Single-cell RNA-seq analysis reveals the progression of human osteoarthritis

• Published in: Annals of the rheumatic diseases Vol. 78; no. 1; pp. 100 - 110
• Main Authors: Ji, Quanbo, Zheng, Yuxuan, Zhang, Guoqiang, Hu, Yuqiong, Fan, Xiaoying, Hou, Yu, Wen, Lu, Li, Li, Xu, Yameng, Wang, Yan, Tang, Fuchou
• Format: Journal Article
• Language: English
• Published: England Elsevier Limited 01.01.2019; BMJ Publishing Group
• Series: Translational science
• Subjects: Arthritis; Arthroplasty (knee); Cartilage diseases; Cartilage, Articular - cytology; Cell cycle; Chondrocytes; Chondrocytes - metabolism; Chondrogenesis - genetics; Computational Biology; Computer applications; Degeneration; Disease Progression; Gene expression; Gene Expression Profiling; Homeostasis; Humans; Joint surgery; Kinases; Knee; Molecular modelling; Osteoarthritis; Osteoarthritis, Knee - genetics; Pathogenesis; Phenotype; Phenotypes; Progenitor cells; Ribonucleic acid; RNA; Sequence Analysis, RNA; Stem cells; Stem Cells - metabolism; Surgery; Taxonomy; Transcription; Transcriptome; Beijing China; China; knee osteoarthritis; osteoarthritis; chondrocytes

ObjectivesUnderstanding the molecular mechanisms underlying human cartilage degeneration and regeneration is helpful for improving therapeutic strategies for treating osteoarthritis (OA). Here, we report the molecular programmes and lineage progression patterns controlling human OA pathogenesis usin...