyperactivity - etiology; Biological and medical sciences; Brain Concussion - diagnosis; Brain Concussion - pathology; Cephalometry - statistics & numerical data; Cerebellum - injuries; Cerebellum - pathology; Cerebral Cortex - injuries; Cerebral Cortex - pathology; Cognition Disorders - diagnosis; Cognition Disorders - pathology; Coma; Conners continuous performance test; CPT-II; Demographics; Dominance, Cerebral - physiology; Family medical history; Female; Follow-Up Studies; GCS; Glasgow coma scale; Head Injuries, Closed - diagnosis; Head Injuries, Closed - pathology; Humans; Image Processing, Computer-Assisted - methods; Imaging, Three-Dimensional - methods; Injuries of the nervous system and the skull. Diseases due to physical agents; Magnetic Resonance Imaging - methods; Male; Mathematical Computing; Medical imaging; Medical sciences; MNI; Montreal Neurological Institute; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; neuroimaging; Neurology; Neuropsychological Tests; NMR; Nuclear magnetic resonance; region of interest; ROI; Schizophrenia; second edition; SPGR; SPM; spoiled gradient echo; Statistical analysis; statistical parametric mapping; Studies; Tomography; Traumas. Diseases due to physical agents; Traumatic brain injury; VBM; voxel based morphometry; Nervous system diseases; Head trauma; Morphometry; Grey matter; Voxel

Background: Magnetic resonance imaging (MRI) studies have shown diffuse cerebral atrophy following traumatic brain injury. In the past, quantitative volumetric analysis of these changes was carried out by manually tracing specific regions of interest. In contrast, voxel based morphometry (VBM) is a...