Hsp90 Affecting Chromatin Remodeling Might Explain Transgenerational Epigenetic Inheritance in Drosophila
Transgenerational epigenetic inheritance, while poorly understood, is of great interest because it might help explain the increase in the incidence of diseases with an environmental contribution in humans, such as cancer, diabetes, and heart disease. Here, we review five Drosophila examples of trans...
Saved in:
| Published in | Current genomics Vol. 9; no. 7; pp. 500 - 508 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United Arab Emirates
Bentham Science Publishers Ltd
01.11.2008
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Transgenerational epigenetic inheritance, while poorly understood, is of great interest because it might help explain the increase in the incidence of diseases with an environmental contribution in humans, such as cancer, diabetes, and heart disease. Here, we review five Drosophila examples of transgenerational epigenetic inheritance and propose a unified mechanism that involves Polycomb Response Element/Trithorax Response Element (PRE/TRE) occupancy by either Polycomb Group (PcG) protein complexes or Trithorax group (TrxG) complexes. Among their other activities, PcG complexes cause histone 3 lysine 27 tri-methylation associated with repressed chromatin, whereas Trithorax group (TrxG) complexes induce histone 3 lysine 4 tri-methylation associated with actively transcribed chromatin. In this model, Hsp90 is an environmentally sensitive chromatin remodeling regulator that causes a switch in the chromatin from a permissive state to a non-permissive state for transcription. Consistent with this model, Hsp90 has recently been shown to be a chaperone for Tah1p (TPR-containing protein associated with Hsp90) and Pih1p (protein interacting with Hsp90), which connect to the chromatin remodelling factor Rvb1p (RuvB-like protein 1)/Rvb2p in yeast [1]. Also, Hsp90 is required for optimal activity of the histone H3 lysine-4 methyltransferase SMYD3 in mammals [2, 3]. Since PcG and TrxG complexes are involved in the post-translational modifications of histones, and since such modifications have been shown to be required to maintain imprinted marks, this unified mechanism might also help to explain transgenerational epigenetic inheritance in humans. |
|---|---|
| AbstractList | Transgenerational epigenetic inheritance, while poorly understood, is of great interest because it might help explain the increase in the incidence of diseases with an environmental contribution in humans, such as cancer, diabetes, and heart disease. Here, we review five Drosophila examples of transgenerational epigenetic inheritance and propose a unified mechanism that involves Polycomb Response Element/Trithorax Response Element (PRE/TRE) occupancy by either Polycomb Group (PcG) protein complexes or Trithorax group (TrxG) complexes. Among their other activities, PcG complexes cause histone 3 lysine 27 tri-methylation associated with repressed chromatin, whereas Trithorax group (TrxG) complexes induce histone 3 lysine 4 tri-methylation associated with actively transcribed chromatin. In this model, Hsp90 is an environmentally sensitive chromatin remodeling regulator that causes a switch in the chromatin from a permissive state to a non-permissive state for transcription. Consistent with this model, Hsp90 has recently been shown to be a chaperone for Tah1p (TPR-containing protein associated with Hsp90) and Pih1p (protein interacting with Hsp90), which connect to the chromatin remodelling factor Rvb1p (RuvB-like protein 1)/Rvb2p in yeast [1]. Also, Hsp90 is required for optimal activity of the histone H3 lysine-4 methyltransferase SMYD3 in mammals [2, 3]. Since PcG and TrxG complexes are involved in the post-translational modifications of histones, and since such modifications have been shown to be required to maintain imprinted marks, this unified mechanism might also help to explain transgenerational epigenetic inheritance in humans. Transgenerational epigenetic inheritance, while poorly understood, is of great interest because it might help explain the increase in the incidence of diseases with an environmental contribution in humans, such as cancer, diabetes, and heart disease. Here, we review five Drosophila examples of transgenerational epigenetic inheritance and propose a unified mechanism that involves Polycomb Response Element/Trithorax Response Element (PRE/TRE) occupancy by either Polycomb Group (PcG) protein complexes or Trithorax group (TrxG) complexes. Among their other activities, PcG complexes cause histone 3 lysine 27 tri-methylation associated with repressed chromatin, whereas Trithorax group (TrxG) complexes induce histone 3 lysine 4 tri-methylation associated with actively transcribed chromatin. In this model, Hsp90 is an environmentally sensitive chromatin remodeling regulator that causes a switch in the chromatin from a permissive state to a non-permissive state for transcription. Consistent with this model, Hsp90 has recently been shown to be a chaperone for Tah1p (TPR-containing protein associated with Hsp90) and Pih1p (protein interacting with Hsp90), which connect to the chromatin remodelling factor Rvb1p (RuvB-like protein 1)/Rvb2p in yeast [ 1 ]. Also, Hsp90 is required for optimal activity of the histone H3 lysine-4 methyltransferase SMYD3 in mammals [ 2 , 3 ]. Since PcG and TrxG complexes are involved in the post-translational modifications of histones, and since such modifications have been shown to be required to maintain imprinted marks, this unified mechanism might also help to explain transgenerational epigenetic inheritance in humans. |
| Author | Xiangyi Lu Douglas Ruden |
| AuthorAffiliation | Wayne State University, Institute for Environmental Health Sciences, 2727 2 nd Ave, Room 4000, Detroit, MI 48201, USA |
| AuthorAffiliation_xml | – name: Wayne State University, Institute for Environmental Health Sciences, 2727 2 nd Ave, Room 4000, Detroit, MI 48201, USA |
| Author_xml | – sequence: 1 givenname: Douglas M surname: Ruden fullname: Ruden, Douglas M organization: Wayne State University, Institute for Environmental Health Sciences, 2727 2 Ave, Room 4000, Detroit, MI 48201, USA – sequence: 2 givenname: Xiangyi surname: Lu fullname: Lu, Xiangyi |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19506739$$D View this record in MEDLINE/PubMed |
| BookMark | eNplkU1v1DAQhiNURD_gD3BAOXEL2E4cxxekarvQSkVIqJxHjjO7MTi2sZMuXPnleNmlgDh5PPPM6_G858WJ8w6L4jklrxgVzWtad5IRRjrRtayhjIhHxRntBK9403UnOc5AlQl5Wpyn9Jn8YsmT4pRKTlpRy7PCXKcgSXm52aCejduWqzH6SeWw_IiTH9Duk-_NdpzL9bdgVS7cReXSFh3GzHmnbLkOZn-fjS5v3IjRzMppLDN7FX3yYTRWPS0eb5RN-Ox4XhSf3q7vVtfV7Yd3N6vL26rnnM8VFURIrVQ9EEY172pChr7TUumBNGJAolnTE85FzwmqrpWDxppQ1Yu6HkSD9UXx5qAbln7CXHVzVBZCNJOK38ErA_9WnBlh6--BtZK2os0CL48C0X9dMM0wmaTRWuXQLwnyQjmTjGaQHUCdP5kibh4eoQT2DsH_DuWmF3-P96flaEkGfhyAPs83qilpg3mZD-A4zwF2ux3gEvGLSmizc6D9BD6gW6LNsZtzL4QxQLYlIqiYrbEIJiX3eygJ994uE4LcpxcEASmoLQInpP4Jed7CbQ |
| CitedBy_id | crossref_primary_10_1016_j_mce_2014_08_011 crossref_primary_10_1016_j_taap_2015_09_024 crossref_primary_10_1371_journal_pone_0059922 crossref_primary_10_1007_s00335_017_9729_0 crossref_primary_10_1371_journal_pbio_3002629 crossref_primary_10_1017_S0031182014000304 crossref_primary_10_1002_em_21701 crossref_primary_10_1016_j_reprotox_2012_08_010 crossref_primary_10_1371_journal_pone_0116360 crossref_primary_10_1038_s41598_017_00143_6 crossref_primary_10_3390_cells8060532 crossref_primary_10_6061_clinics_2013_Sup01_02 crossref_primary_10_1186_s13072_018_0178_0 crossref_primary_10_1002_ps_5396 crossref_primary_10_1371_journal_pone_0102091 crossref_primary_10_1016_j_sjbs_2020_11_003 crossref_primary_10_3109_1040841X_2014_962478 crossref_primary_10_1016_j_cbpc_2020_108918 crossref_primary_10_1007_s12038_019_9852_z crossref_primary_10_1038_s41419_022_05004_3 crossref_primary_10_1016_j_mce_2014_09_008 crossref_primary_10_1016_j_bbamcr_2011_09_003 crossref_primary_10_1038_mi_2015_4 crossref_primary_10_1093_eep_dvv010 crossref_primary_10_1371_journal_pone_0202662 crossref_primary_10_1073_pnas_1415195112 crossref_primary_10_1186_1741_7015_11_228 crossref_primary_10_1016_j_neulet_2015_10_060 crossref_primary_10_1016_j_reprotox_2012_11_011 crossref_primary_10_1093_eep_dvy010 crossref_primary_10_3389_fgene_2015_00060 crossref_primary_10_1007_s10265_012_0485_7 crossref_primary_10_1016_j_reprotox_2012_09_005 crossref_primary_10_1038_srep09303 crossref_primary_10_1093_eep_dvy016 crossref_primary_10_1093_gbe_evae022 crossref_primary_10_1098_rspb_2011_2646 crossref_primary_10_1111_mec_13072 crossref_primary_10_1186_1476_069X_13_62 crossref_primary_10_1016_j_gde_2014_06_005 crossref_primary_10_1002_bdra_20685 crossref_primary_10_1016_j_envpol_2010_07_023 crossref_primary_10_1371_journal_pone_0021640 crossref_primary_10_7717_peerj_12175 crossref_primary_10_1016_j_ceb_2014_12_005 crossref_primary_10_1074_jbc_C113_462770 crossref_primary_10_3390_cells8091108 crossref_primary_10_1242_jeb_153163 crossref_primary_10_1007_s00018_011_0808_1 crossref_primary_10_1093_eep_dvx016 crossref_primary_10_1093_g3journal_jkad287 crossref_primary_10_1371_journal_pone_0055387 |
| ContentType | Journal Article |
| Copyright | 2008 Bentham Science Publishers Ltd. 2008 |
| Copyright_xml | – notice: 2008 Bentham Science Publishers Ltd. 2008 |
| DBID | NPM AAYXX CITATION 7QO 7SS 7TM 8FD FR3 P64 RC3 5PM |
| DOI | 10.2174/138920208786241207 |
| DatabaseName | PubMed CrossRef Biotechnology Research Abstracts Entomology Abstracts (Full archive) Nucleic Acids Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts Genetics Abstracts PubMed Central (Full Participant titles) |
| DatabaseTitle | PubMed CrossRef Entomology Abstracts Genetics Abstracts Biotechnology Research Abstracts Technology Research Database Nucleic Acids Abstracts Engineering Research Database Biotechnology and BioEngineering Abstracts |
| DatabaseTitleList | Entomology Abstracts PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1875-5488 |
| EndPage | 508 |
| ExternalDocumentID | 10_2174_138920208786241207 19506739 http_www_eurekaselect_com_openurl_content_php_genre_article_issn_13892029_volume_9_issue_7_spage_500 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: NIEHS NIH HHS grantid: P30 ES006639 – fundername: NIDDK NIH HHS grantid: R01 DK071073 – fundername: NIEHS NIH HHS grantid: R01 ES012933 – fundername: NCI NIH HHS grantid: R01 CA105349 |
| GroupedDBID | --- .5. 0R~ 29F 2WC 4.4 53G 5GY AAEGP ABEEF ABJNI ACGFS ACIWK ACPRK ADBBV AENEX AFRAH AFUQM AGJNZ ALMA_UNASSIGNED_HOLDINGS ANTIV AOIJS BAWUL C1A CS3 DIK DU5 E3Z EBS EJD F5P GH2 GX1 HYE HZ~ IPNFZ KCGFV O9- OK1 P2P RIG RPM TR2 NPM AAYXX CITATION 7QO 7SS 7TM 8FD FR3 P64 RC3 5PM |
| ID | FETCH-LOGICAL-b555t-17079caa3d021c58300db8c9acd047de0c24b0557b50ea869dce301ab733d74e3 |
| IEDL.DBID | RPM |
| ISSN | 1389-2029 |
| IngestDate | Tue Apr 09 21:45:21 EDT 2024 Tue Aug 27 04:25:44 EDT 2024 Fri Aug 23 00:36:50 EDT 2024 Sat Sep 28 08:49:14 EDT 2024 Tue Aug 27 15:42:02 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Language | English |
| License | This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/) which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-b555t-17079caa3d021c58300db8c9acd047de0c24b0557b50ea869dce301ab733d74e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691676/ |
| PMID | 19506739 |
| PQID | 20252921 |
| PQPubID | 23462 |
| PageCount | 9 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2691676 proquest_miscellaneous_20252921 crossref_primary_10_2174_138920208786241207 pubmed_primary_19506739 benthamscience_primary_http_www_eurekaselect_com_openurl_content_php_genre_article_issn_13892029_volume_9_issue_7_spage_500 |
| PublicationCentury | 2000 |
| PublicationDate | 2008-11-01 |
| PublicationDateYYYYMMDD | 2008-11-01 |
| PublicationDate_xml | – month: 11 year: 2008 text: 2008-11-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | United Arab Emirates |
| PublicationPlace_xml | – name: United Arab Emirates |
| PublicationTitle | Current genomics |
| PublicationTitleAlternate | CG |
| PublicationYear | 2008 |
| Publisher | Bentham Science Publishers Ltd |
| Publisher_xml | – name: Bentham Science Publishers Ltd |
| References | 17460682 - Nat Genet. 2007 May;39(5):574-5; author reply 575-6 17583784 - Theriogenology. 2007 Sep 1;68 Suppl 1:S147-55 16424344 - Science. 2006 Jan 20;311(5759):395-8 15196466 - Curr Opin Genet Dev. 2004 Apr;14(2):188-95 15235609 - Nat Cell Biol. 2004 Aug;6(8):731-40 17660548 - Genetics. 2007 Sep;177(1):255-65 15031712 - EMBO Rep. 2004 Apr;5(4):373-7 7561850 - J Neurochem. 1995 Oct;65(4):1562-8 15303093 - Nat Cell Biol. 2004 Aug;6(8):685-7 18258182 - Biochem Biophys Res Commun. 2008 Apr 11;368(3):748-54 16615080 - Bioessays. 2006 May;28(5):453-9 16951683 - Nat Genet. 2006 Oct;38(10):1178-83 12483213 - Nat Genet. 2003 Jan;33(1):70-4 15064764 - Nat Genet. 2004 May;36(5):497-501 17339329 - Mol Cell Biol. 2007 May;27(10):3769-79 16847345 - Genes Dev. 2006 Jul 15;20(14):1848-67 9604927 - Cell. 1998 May 15;93(4):505-18 17246163 - Genetics. 1983 Oct;105(2):327-44 10440232 - Gene Expr. 1999;7(4-6):311-9 16630818 - Cell. 2006 Apr 21;125(2):301-13 16570078 - Nat Cell Biol. 2006 May;8(5):532-8 15520283 - Genes Dev. 2004 Nov 1;18(21):2639-51 11278922 - J Biol Chem. 2001 May 11;276(19):16279-88 12576485 - J Biol Chem. 2003 Apr 25;278(17):14647-56 14986860 - Semin Cell Dev Biol. 2003 Oct;14(5):301-10 9880553 - J Biol Chem. 1999 Jan 15;274(3):1723-8 15860605 - Science. 2005 Apr 29;308(5722):624-6 17344414 - Genes Dev. 2007 Mar 1;21(5):525-30 17173055 - Nat Rev Genet. 2007 Jan;8(1):9-22 12454070 - Genetics. 2002 Nov;162(3):1245-58 9722603 - J Cell Biol. 1998 Aug 24;142(4):887-98 9724781 - Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10779-84 15525518 - Mol Cell. 2004 Nov 5;16(3):465-77 11275305 - Trends Genet. 2001 Apr;17(4):169-72 17845077 - PLoS Genet. 2007 Sep;3(9):1598-606 9461509 - Biochem J. 1998 Feb 15;330 ( Pt 1):189-95 16724059 - Nature. 2006 May 25;441(7092):469-74 11226610 - Trends Genet. 2001 Mar;17(3):153-7 16625203 - Nature. 2006 May 18;441(7091):349-53 12695684 - Cell Cycle. 2003 Jan-Feb;2(1):34-5 3917552 - Nature. 1985 Jan 3-9;313(5997):27-32 15766533 - Cell. 2005 Mar 11;120(5):715-27 18035408 - Cell. 2007 Nov 30;131(5):861-72 17464249 - Cancer J. 2007 Jan-Feb;13(1):70-4 8825476 - Annu Rev Genet. 1995;29:289-303 16437107 - Nature. 2006 Jan 26;439(7075):430-6 12723694 - Genetica. 2003 Mar;117(2-3):149-58 12408864 - Cell. 2002 Oct 18;111(2):197-208 12127774 - Trends Genet. 2002 Jul;18(7):348-51 16531545 - Gut. 2006 Apr;55(4):586-7 16892059 - Nat Genet. 2006 Sep;38(9):1071-6 16157682 - Genetics. 2005 Dec;171(4):1583-95 10906465 - Mech Dev. 2000 Jul;95(1-2):215-7 6795427 - Mol Gen Genet. 1981;182(3):516-9 8248257 - Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11376-80 9845070 - Nature. 1998 Nov 26;396(6709):336-42 17255950 - EMBO J. 2007 Feb 7;26(3):720-9 18295320 - Front Neuroendocrinol. 2008 Jun;29(3):428-44 16868943 - Genesis. 2006 Sep;44(9):401-6 16604157 - PLoS Genet. 2006 Apr;2(4):e49 12533790 - Genesis. 2003 Feb;35(2):88-93 103000 - Nature. 1978 Dec 7;276(5688):565-70 16914306 - Curr Opin Genet Dev. 2006 Oct;16(5):476-84 9755190 - Genetics. 1998 Oct;150(2):563-76 15325253 - Biochem Biophys Res Commun. 2004 Sep 17;322(2):465-9 10542150 - Science. 1999 Oct 29;286(5441):955-8 16575167 - Cytogenet Genome Res. 2006;113(1-4):90-8 16987876 - Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R131-7 17467256 - Curr Opin Cell Biol. 2007 Jun;19(3):257-65 16630819 - Cell. 2006 Apr 21;125(2):315-26 11117732 - Nature. 2000 Nov 30;408(6812):538-40 11973279 - Development. 2002 May;129(10):2483-93 12408863 - Cell. 2002 Oct 18;111(2):185-96 9590165 - Cell. 1998 May 1;93(3):321-4 10545949 - Nat Genet. 1999 Nov;23(3):314-8 14522946 - Genes Dev. 2003 Oct 1;17(19):2406-20 12050657 - Nature. 2002 Jun 6;417(6889):618-24 18316406 - Mol Cell Biol. 2008 May;28(9):2884-95 15818385 - Nat Rev Genet. 2005 May;6(5):403-10 |
| References_xml | |
| SSID | ssj0020870 |
| Score | 2.1267052 |
| Snippet | Transgenerational epigenetic inheritance, while poorly understood, is of great interest because it might help explain the increase in the incidence of diseases... |
| SourceID | pubmedcentral proquest crossref pubmed benthamscience |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 500 |
| SubjectTerms | Drosophila |
| Title | Hsp90 Affecting Chromatin Remodeling Might Explain Transgenerational Epigenetic Inheritance in Drosophila |
| URI | http://www.eurekaselect.com/openurl/content.php?genre=article&issn=13892029&volume=9&issue=7&spage=500 https://www.ncbi.nlm.nih.gov/pubmed/19506739 https://search.proquest.com/docview/20252921 https://pubmed.ncbi.nlm.nih.gov/PMC2691676 |
| Volume | 9 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB51KyFxAPEmPEoO3FC6jhPH8bEqLQvSIoSotDfLdrzsim4a7eNQ9c8z4ziFpTeuifOczzOfk29mAN4b3rjKlTwzLlcZgSRDlmEz6fjcVb6RlaV85-nXanJRfpmJ2QGIIRcmiPadXR63l6vjdrkI2spu5caDTmz8bXrKKyQ1shqPYIThd1iix1UWq2WfGkzyHcZVnylDzHtM23gYQWkROWehBZ8S1KwFKeYDi35-YVYx9uxHqjv0818V5V9h6fwRPIx8Mj3p7_sxHPj2CdzrO0xeP4XlZNMplp4E1QZGqZSK4RJJbdPvPnTBoY1TWqGnJMczuCOEr5-hHHX_oTA966hmJ6U7pp9bShjcElZSHPtxHfogLC_NM7g4P_txOslid4XMCiG2WU618ZwxRYNh3om6YKyxtVPGNayUjWeOl5YqdFnBvKkrhQ-K3sBYWRSNLH3xHA7bq9a_hFTUbi4Fl1KJAgmZMhJ5TWXmyhiJpzMJ3Oy_Wt31pTRCUpFGm2u_W_tfZhN6_2icazo2D9Ok2Kd-w92i02FK6YgETU5SR5Mq3TtzrXTAq5Y6OGQtGEvgw2DH2-vi0ocQoe8iIoF3g6k1zjT6fWJaf7XbaBwnuOJ5Ai96w_85W4RQAnIPErcDqIb3_h6EdqjlHaH86r-PfA33g4QlpEe-gcPteuffIk_a2iMYfZrlR2F2_AbIthml |
| link.rule.ids | 230,314,727,780,784,885,27924,27925,53791,53793 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKEYIDiDfh1Ry4oXQdJ47jY1VabaFbIdRKvY1sx8uu6KbRPg6IP8-M4xSW3rgmznM-z3xOvplh7IMRjatcKTLjcp0RSDJkGTZTTkxd5RtVWcp3npxV44vy86W83GFyyIUJon1n5_vt1WK_nc-CtrJbuNGgExt9nRyKCkmNqkZ32F1ZKJ0Pi_S4zuK16pODScDDhe5zZYh7j2ibCCMoMSIXPDTh05LatSDJfGjR08_MIkaf7Vh1i4D-q6P8KzAdP2aPIqNMD_o7f8J2fPuU3et7TP58xubjVad5ehB0GxinUiqHSzS1Tb_50AeHNk5ojZ6SIM_gjhDAvoeC1P2nwvSoo6qdlPCYnrSUMrgmtKQ49tMydEKYX5nn7OL46PxwnMX-CpmVUq6znKrjOWOKBgO9k3XBeWNrp41reKkaz50oLdXospJ7U1caHxT9gbGqKBpV-uIF222vW_-KpbJ2UyWFUloWSMm0UchsKjPVxig8nUnYr-1XC11fTCOkFQFaHfxm6X-YVej-AzjbILYPA9LsU8fhbtZBmFQQsQDkJiGaVEPvzkFDQCwoCC4ZJOcJ-zjY8ea6uPghRMBtRCRsbzA14FyjHyim9debFeA4KbTIE_ayN_yfs0UIJUxtQeJmAFXx3t6D4A7VvCOYX__3kXvs_vh8cgqnJ2df3rAHQdASkiXfst31cuPfIWta2_dhjvwGDgYcCQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagCNQDiHfDqzlwQ2m8ThzHx6rtagtsVSEq9TayHS-7optG-zgg_jwzjrd06Y1r4jzn88znZGY-xj4a0bjKlSIzbqAzAkmGLMNmyomJq3yjKkv1zuOzanRRfr6Ul7ekvkLSvrOzg_ZqftDOpiG3spu7fJMnlp-Pj0SFpEZVeddM8vvsgSwQZJuFelxr8Vr1BcKUxMOF7utliH_ntE2EEVQcMRA8CPFpSZItSDQfW_T2UzOPEWg7Xt0hof_mUt4KTsOn7Elklelhf_fP2D3fPmcPe53JXy_YbLTsNE8PQ-4GxqqUWuISVW3Tbz5o4dDGMa3TU0rKM7gjBLEfoSl1_7kwPemocycVPaanLZUNrggxKY49XgQ1hNmVeckuhiffj0ZZ1FjIrJRylQ2oQ54zpmgw2DtZF5w3tnbauIaXqvHcidJSny4ruTd1pfFB0ScYq4qiUaUvXrGd9rr1eyyVtZsoKZTSskBapo1CdlOZiTZG4elMwn5vv1ro-oYaobQI0PLg1wv_0yyDAhDgjIMoIQaUt0-qw920gzCxIOIByFVCNKmG3qWDhoBaUBDcMkjOE_ZpY8eb6-ICiBABdxGRsP2NqQHnG_1EMa2_Xi8Bx0mhxSBhr3vD_z1bhFDC1BYkbgZQJ-_tPQjw0NE7AvrNfx-5zx6dHw_h6-nZl7dsN-S0hHrJd2xntVj790icVvZDmCJ_AAEBHRw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Hsp90+Affecting+Chromatin+Remodeling+Might+Explain+Transgenerational+Epigenetic+Inheritance+in+Drosophila&rft.jtitle=Current+genomics&rft.au=Ruden%2C+Douglas+M&rft.au=Lu%2C+Xiangyi&rft.date=2008-11-01&rft.pub=Bentham+Science+Publishers+Ltd&rft.issn=1389-2029&rft.eissn=1875-5488&rft.volume=9&rft.issue=7&rft.spage=500&rft.epage=508&rft_id=info:doi/10.2174%2F138920208786241207&rft_id=info%3Apmid%2F19506739&rft.externalDBID=PMC2691676 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1389-2029&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1389-2029&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1389-2029&client=summon |