Acute nasal pro-inflammatory response to air pollution depends on characteristics other than particle mass concentration or oxidative potential: the RAPTES project

• Published in: Occupational and environmental medicine (London, England) Vol. 70; no. 5; pp. 341 - 348
• Main Authors: Steenhof, Maaike, Mudway, Ian S, Gosens, Ilse, Hoek, Gerard, Godri, Krystal J, Kelly, Frank J, Harrison, Roy M, Pieters, Raymond H H, Cassee, Flemming R, Lebret, Erik, Brunekreef, Bert A, Strak, Maciej, Janssen, Nicole A H
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.05.2013; BMJ Publishing Group; BMJ Publishing Group LTD
• Subjects: Adult; Air; Air pollutants; Air Pollutants - adverse effects; Air Pollutants - analysis; Air pollution; Air Pollution - adverse effects; Air Pollution - analysis; Air pollution measurements; Air. Soil. Water. Waste. Feeding; Biological and medical sciences; Biological markers; Biomarkers; Biomarkers - blood; Blood; Carbon; Carbon - adverse effects; Carbon - analysis; Chemical composition; Cytokines; Datasets; Endotoxins; Endotoxins - adverse effects; Endotoxins - analysis; Environment; Environment. Living conditions; Environmental pollutants toxicology; Exercise; Female; Humans; Inflammation; Inflammation - blood; Inflammation - chemically induced; Inflammation Mediators - blood; Inhalation Exposure - adverse effects; Interleukins - blood; Lactoferrin - adverse effects; Lactoferrin - analysis; Male; Medical sciences; Metals; Nasal; Netherlands; Nitrates; Nitric Oxide - adverse effects; Nitric Oxide - analysis; Nitrogen dioxide; Organic carbon; Outdoor air quality; Oxidation-Reduction; Oxidative Potential; Oxidative Stress; Particulate Matter; Particulate Matter - adverse effects; Particulate Matter - analysis; Permeability; Pollutants; Proteins; Proteins - adverse effects; Proteins - analysis; Public health. Hygiene; Public health. Hygiene-occupational medicine; Rhinitis - blood; Rhinitis - chemically induced; Therapeutic irrigation; Toxicology; Urban agriculture; Young Adult; Netherlands; Europe; Human; Particle; Health and environment; Respiratory disease; Acute; Nose; Air pollution; Inflammation; Public health

Objectives To investigate which air pollution characteristics are associated with biomarkers for acute nasal airway inflammation in healthy subjects. We hypothesised that associations would be strongest for oxidative potential (OP) of particles. Methods 31 volunteers were exposed to ambient air poll...